Biography

Prof. Orazio Taglialatela-Scafati

Department of Pharmacy,

University of Naples Federico II, Italy


Email: scatagli@unina.it


Qualifications


1999 Post-doc. fellow, University of Naples, the Faculty of Pharmacy

1997 Ph.D., University of Naples Federico II, Pharmacologically Active Natural Products

1993 Italian Laurea in Pharmaceutical Chemistry and Technology


Publications (Selected)

  1. S. Gemma, E. Gabellieri, S. Sanna Coccone, F. Martì, O. Taglialatela-Scafati, E. Novellino, G. Campiani, S. Butini (2010). Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their C10-Desethyl Analogues. J. Org. Chem., 75, 2333-2340.
  2. O. Taglialatela-Scafati, A. Pagani, F. Scala, L. De Petrocellis, V. Di Marzo, G. Grassi, G. Appendino. (2010) Cannabimovone, a Cannabinoid with a Rearranged Terpenoid Skeleton from Hemp. Eur. J. Org. Chem., 2067-2072 .
  3. C. Fattorusso, M. Persico, B. Calcinai, C. Cerrano, S. Parapini, D. Taramelli, E. Novellino, A. Romano, F. Scala, E. Fattorusso, O. Taglialatela-Scafati. (2010). Manadoperoxides A-D from the Indonesian Sponge Plakortis cfr. simplex. Further Insights on the Structure-Activity Relationships of Simple 1,2-Dioxane Antimalarials. J. Nat. Prod., 73, 1138-1145.
  4. F. Scala, E. Fattorusso, M. Menna, O. Taglialatela-Scafati, M. Tierney, M. Kaiser, D. Tasdemir (2010). Bromopyrrole Alkaloids as Lead Compounds against Protozoan Parasites. Mar. Drugs, 8, 2162-2174.
  5. C. Fattorusso, M. Persico, N. Basilico, D. Taramelli, E. Fattorusso, F. Scala, O. Taglialatela-Scafati (2011). Antimalarials based on the dioxane scaffold of plakortin. A concise synthesis and SAR studies. Bioorg. Med. Chem., 19, 312-320.
  6. C. Avonto, O. Taglialatela-Scafati, F. Pollastro, A. Minassi, V. Di Marzo, L. De Petrocellis, G. Appendino (2011). An NMR Spectroscopic Method to Identify and Classify Thiol-Trapping Agents: Revival of Michael Acceptors for Dug Discovery? Angew. Chem. Int. Edit., 50, 467-471.
  7. G. Chianese, E. Fattorusso, O. O. Aiyelaagbe, P. Luciano, H.-C. Schroder, W. E. G. Muller, and O. Taglialatela-Scafati (2011). Spirocurcasone, a Diterpenoid with a Novel Carbon Skeleton from Jatropha curcas. Org. Lett., 13, 316-319.
  8. G. Appendino, G. Chianese, O. Taglialatela-Scafati (2011). Cannabinoids: Occurrence and Medicinal Chemistry. Curr. Med. Chem., 18, 1085-1099.
  9. A. Pagani, F. Scala, G. Chianese, G. Grassi, G. Appendino, O. Taglialatela-Scafati (2011). Cannabioxepane, a novel tetracyclic cannabinoid from hemp, Cannabis sativa L. Tetrahedron, 67, 3369-3373.
  10. S. Gemma, L. Colombo, G. Forloni, L. Savini, C. Fracasso, S. Caccia, M. Salmona, M. Brindisi, B. P. Joshi, P. Tripaldi, G. Giorgi, O. Taglialatela-Scafati, E. Novellino, I. Fiorini, G. Campiani, S. Butini  (2011). Pyrroloquinoxaline Hydrazones as Fluorescent Probes for Amyloid Fibrils. Org. Biomol. Chem., 9, 5137-5148.
  11. G. Chianese, E. Fattorusso, O. Taglialatela-Scafati, G. Bavestrello, B. Calcinai, H. A. Dien, A. Ligresti, V. Di Marzo (2011). Desulfohaplosamate, a new phosphate-containing steroid from Dasychalina sp., is a selective cannabinoid CB2 receptor ligand. Steroids, 76, 998-1002.
