Prof. David Allen Hunt
The College of New Jersey, USA

Email: hunt@tcnj.edu

Qualifications

1979 Ph.D., Duke University, Organic Chemistry
1975 M.S., Marshall University, Organic Chemistry
1973 B.S., Marshall University, Chemistry

Publications (Selected)

1. Nayak, S.; Fiaschi, M.; King, D.; Tabakin, E. R.; Wood, L.; Hunt, D.A. “Development of small molecular proteasome inhibitors using a Caenorhabditis elegans screen” Int. Med. Chem. vol. 2014, Article ID 237286, 14 pages, 2014. doi:10.1155/2014/237286.
2. Cherney, E.; Macor, J.; Papanagapolous, C.; Hunt, D.A. “Tandem cyclization reactions of electron rich arylethylamino acid amides. An entry to the dihydroimidazoisoquinolin-3(2H)-one ring system,” Tetrahedron Lett. 2014, 55, 4837-4839.
3. Geherty, M.; Melnyk, J.; Chomsky, K.; Hunt, D.A. “Halogen-metal exchange reactions of bromoaryl-substituted β-lactams, Tetrahedron Lett. 2013, 54, 4934-4936.
4. Simpkins, C.; Hunt, D.A. “The Michael addition of 1,2-cyclohexanedione to -nitro- styrenes (I).  The synthesis of 3-aryl-5,6-dihydrobenzofuran-7(4H)-ones,” Tetrahedron Lett. 2013, 54, 3373-3375.
5. Weinstein, J.D.; Gonzalez, E.R.; Egleton, R.D.; Hunt, D.A. “The 10-patient screening protocol: a paradigm shift for evaluating pharmacotherapy for Alzheimer’s disease,” The Consultant Pharmacist 2013, 28, 443-454.
6. Bradley, L.M.; Nardone, M.J.; Hunt, D.A. “An expedient in situ preparation of symmetrical 1,4-dibenzylpiperazines from benzyl bromides and 2-bromoethylamine hydrobromide,” Tetrahedron Lett. 2010, 51, 5613-5614.
7. Bradley, L.M.; Collins, C.G.; Tabakin, E.R.; Hunt, D.A. “Expedient preparations of 4,6-Dihalo-3-arylisobenzofuran-1(3H)-ones from 3,5-dihalo-N-ethylbenzamides,” Org. Prep. Proced. Int. 2010, 42, 187-190.
8. Deifel, N.P.; Cherney, E.; Hunt, D.A.; Chan, B.C. “1-Methyl-2H-1,3-benzoxazine-2,4(1H)dione” Acta Cryst. 2010, E66, o665.
9. Hunt, D.A. “Solvent and electronic effects on kinetics of cyclization of thermolabile aryllithium reagents.  A comparison between 1-bromo-2-(2-bromoethyl)benzene and 4,5-dimethoxy-1-bromo-2-(2-bromoethyl)benzene,” Org. Commun. 2009, 2, 60-65.
10. Clarke A. J.; Hunt, D.A. “-Nitrostyrenes as electrophiles in Parham Cyclization chemistry.  Reaction with o-lithiobenzonitrile,” Tetrahedron Lett. 2009, 50, 2949-2951.
11. Hunt, D.A. "An improved method for the preparation of 2-(2-aminoaryl)-2-oxazolines from substituted isatoic anhydrides and 2-chloroethylamine hydrochloride," Org. Prep. Proced. Int. 2007, 39, 93-96.
12. Hunt, D.A. “Condensation of tricyclic pyrrolopyridine diones and an isoindoline dione with methylnitronate anion,” Heterocyclic Commun. 2006, 12, 403-406.
13. Demas, M.; Javadi, G.J.; Bradley, L.M.; Hunt, D.A. “Metalation of a 3,5-dichloro tertiary benzamide.  An unusual regioselectivity observation,” J. Org. Chem. 2000, 65, 7201-7202.
14. Henegar K.E.; Hunt, D.A. “Expedient preparations of 2-trifluoromethylindole and its N-methyl derivative,” Heterocycles 1996, 43, 1471-1475.
15. Hunt, D.A. “2-Arylpyrroles: a new class of insecticide.  Structure, activity, and mode of action,” Pest. Sci. 1996, 47, 201-202.
16. Barnes, K.D.; Hu, Y.; Hunt, D.A. “Electrophilic fluorination of a highly functionalized pyrrole,” Syn. Commun. 1994, 24, 1749-1755.
17. Treacy, M.; Miller, T.; Black, B.; Gard, I.; Hunt, D.A.; Hollingworth, R.M. “Uncoupling activity and pesticidal properties of pyrroles,” Biochem. Soc. Trans. 1994, 22, 244-247.
18. Hunt, D.A. “Michael addition of organolithium compounds.  A review,” Org. Prep. Proced. Int. 1989, 21, 705-749.
19. Hunt, D.A. “An efficient preparation of 1,2-dihydrocyclobuta-[a]-naphthalene,” Org. Prep. Proced. Int. 1989, 21, 360-363.
20. Hunt, D.A.; Quante, J.M.; Tyson, R.L.; Dasher, L.W. “The preparation and utilization of corticosteroidal -allylpalladium complexes. A novel entry to 6-,-carboxymethylcortisol,” J. Org. Chem. 1984, 49, 5262-5264.
21. Bradsher, C.K.; Hunt, D.A. “A novel synthesis of benzo[1,2:4,5] dicyclobutane via a dual Parham Cyclialkylation,” J. Org. Chem. 1981, 46, 4608-4610.
22. Bradsher C.K.; Hunt, D.A. “Schiff bases as external and internal electrophiles in reactions of functionalized aryllithium reagents. A new route to isoindoline derivatives and 1,2,3,4-tetrahydroisoquinolines,” J. Org. Chem. 1981, 46, 327-330.
23. Bradsher, C.K.; Hunt, D.A. “A new route to the acridizinium ion,” J. Org. Chem. 1980, 45, 4248-4250.
24. Reames, D.C.; Hunt, D.A.; Bradsher, C.K. “A one-pot synthesis of some dibenzosuberones via the Parham Cycliacylation reaction,” Synthesis 1980, 454-456.
25. Hunt, D.A. “A study of the reaction of functionalized aryllithium reagents with internal and external electrophiles.  A pathway to the synthesis of heterocyclic and carbocyclic systems,” Diss. Abstr. Int. B. 1980, 40, 3741.
26. Bradsher C.K.; Hunt, D.A. “An efficient synthesis of 4,5-dimethoxybenzocyclobutane via the Parham Cyclialkylation reaction,” Org. Prep. Proced. Int. 1978, 10, 267-272.
27. Parham, W.E.; Bradsher, C.K.; Hunt, D.A. “Reaction of aryllithium reagents with nitriles.  Synthesis of 1-substituted-3,4-dihydroisoquinolines,” J. Org. Chem. 1978, 43, 1606-1607.
28. Douglass, J.E.; Hunt, D.A. “Synthesis of quinolizinones by the condensation of ylidenemalononitriles with quinoline-1-oxide,” J. Org. Chem. 1977, 42, 3974-3976.