Prof.
Orazio Taglialatela-Scafati
Department of Pharmacy,
University of Naples Federico II, Italy
Email: scatagli@unina.it
Qualifications
1999 Post-doc.
fellow, University of Naples, the Faculty of Pharmacy
1997 Ph.D., University of Naples Federico II,
Pharmacologically Active Natural Products
1993 Italian Laurea in Pharmaceutical Chemistry
and Technology
Publications
(Selected)
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S.
Gemma, E. Gabellieri, S. Sanna Coccone, F. Martì, O. Taglialatela-Scafati, E.
Novellino, G. Campiani, S. Butini (2010). Synthesis of Dihydroplakortin, 6-epi-Dihydroplakortin, and Their
C10-Desethyl Analogues. J. Org. Chem., 75, 2333-2340.
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O.
Taglialatela-Scafati, A. Pagani, F. Scala, L. De Petrocellis, V. Di Marzo, G.
Grassi, G. Appendino. (2010)
Cannabimovone, a Cannabinoid with a Rearranged Terpenoid Skeleton from Hemp. Eur. J. Org. Chem., 2067-2072 .
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C.
Fattorusso, M. Persico, B. Calcinai, C. Cerrano, S. Parapini, D. Taramelli, E.
Novellino, A. Romano, F. Scala, E. Fattorusso, O. Taglialatela-Scafati. (2010). Manadoperoxides A-D from the
Indonesian Sponge Plakortis cfr. simplex. Further Insights on the
Structure-Activity Relationships of Simple 1,2-Dioxane Antimalarials. J.
Nat. Prod., 73, 1138-1145.
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F.
Scala, E. Fattorusso, M. Menna, O. Taglialatela-Scafati, M. Tierney, M. Kaiser,
D. Tasdemir (2010). Bromopyrrole Alkaloids as Lead Compounds
against Protozoan Parasites. Mar. Drugs, 8, 2162-2174.
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C. Fattorusso, M. Persico, N. Basilico, D.
Taramelli, E. Fattorusso, F. Scala, O. Taglialatela-Scafati (2011).
Antimalarials based on the dioxane scaffold of plakortin. A concise synthesis
and SAR studies. Bioorg. Med. Chem., 19, 312-320.
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C.
Avonto, O. Taglialatela-Scafati, F. Pollastro, A. Minassi, V. Di Marzo, L. De
Petrocellis, G. Appendino (2011). An
NMR Spectroscopic Method to Identify and Classify Thiol-Trapping Agents:
Revival of Michael Acceptors for Dug Discovery? Angew. Chem. Int. Edit., 50, 467-471.
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G.
Chianese, E. Fattorusso, O. O. Aiyelaagbe, P. Luciano, H.-C. Schroder, W. E. G.
Muller, and O. Taglialatela-Scafati (2011). Spirocurcasone, a Diterpenoid with
a Novel Carbon Skeleton from Jatropha
curcas. Org. Lett., 13, 316-319.
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G.
Appendino, G. Chianese, O. Taglialatela-Scafati (2011). Cannabinoids: Occurrence and Medicinal
Chemistry. Curr. Med. Chem., 18, 1085-1099.
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A.
Pagani, F. Scala, G. Chianese, G. Grassi, G. Appendino, O. Taglialatela-Scafati
(2011). Cannabioxepane, a novel tetracyclic cannabinoid from hemp, Cannabis sativa L. Tetrahedron, 67, 3369-3373.
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S.
Gemma, L. Colombo, G. Forloni, L. Savini, C. Fracasso, S. Caccia, M. Salmona,
M. Brindisi, B. P. Joshi, P. Tripaldi, G. Giorgi, O. Taglialatela-Scafati, E.
Novellino, I. Fiorini, G. Campiani, S. Butini
(2011). Pyrroloquinoxaline
Hydrazones as Fluorescent Probes for Amyloid Fibrils. Org. Biomol. Chem., 9, 5137-5148.
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G.
Chianese, E. Fattorusso, O. Taglialatela-Scafati, G. Bavestrello, B. Calcinai,
H. A. Dien, A. Ligresti, V. Di Marzo (2011). Desulfohaplosamate,
a new phosphate-containing steroid from Dasychalina sp., is a selective cannabinoid CB2 receptor ligand. Steroids, 76, 998-1002.