  12. F. Pollastro, O. Taglialatela-Scafati, M. Allarà, E. Munoz, V. Di Marzo, L. De Petrocellis, G. Appendino (2011). Bioactive Prenylogous Cannabinoid from Fiber Hemp (Cannabis sativa). J. Nat. Prod., 74, 2019-2022.
  13. M. Persico, A. Quintavalla, F. Rondinelli, C. Trombini, M. Lombardo, C. Fattorusso, V. Azzarito, D. Taramelli, S. Parapini, Y. Corbett, G. Chianese, E. Fattorusso, O. Taglialatela-Scafati (2011).A New Class of Antimalarial Dioxanes Obtained through a Simple Two-Step Synthetic Approach: Rational Design and Structure-Activity Relationship Studies. J. Med. Chem., 54, 8526-8540.
  14. R. Nassini, S. Materazzi, J. Vriens, J. Prenen, S. Benemei, G. De Siena, G.La Marca, E. Andrè, D. Preti, C. Avonto, L. Sadofsky, V. Di Marzo, L. De Petrocellis, G. Dussor, F. Porreca, O. Taglialatela-Scafati, G. Appendino, B. Nilius, P. Geppetti (2012). The “headache tree”, via umbellulone and TRPA1, activates the trigeminovascular system. Brain, 135, 376-390.
  15. M. Y. Putra, G. Bavestrello, C. Cerrano, B. Renga, C. D’Amore, S. Fiorucci, E. Fattorusso, O. Taglialatela-Scafati (2012).Polyhydroxylated sterols from the Indonesian soft coral Sinularia sp. and their effect on farnesoid X-activated receptor. Steroids, 77, 433-440.
  16. O. Taglialatela-Scafati, F. Pollastro, L. Cicione, G. Chianese, M. L. Bellido, E. Munoz, H. C. Ozen, Z. Toker, G. Appendino (2012). STAT-3 Inhibitory Bisabolanes from Carthamus glaucus. J. Nat. Prod., 75, 453-458.
  17. G. Chianese, E. Fattorusso, F. Scala, R. Teta, B. Calcinai, G. Bavestrello, H. A. Dien, M. Kaiser, D. Tasdemir, O. Taglialatela-Scafati (2012). Manadoperoxides, a New Class of Potent Antitrypanosomal Agents of Marine Origin. Org. Biomol. Chem., 10, 7197-7207.
  18. O. Taglialatela-Scafati, F. Pollastro, A. Minassi, G. Chianese, L. De Petrocellis, V. Di Marzo, G. Appendino (2012). Sesquiterpenoids from Common Ragweed (Ambrosia artemisiifolia L.), an Invasive Biological Polluter. Eur. J. Org. Chem., 5162-5170.
  19. G. Chianese, E. Fattorusso, M. Y. Putra, B. Calcinai, G. Bavestrello, A. Schiano Moriello, L. De Petrocellis, V. Di Marzo, O. Taglialatela-Scafati (2012). Leucettamols, Bifunctionalized Marine Sphingoids, Act as Modulators of TRPA1 and TRPM8 Channels. Mar. Drugs, 10, 2435-2447.
  20. O. Taglialatela-Scafati, F. Pollastro, G. Chianese, A. Minassi, S. Gibbons, W. Arunotayanun, B. Mabebie, M. Ballero, G. Appendino. (2013).    Antimicrobial phenolics and unusual glycerides from Helichrysum italicum subsp. microphyllum. J. Nat. Prod., 76, 346-353.
  21. G. Appendino, O. Taglialatela-Scafati (2013). Cannabinoids: Chemistry and Medicine. In “Natural Products” K. G. Ramawat and J.-M. Merillon Eds., Springer Publisher, Dordrecht (Netherlands), , pp. 3415-3435.
  22. A. Sinisi, B. Calcinai, C. Cerrano, H. A. Dien, A. Zampella, C. D’Amore, B. Renga, S. Fiorucci, O. Taglialatela-Scafati. (2013). Isoswinholide B and swinholide K, potently cytotoxic dimeric macrolides from Theonella swinhoei. Bioorg. Med. Chem., 21, 5332-5338.
