Prof. Hyun-Joon Ha
Hankuk University of Foreign Studies,
Korea
Email: hjha@hufs.ac.kr
Qualifications
1987 Ph.D., Brown University
1982 B.S., Seoul National
University
Publications (Selected)
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Ha, H.-J.; Lee, W. K.; Park, J. “Synthetic Ceramide Analogs for
Anticancer Agents” in Glycolipids: New Research, Nova Science Pub. New York,
2008. pp 145- 156.
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Kim, Y; Ha, H.-J.; Yun, S. Y.; Lee, W. K. “Preparation of Stable
Aziridinium Ions and Their Ring Openings” Chem. Commun. 2008, 4363-4365.
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Han, S.-M.; Ma, S.-h.; Ha, H.-J.; Lee, W. K. “Nucleophilic
substitution of (sulfonyloxymethyl)aziridines: asymmetric synthesis of
mexiletine”, Tetrahedron 2008, 64, 11110-11114.
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Jung, H. J.; Shim, J. S.; Park, J.; Ha, H.-J.; Kim, J.-H.; Kim,
J.-G.; Kim, N. D.; Yoon, J. H., Kwon, H. J. “Identification and validation of
calmodulin as a binding protein of an anti-proliferative small molecule
3,4-dihydroisoquinolinium salt”, PROTEOMICS - Clinical Applications 2009, 3,
423-432.
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Ha, H.-J.; Yoon, D.-H.; Kang, L.-S.; Hong, M. C.; Lee, W. K.
“Synthesis of D-erythro-Sphingosine from D-ribo-Phytosphingosine”, Bull. Kor.
Chem. Soc. 2009, 30, 535-536.
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Yun, S. Y.; Catak, S.; Lee, W. K.; D’hooghe, M.; De Kimpe, N.; Van
Speybroeck, V.; Waroquier, M.; Kim, Y.; Ha, H.-J. “Nucleophile-dependent
regioselective ring opening of 2-substituted N,N-dibenzylaziridinium ions:
bromide versus hydride”, Chem. Commun. 2009, 2508-2510.
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Kim, J. Y.; Park, H.; Lee, J. C.; Kim, K. M.; Lee, K. C.; Ha, H.
J.; Choi. T. H.; An, K. I.; Cheon, G. J. “A
simpleCu-64productionanditsapplication of Cu-64ATSM” Appli. Radiat Isot 2009,
67, 1190-1194.
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Park, J.-H.; Ha, H.-J.; Lee, W. K.; Généreux-Vincent, T.;
Kazlauskas, R. J. “Molecular basis for the stereoselective ammoniolysis of
alkyl aziridine-2-carboxylates catalyzed by Candida antarctica lipase B”
ChemBioChem. 2009, 10, 2213-2222.
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Lee, D-Y; Chun, J.-H.; Ha, H.-J.; Park, J.; Kim, B.-S.; Oh, H.-B.;
Rhie, G.-E. “Poly-c-D-glutamic acidand protective antigen conjugate vaccines
induce functional antibodies against the protective antigenand capsule of
Bacillus anthracis in guinea-pigs and rabbits” FEMS Immunology and Medical
Biology. (Federation of European Microbiological Societies) 2009, 57, 165-172.
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Lee, B. K.; Lee, W. K.; D-H. Yoon; Ha, H.-J. “Selective Reduction
of C-C Double Bonds of 2-Vinylaziridnes: Preparation of Enatiomerically Pure
2-Alkylaziridines” Bull. Kor. Chem. Soc. 2009, 30, 3123-3126.
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Cho, M.-H.; Ahn, H.-J.; Ha, H.-J.; Park, J.; Chun, J.-H.; Kim,
B.-S.; Oh, H.-B.; Rhie, G.-E. “Bacillus anthracis capsule Activates
Caspase-1/ICE and Induces Interleukin-1β release from Differentiated THP-1 and
Human Monocytederived Dendritic cells” Infect. Immun. 2010, 78, 387-392.
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Bharatham,N.; Bharatham,K.; Lee, Y.; Kim, S.; Lazar, P.; Baek, A.;
Park, C.; Eum, H.; Ha, H.-J.; Yun, S. Y.; Lee, W. K.; Kim, S.; Lee, K. W.
“Molecular Docking Study of Aminoacyl-tRNA Synthetases with Ligand Molecules
from Four Different Scaffolds”, Bull. Kor. Chem. Soc. 2010, 31, 606-610.
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Eum, H.; Lee, Y.; Kim, S.; Baek, A.; Son, M.; Lee, K. W.; Ko, S.
W.; Kim, S.; Sae Yun, S. Y.; Lee, W. K.; Ha, H.-J., “Synthesis of Substituted
Imidazolidin-2-ones as Aminoacyl-tRNA Synthase Inhibitors”, Bull. Kor. Chem.
Soc. 2010, 31, 611-614.
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Yoon, D.-H.; Ha, H.-J.; Kim, B. C.; Lee, W. K. “Conjugate addition
of amines to chiral 3-aziridin-2-yl-acrylates”, Tetrahedron Lett. 2010, 51,
2181-2183.
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Lee, J.-H.; Lee, S.; Park, M. Y.; Ha, H.-J.; Myung, H.
“Characterization of Thiobarbituric Acid Derivatives as Inhibitors of Hepatitis
C Virus NS5B Polymerase”, J. Microbiol. Biotechnol. 2010, 20. 510-512.
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Choi, H. G.; Kwon, J. H.; Kim, J. C.; Lee, W. K.; Eum, H.; Ha,
H.-J. “A Formal Synthesis of (─)-Swainsonine from a Chiral Aziridine”,
Tetrahedron Lett. 2010, 51, 3284-3285.
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Catak, S.; D’hooghe, M.; Verstraelen, T.; Hemelsoet, K.; Van
Nieuwenhove, A.; Ha, H.-J.; Waroquier, M.; Van Speybroeck, V.; De Kimpe, N.
“Opposite Regiospecific Ring Opening of 2-(cyanomethyl)aziridines by Hydrogen
Bromide and Benzyl Bromide- Experimental Proof and Theoretical
Rationalization.” , J. Org. Chem. 2010, 75, 4530-4541.
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D’hooghe, M.; Catak, S.; Stankovic, S.; Waroquier, M.; Y.; Kim;
H.-J. Ha; Van Speybroeck, V.; De Kimpe, N. “Systematic study of halide-induced
ring opening of 2-substituted aziridinium salts and theoretical rationalization
of the reaction pathways”, Eur. J. Org. Chem. 2010, 4920-4931.
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Choi, J. Y.; Kim, C. H., Kim, J. Y.; Ha, H.-J.; Ryu, Y. H. “An
Efficient Synthesis of trans-N-{2-[4-(2-methoxyphenyl)piperazinyl]ethyl}-N-(2-pyridyl)-N-(4-tosyloxymethylcyclohexane)carboxamide,
A precursor of [18F]-Mefway for Imaging 5-HT1A Receptor”, Bull. Kor. Chem. Soc.
2010, 31, 2371-2374.
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Kim, J. C.; Choi, H. G.; Kim, M. S.; H.-J. Ha; Lee, W. K. “An
efficient synthesis of enantiomerically pure aromatic-fused N-containing
heterocycles from common chiral aziridines”, Tetrahedron 2010, 66, 8108-8114.