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F.
Pollastro, O. Taglialatela-Scafati, M. Allarà, E. Munoz, V. Di Marzo, L. De
Petrocellis, G. Appendino (2011). Bioactive
Prenylogous Cannabinoid from Fiber Hemp (Cannabis
sativa). J. Nat. Prod., 74, 2019-2022.
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M.
Persico, A. Quintavalla, F. Rondinelli, C. Trombini, M. Lombardo, C.
Fattorusso, V. Azzarito, D. Taramelli, S. Parapini, Y. Corbett, G. Chianese, E.
Fattorusso, O. Taglialatela-Scafati (2011).A New Class of Antimalarial Dioxanes
Obtained through a Simple Two-Step Synthetic Approach: Rational Design and
Structure-Activity Relationship Studies. J.
Med. Chem., 54, 8526-8540.
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R.
Nassini, S. Materazzi, J. Vriens, J. Prenen, S. Benemei, G. De Siena, G.La Marca, E. Andrè, D. Preti,
C. Avonto, L. Sadofsky, V. Di Marzo, L. De Petrocellis, G. Dussor, F. Porreca,
O. Taglialatela-Scafati, G. Appendino, B. Nilius, P. Geppetti (2012). The “headache tree”, via umbellulone and
TRPA1, activates the
trigeminovascular system. Brain, 135, 376-390.
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M.
Y. Putra, G. Bavestrello, C. Cerrano, B. Renga, C. D’Amore, S. Fiorucci, E.
Fattorusso, O. Taglialatela-Scafati (2012).Polyhydroxylated sterols from the
Indonesian soft coral Sinularia sp.
and their effect on farnesoid X-activated receptor. Steroids, 77, 433-440.
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O.
Taglialatela-Scafati, F. Pollastro, L. Cicione, G. Chianese, M. L. Bellido, E.
Munoz, H. C. Ozen, Z. Toker, G. Appendino (2012). STAT-3 Inhibitory Bisabolanes
from Carthamus glaucus. J. Nat. Prod., 75, 453-458.
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G.
Chianese, E. Fattorusso, F. Scala, R. Teta, B. Calcinai, G. Bavestrello, H. A.
Dien, M. Kaiser, D. Tasdemir, O. Taglialatela-Scafati (2012). Manadoperoxides,
a New Class of Potent Antitrypanosomal Agents of Marine Origin. Org.
Biomol. Chem., 10, 7197-7207.
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O.
Taglialatela-Scafati, F. Pollastro, A. Minassi, G. Chianese, L. De Petrocellis,
V. Di Marzo, G. Appendino (2012). Sesquiterpenoids from Common Ragweed (Ambrosia artemisiifolia L.), an Invasive
Biological Polluter. Eur. J. Org. Chem.,
5162-5170.
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G.
Chianese, E. Fattorusso, M. Y. Putra, B. Calcinai, G. Bavestrello, A. Schiano
Moriello, L. De Petrocellis, V. Di Marzo, O. Taglialatela-Scafati (2012). Leucettamols, Bifunctionalized Marine
Sphingoids, Act as Modulators of TRPA1 and TRPM8 Channels. Mar. Drugs, 10,
2435-2447.
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O.
Taglialatela-Scafati, F. Pollastro, G. Chianese, A. Minassi, S. Gibbons, W.
Arunotayanun, B. Mabebie, M. Ballero, G. Appendino. (2013). Antimicrobial phenolics and unusual
glycerides from Helichrysum italicum subsp. microphyllum. J. Nat. Prod., 76, 346-353.
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G.
Appendino, O. Taglialatela-Scafati (2013). Cannabinoids: Chemistry and Medicine. In “Natural Products” K. G. Ramawat and
J.-M. Merillon Eds., Springer Publisher, Dordrecht (Netherlands), , pp.
3415-3435.
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A.
Sinisi, B. Calcinai, C. Cerrano, H. A. Dien, A. Zampella, C. D’Amore, B. Renga,
S. Fiorucci, O. Taglialatela-Scafati. (2013). Isoswinholide B and swinholide K,
potently cytotoxic dimeric macrolides from Theonella
swinhoei. Bioorg. Med. Chem., 21,
5332-5338.