  23. A. Sinisi, B. Calcinai, C. Cerrano, H. A. Dien, A. Zampella, C. D’Amore, B. Renga, S. Fiorucci, O. Taglialatela-Scafati. (2013). New Tridecapeptides of the theonellapeptolide family from the Indonesian sponge Theonella swinhoei. Beilstein J. Org. Chem., 9, 1643-1651.
  24. M. Persico, S. Parapini, G. Chianese, C. Fattorusso, M. Lombardo, L. Petrizza, A. Quintavalla, F. Rondinelli, N. Basilico, D. Taramelli, C. Trombini, E. Fattorusso, O. Taglialatela-Scafati. (2013). Furhter optimization of plakortin pharmacophore: Structurally simple 4-oxymethyl-1,2-dioxanes with promising antimalarial activity. Eur. J. Med. Chem., 70, 875-886.
  25. V. Sepe, C. D’Amore, R. Ummarino, B. Renga, M. V. D’Auria, E. Novellino, A. Sinisi, O. Taglialatela-Scafati, Y. Nakao, V. Limogelli, A. Zampella, S. Fiorucci (2014).  Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges. Eur. J. Med. Chem., 73, 126-134
  26. M. Lombardo, D. P. Sonawane, A. Quintavalla, C. Trombini, D. D. Dhavale, D. Taramelli, Y. Corbett, F. Rondinelli, C. Fattorusso, M. Persico, O. Taglialatela-Scafati. (2014). Optimized Synthesis and Antimalarial Activity of 1,2-Dioxane-4-carboxamides. Eur. J. Org. Chem., 1607-1614.
  27. Z.-F. Zhou, T. Kurtan, X.-H. Yang, A. Mandi, M.-Y. Geng, B.-P. Ye, O. Taglialatela-Scafati, Y.-W. Guo. (2014). Penibruguieramine A, a Novel Pyrrolizidine Alkaloid from the Endophytic Fungus Penicillium sp. GD6 Associated with Chinese Mangrove Bruguiera gymnorrhiza. Org. Lett., 16, 1390-1393
  28. G. Chianese, V. Sepe, V. Limongelli, B. Renga, C. D’Amore, A. Zampella, O. Taglialatela-Scafati, S. Fiorucci(2014). Incisterols, highly degraded marine sterols, are a new chemotype of PXR agonists. Steroids, 83, 80-85
  29. G. Appendino, A. Minassi, O. Taglialatela-Scafati (2014) Recreational drug discovery: natural products as lead structures for the synthesis of smart drugs. Nat. Prod. Rep., 31, 880-904
  30. A. Chicca, D. Caprioglio, A. Minassi, V. Petrucci, G. Appendino, O. Taglialatela-Scafati, J. Gertsch (2014). Functionalization of β-caryophyllene generates novel polypharmacology in the endocannabinoid system. ACS Chem. Biol., 9, 1499-1507
  31. Z.-F. Zhou, H.-L. Liu, W. Zhang, T. Kurtan, A. Mandi, A. Benyei, J. Li, O. Taglialatela-Scafati, Y.-W. Guo. (2014). Bioactive rearranged limonoids from the Chinese mangrove Xylocarpus granatum Koenig. Tetrahedron, 70, 6444-6449
  32. M. K. Rawal, Y. Shokoohinia, G. Chianese, B. Zolfaghari, G. Appendino, O. Taglialatela-Scafati, R. Prasad, A. Di Pietro (2014). Jatrophanes from Euphorbia squamosa as potent inhibitors of Candida albicans multidrug transporters. J. Nat. Prod., 77, 2700-2706
  33. G. Appendino, A. Minassi, J. A. Collado, F. Pollastro, G. Chianese, O. Taglialatela-Scafati, M. Ayyari, V. Garcia, E. Munoz. (2015). The Thia-Michael reactivity of zerumbone and related cross-conjugated dienones: disentangling stoichiometry, regiochemistry and addition mode with an NMR-spectroscopy based cysteamine assay. Eur. J. Org. Chem., 3721-3726


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