Dr. Christian Joukhadar
Harvard Medical School, USA
Email: christian.joukhadar@jp-medical-research.com
Qualifications
Associate Professor, Harvard Medical School, USA
Publications (Selected)
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Kielstein JT, Eugbers C, Bode-Boeger SM,
Martens-Lobenhoffer J, Haller H,Joukhadar C, Traunmüller F, Knitsch W, Hafer C,
Burkhardt O. Dosing ofdaptomycin in intensive care unit patients with acute
kidney injuryundergoing extended dialysis--a pharmacokinetic study. Nephrol
DialTransplant. 2009 Dec 22. [Epub ahead of print] [impact; 3.568]
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Joukhadar C, Pillai S, Wennersten C,
Moellering RC Jr, Eliopoulos GM. Lackof Bactericidal Antagonism or Synergism In
Vitro Between Oxacillin andVancomycin Against Methicillin-Susceptible Strains
of StaphylococcusAureus. Antimicrob Agents Chemother. 2009 Nov 23. [Epub ahead
of print][impact; 4.716]
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Popovic M, Steinort D, Pillai S, Joukhadar
C. Fosfomycin: an old, newfriend? Eur J Clin Microbiol Infect Dis. 2009 Nov 14.
[Epub ahead of print][impact; 2.866]
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Kovar FM, Marsik CL, Jilma B, Mannhalter
C, Joukhadar C, Wagner OF,Endler G. The inflammatory response is influenced by
FXIII VAL 34 LEUpolymorphism in a human LPS model. Wien Klin Wochenschr.
2009Aug;121(15-16):515-519. [impact; 0.857]
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Schintler MV, Traunmüller F, Metzler J,
Kreuzwirt G, Spendel S, Mauric O,Popovic M, Scharnagl E, Joukhadar C. High
fosfomycin concentrations inbone and peripheral soft tissue in diabetic
patients presenting with bacterialfoot infection. J Antimicrob Chemother. 2009
Sep;64(3):574-8. Epub 2009Jul 3. [impact; 4.328]
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Khadzhynov D, Joukhadar C, Peters H.
Plasma and peritoneal dialysatelevels during daptomycin therapy for
peritonitis. Am J Kidney Dis. 2009May;53(5):911-2. [impact; 4.822]
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Traunmüller F, Fille M, Thallinger C,
Joukhadar C. Multiple-dosepharmacokinetics of telithromycin in peripheral soft
tissues. Int J AntimicrobAgents. 2009 Jul;34(1):72-5. Epub 2009 Apr 19.
[impact; 3.067]
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Joukhadar C, Thallinger C, P?ppl W, Kovar
F, Konz KH, Joukhadar SM,Traunmüller F. Concentrations of voriconazole in
healthy and inflamed lungin rats. Antimicrob Agents Chemother. 2009
Jun;53(6):2684-6. Epub 2009Mar 30. [impact; 4.716]
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Traunmüller F, Thallinger C, Hausdorfer J,
Lambers C, Tzaneva S,Kampitsch T, Endler G, Joukhadar C. Tigecycline has no
effect on cytokinerelease in an ex vivo endotoxin model of human whole blood.
Int JAntimicrob Agents. 2009 Jun;33(6):583-6. Epub 2009 Jan 25 [impact;3.067]
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Thallinger C, Skorjanec S, Soleiman A,
Tzaneva S, Griss J, Rous W, PoepplW, Weinlich G, Karimian-Teherani D, Joukhadar
C. Orally administeredrapamycin, dacarbazine or both for treatment of human
melanomaevaluated in severe combined immunodeficiency mice.
Pharmacology.2008;82(3):233-8. Epub 2008 Sep 23. [impact; 1.894]
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Burklein D, Heyn J, Kirchhoff C, Ozimek A,
Traunmuller F, Joukhadar C,Rothenburger M, Mutschler W, Heindl B. Analysis of
plasma and peritonealfluid concentrations of daptomycin in a patient with
Enterococcus faeciumperitonitis. Int J Antimicrob Agents. 2008
Oct;32(4):369-71. [impact;3.067]
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Ehrlich HJ, Muller M, Oh HM, Tambyah PA,
Joukhadar C, Montomoli E,Fisher D, Berezuk G, Fritsch S, L?w-Baselli A, Vartian
N, Bobrovsky R,Pavlova BG, P?llabauer EM, Kistner O, Barrett PN; Baxter H5N1
PandemicInfluenza Vaccine Clinical Study Team. A clinical trial of a
whole-virus H5N1vaccine derived from cell culture. N Engl J Med. 2008 Jun
12;358(24):2573-84. [impact; 50.017]
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Sauermann R, Mayer-Helm BX, Petsch M,
Popovic M, Thallinger C,Joukhadar C. Is experimental endotoxaemia in humans
suitable forsimulating antibiotic pharmacokinetics in sepsis and septic shock?
A pilotstudy using the model compound fosfomycin. Int J Antimicrob Agents.
2008Mar;31(3):291-2. [impact; 3.067]
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Marsik C, Kazemi-Shirazi L, Schickbauer T,
Winkler S, Joukhadar C,Wagner OF, Endler G. C-reactive protein and all-cause
mortality in a largehospital-based cohort. Clin Chem. 2008 Feb;54(2):343-9.