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A.
Sinisi, B. Calcinai, C. Cerrano, H. A. Dien, A. Zampella, C. D’Amore, B. Renga,
S. Fiorucci, O. Taglialatela-Scafati. (2013).
New Tridecapeptides of the theonellapeptolide family from the Indonesian sponge Theonella swinhoei. Beilstein J. Org. Chem., 9, 1643-1651.
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M.
Persico, S. Parapini, G. Chianese, C. Fattorusso, M. Lombardo, L. Petrizza, A.
Quintavalla, F. Rondinelli, N. Basilico, D. Taramelli, C. Trombini, E.
Fattorusso, O. Taglialatela-Scafati. (2013).
Furhter optimization of plakortin pharmacophore: Structurally simple
4-oxymethyl-1,2-dioxanes with promising antimalarial activity. Eur. J.
Med. Chem., 70, 875-886.
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V.
Sepe, C. D’Amore, R. Ummarino, B. Renga, M. V. D’Auria, E. Novellino, A.
Sinisi, O. Taglialatela-Scafati, Y. Nakao, V. Limogelli, A. Zampella, S.
Fiorucci (2014). Insights on
pregnane-X-receptor modulation. Natural
and semisynthetic steroids from Theonella marine sponges. Eur. J. Med. Chem., 73,
126-134
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M.
Lombardo, D. P. Sonawane, A. Quintavalla, C. Trombini, D. D. Dhavale, D.
Taramelli, Y. Corbett, F. Rondinelli, C. Fattorusso, M. Persico, O.
Taglialatela-Scafati. (2014). Optimized
Synthesis and Antimalarial Activity of 1,2-Dioxane-4-carboxamides. Eur. J.
Org. Chem., 1607-1614.
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Z.-F.
Zhou, T. Kurtan, X.-H. Yang, A. Mandi, M.-Y. Geng, B.-P. Ye, O.
Taglialatela-Scafati, Y.-W. Guo. (2014).
Penibruguieramine A, a Novel Pyrrolizidine Alkaloid from the Endophytic Fungus Penicillium sp. GD6 Associated with
Chinese Mangrove Bruguiera
gymnorrhiza. Org. Lett., 16,
1390-1393
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G.
Chianese, V. Sepe, V. Limongelli, B. Renga, C. D’Amore, A. Zampella, O.
Taglialatela-Scafati, S. Fiorucci(2014). Incisterols, highly degraded marine sterols, are a new
chemotype of PXR agonists. Steroids, 83, 80-85
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G. Appendino, A. Minassi, O.
Taglialatela-Scafati (2014) Recreational
drug discovery: natural products as lead structures for the synthesis of smart
drugs. Nat. Prod. Rep., 31,
880-904
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A.
Chicca, D. Caprioglio, A. Minassi, V. Petrucci, G. Appendino, O. Taglialatela-Scafati,
J. Gertsch (2014). Functionalization
of β-caryophyllene generates novel
polypharmacology in the endocannabinoid system. ACS Chem. Biol., 9, 1499-1507
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Z.-F.
Zhou, H.-L. Liu, W. Zhang, T. Kurtan, A. Mandi, A. Benyei, J. Li, O. Taglialatela-Scafati,
Y.-W. Guo. (2014). Bioactive rearranged limonoids from the Chinese
mangrove Xylocarpus granatum Koenig. Tetrahedron, 70, 6444-6449
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M.
K. Rawal, Y. Shokoohinia, G. Chianese, B. Zolfaghari, G. Appendino, O.
Taglialatela-Scafati, R. Prasad, A. Di Pietro (2014). Jatrophanes from Euphorbia
squamosa as potent inhibitors of Candida
albicans multidrug transporters. J.
Nat. Prod., 77, 2700-2706
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G.
Appendino, A. Minassi, J. A. Collado, F. Pollastro, G. Chianese, O.
Taglialatela-Scafati, M. Ayyari, V. Garcia, E. Munoz. (2015). The Thia-Michael reactivity of zerumbone
and related cross-conjugated dienones: disentangling stoichiometry,
regiochemistry and addition mode with an NMR-spectroscopy based cysteamine
assay. Eur. J. Org. Chem., 3721-3726