Dr. Horst Christian Weber
Boston University School of Medicine, USA

Email: christian.weber@bmc.org

Qualifications

2007-present Associate Chief and Clinical Director, Gastroenterology VA Boston Health Care System, USA

1998-present Staff Physician, VA Boston Health Care System, USA

1997-present Staff Physician, Boston Medical Center, USA

Publications (Selected)

1. Fathia Gibril, James C.Reynolds, John L.Doppman, Clara C.Chen, David J.Venzon, Basel Termanini, H.Christian Weber, Charmaine A.Stewart, and Robert T.Jensen: Somatostatin Receptor Scintigraphy: A prospective study of its sensitivity compared to other imaging modalities in detecting primary and metastatic gastrinomas. Ann.Int.Med. 1996; 125 (1): 26-34
2. B.Termanini, F.Gibril, C.A.Stewart, H.C.Weber, R.T.Jensen: A prospective study of the effectiveness of low dose omeprazole as initial therapy in Zollinger-Ellison syndrome. Alim.Pharm.Ther. 1996; 10: 61-71
3. Luis J.Garcia, Tapas K.Pradhan, H.Christian Weber, Terry W.Moody, Robert T.Jensen: The gastrin-releasing peptide receptor is differentially coupled to adenylate cyclase and phospholipase C in different tissues. BBA 1997; 1356: 343-354
4. H.C.Weber, D.J.Venzon, R.T.Jensen, D.C.Metz: Studies on the Interaction Between Zollinger-Ellison Syndrome, Helicobacter pylori Gastritis and Proton Pump Inhibitor Therapy. Gastroenterology 1997; 112: 84-91
5. C.A.Stewart, B.Termanini, V.Sutliff, V.Corleto, H.C.Weber, F.Gibril, and R.T.Jensen: Management of Zollinger-Ellison Syndrome in Pregnancy. Am.J.Obstet.Gynecol.1997; 176 (Number 1, Part 1): 224-233
6. S.A.Mantey, H.C.Weber, E.Sainz, M.Akeson, R.R.Ryan, T.K.Pradhan, E.R.Spindel, J.F.Battey, D.C.Coy, and R.T.Jensen: Discovery of a high affinity radioligand for the human orphan receptor, BRS-3, which demonstrates it has a unique pharmacology compared to other mammalian bombesin receptors. J.Biol.Chem. 1997; 272: 26062-26071
7. Debbie J.Marsh, Patricia L.M.Dahia, Valerie Coulon, Zimu Zheng, Francoise Dorion-Bonnet, Katherine M.Call, Randall Little, Albert Y.Lin, Rosalind A.Eeles, Alisa M.Goldstein, Shirley V. Hodgson, Anne-Louise Richardson, Bruce G.Robinson, H.Christian Weber, Michel Longy and Charis Eng: Allelic imbalance, including deletion of PTEN/MMAC1, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation. Genes, Chromosomes and Cancer 1998; 21: 61-69
8. H.C.Weber, L.L.Hampton, R.T.Jensen, J.F.Battey: Structure and Chromosomal Localization of the Mouse Bombesin Receptor Subtype 3 Gene. Gene 1998; 211(1): 125-131
9. Tapas K.Pradhan, Tatsuro Katsuno, John E.Taylor, Sun H.Kim, Samuel A.Mantey, Patrick Donohue, H.Christian Weber, Eduardo Sainz, James F.Battey, David H.Coy, Robert T.Jensen: Identification of a unique ligand which has high affinity for all four of bombesin receptor subtypes. Eur.J.Pharmacol. 1998; 343(2-3): 275-287
10. R.Ryan, H.C.Weber, W.Hou, E.Sainz, S.Mantey, J.Battey, D.H.Coy, R.Jensen: Ability of Various Bombesin Receptor Agonists and Antagonists to Alter Intracellular Signaling of the Human Orphan Receptor BRS-3. J.Biol.Chem. 1998; 273: 13613-1324
11. Lori L.Hampton, Ellen E.Ladenheim, Mark Akeson, James M.Way, H.Christian Weber, Vincent Sutliff, Robert T.Jensen, Lara J.Wine, Heinz Arnheiter, and James F.Battey: Loss of Bombesin-Induced Feeding Suppression in Gastrin-Releasing Peptide Receptor Deficient Mice. Proc.Natl.Acad.Sci.1998; 95: 3188-3192
12. R.Ryan, H.C.Weber, S.Mantey, W.Hou, M.E.Hilgruber, T.K.Pradhan, D.H.Coy, and R.Jensen:
13. Pharmacology and intracellular signaling mechanisms of the native human orphan receptor BRS-3 in lung cancer cells. J.Pharm.Exp.Ther. 1998; 287: 366-380
14. V.D.Corleto, H.C.Weber, R.T.Jensen,: Expression of Somatostatin Receptor Subtypes on Guinea Pig Gastric and Colonic Smooth Muscle Cells. Am. J. Physiol. 1999; 277: G235-G244
15. R.Ryan, T.Katsuno, S.Mantey, T.K.Pradhan, H.C.Weber, D.H.Coy, J.F.Battey, and R.Jensen: Comparative Pharmacology of the Nonpeptide Neuromedin B Receptor Antagonist PD 168368. J.Pharm.Exp.Ther. 1999; 290: 1202-1211
16. H.C.Weber, R.T.Jensen, and J.F.Battey: Molecular organization of the mouse gastrin-releasing peptide receptor gene and its promoter. Gene 2000; 244: 137- 149
17. D. Xiao, J. Wang, L.L. Hampton, and H.C.Weber: The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter. Gene 2001; 264(1): 95‑103
18. H.C. Weber, J. Walters, J. Leyton, M. Casibang, S. Purdom, R.T. Jensen, D.H. Coy, C Ellis, G. Clark, and T.W. Moody: A bombesin receptor subtype‑3 peptide increases nuclear oncogene expression in a MEK‑1 dependent manner in human lung cancer cells. Eur.J.Pharmacol. 2001; 412: 13‑20
19. Harris, P.R., Weber, H.C., Wilcox, C.M., Jensen, R.T., and Smith, P.D.: Cytokine Profile in Gastric Mucosa in Helicobacter pylori Infection and Zollinger-Ellison Syndrome. Am J Gastroenterol 2002; 97: 312-318