[impact; 5.579]
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Stolle LB, Plock N, Joukhadar C, Arpi M,
Emmertsen KJ, Buerger C,Riegels-Nielsen P, Kloft C. Pharmacokinetics of
linezolid in bone tissueinvestigated by in vivo microdialysis. Scand J Infect
Dis. 2008;40(1):24-9.[impact; 1.678]
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Kaehler S, Marsik C, Heinisch B,
Thallinger C, Sauermann R, Kazemi-ShiraziL, Wagner O, Joukhadar C. S-ibuprofen
effectively inhibits thromboxaneB2 levels and platelet function in an
experimental model oflipopolysaccharide-stimulated and non-stimulated whole
blood.Pharmacology. 2008;81(2):181-6. [impact; 1,894]
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Burkhardt O, Joukhadar C, Traunmüller F,
Hadem J, Welte T, Kielstein JT, Elimination of daptomycin in a patient
with acute renal failure undergoingextended daily dialysis. J Antimicrob
Chemother. 2008 Jan;61(1):224-5.[impact; 4.328]
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Thallinger C, Buerger C, Plock N, Kljucar
S, Wuenscher S, Sauermann R,Kloft C, Joukhadar C. Effect of severity of sepsis
on tissue concentrationsof linezolid. J Antimicrob Chemother. 2008
Jan;61(1):173-6. Epub 2007 Nov13. [impact; 4.328]
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Sauermann R, Rothenburger M, Graninger W,
Joukhadar C. Daptomycin: areview 4 years after first approval. Pharmacology.
2008;81(2):79-91. Epub2007 Oct 16. [impact; 1.894]
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Thallinger C, Rothenburger M, Marsik C,
Wuenscher S, Popovic M, Endler G,Wagner O, Joukhadar C. Daptomycin does not
exert immunomodulatoryeffects in an experimental endotoxin model of human whole
blood.Pharmacology. 2008;81(1):57-62. Epub 2007 Sep 11. [impact; 1.894]
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Abrahim A, Luurtsema G, Bauer M, Karch R,
Lubberink M, Pataraia E,Joukhadar C, Kletter K, Lammertsma AA, Baumgartner C,
Müller M,Langer O. Peripheral metabolism of (R)-[(11)C]verapamil in
epilepsypatients. Eur J Nucl Med Mol Imaging. 2008 Jan;35(1):116-23. Epub
2007Sep 11. [impact; 4.532]
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Sacher J, Mossaheb N, Spindelegger C,
Klein N, Geiss-Granadia T,Sauermann R, Lackner E, Joukhadar C, Muller M, Kasper
S. Effects ofOlanzapine and Ziprasidone on Glucose Tolerance in Healthy
Volunteers
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Neuropsychopharmacology. 2007 Aug 22;
[Epub ahead of print] [impact;6.157]
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Plock N, Buerger C, Joukhadar C, Kljucar
S, Kloft C. Does Linezolid inhibitits own metabolism? - Population
pharmacokinetics as a tool to explain theobserved nonlinearity in both healthy
volunteers and septic patients. DrugMetab Dispos. 2007 Oct;35(10):1816-23. Epub
2007 Jul 16. [impact;3.907]
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Traunmuller F, Zeitlinger M, Zeleny P,
Muller M, Joukhadar C, Pharmacokinetics of single- and
multiple-dose oral clarithromycin in softtissues determined by microdialysis.
Antimicrob Agents Chemother. 2007Sep;51(9):3185-9. Epub 2007 Jul 2. [impact;
4.309]
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Thallinger C, Werzowa J, Poeppl W, Kovar
FM, Pratscher B, Valent P,Quehenberger P, Joukhadar C. Comparison of a
Treatment StrategyCombining CCI-779 Plus DTIC Versus DTIC Monotreatment in
HumanMelanoma in SCID Mice. J Invest Dermatol. 2007 May 17; [Epub ahead
ofprint] [impact; 4.829]
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Langer O, Bauer M, Hammers A, Karch R,
Pataraia E, Koepp MJ, Abrahim A,Luurtsema G, Brunner M, Sunder-Plassmann R,
Zimprich F, Joukhadar C,Gentzsch S,Dudczak R, Kletter K, Muller M, Baumgartner
C, Pharmacoresistance in Epilepsy: A Pilot
PET Study with the P-GlycoproteinSubstrate R-[C]verapamil. Epilepsia. 2007 May
1; [Epub ahead of print][impact; 3.569]
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Chaurasia CS, Muller M, Bashaw ED,
Benfeldt E, Bolinder J, Bullock R,Bungay PM, Delange EC, Derendorf H, Elmquist
WF, Hammarlund-UdenaesM, Joukhadar C, Kellogg DL Jr, Lunte CE, Nordstrom CH,
Rollema H,Sawchuk RJ, Cheung BW, Shah VP, Stahle L, Ungerstedt U, Welty DF,
YeoH. AAPS-FDA Workshop White Paper: Microdialysis Principles, Applicationand
Regulatory Perspectives. J Clin Pharmacol. 2007 May;47(5):589-603.[impact;
2.993]
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Last Updated: August, 2012.
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