Prof. Ben A. Bahr
Biotechnology Research and Training Center
University of North Carolina – Pembroke, USA
William C. Friday Chair and Professor of Molecular Biology and
Biochemistry
Email: Bahr@uncp.edu
Qualifications
1989 Ph.D., University of California, USA, Chemistry
1984 B.A., University of
California, USA, Molecular Biology and Biochemistry
Publications (selected)
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Sabatini DM, Barrow RK, Blackshaw S, Burnett PE, Lai MM, Field ME, Bahr
BA, Kirsch J, Betz H, and Snyder SH (1999) Interaction of RAFT1 with gephyrin
required for rapamycin‑sensitive signaling. Science, 284: 1161‑1164.
(PMID: 10325225).
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Bendiske J, Caba E, Brown QB, and Bahr BA (2002) Intracellular deposition,
microtubule destabilization, and transport failure: An “early” pathogenic
cascade leading to synaptic decline. J Neuropathol Exp Neurol, 61: 640-650.
(PMID: 12125743).
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Bendiske J and Bahr BA (2003) Lysosomal activation is a compensatory
response against protein accumulation and associated synaptopathogenesis – an
approach for slowing Alzheimer disease? J Neuropathol Exp Neurol, 62: 451-463.
(PMID: 12769185).
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Caba E and Bahr BA (2004) Biphasic activation of NF-kB in the excitotoxic
hippocampus. Acta Neuropathologica, 108: 173-182. (PMID: 15138780).
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Karanian DA, Brown QB, Makriyannis A, and Bahr BA (2005) Blocking
cannabinoid activation of FAK and ERK1/2 compromises synaptic integrity in
hippocampus. Eur J Pharmacol, 508: 47-56.
(PMID: 15680253).
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Karanian DA, Brown QB, Makriyannis A, Kosten TA, and Bahr BA (2005) Dual
modulation of endocannabinoid transport and fatty acid amide hydrolase protects
against excitotoxicity. J Neuroscience, 25: 7813-7820.
(PMID: 16120783).
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Karanian DA, Baude A, Brown QB, Parsons C, and Bahr BA (2006)
3-Nitropropionic acid toxicity in hippocampus: protection through
N-methyl-D-aspartate receptor antagonism. Hippocampus, 16: 834-42.
(PMID: 16897723).
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Butler D, Bendiske J, Michaelis ML, Karanian DA, and Bahr BA (2007)
Microtubule-stabilizing agent prevents protein accumulation-induced loss of
synaptic markers. Eur J Pharmacol, 562: 20-27. (PMID:
17336290).
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Chicoine LM and Bahr BA (2007) Excitotoxic protection by polyanionic
polysaccharide: Evidence of a cell survival pathway involving AMPA
receptor-MAPK interactions. J Neuroscience Res, 85: 294-302.
(PMID: 17131415).
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Kosten TA, Karanian DA, Yeh J, Haile CN, Kim JJ, Kehoe P, and Bahr BA
(2007) Memory impairments and hippocampal modifications in adult rats with
neonatal isolation stress experience. Neurobiol Learning Memory 88:167-176.
(PMID: 17543553).
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Karanian DA, Karim SL, Wood JT, Williams JS, Lin S, Makriyannis A, and
Bahr BA (2007) Endocannabinoid enhancement protects against kainic acid-induced
seizures and associated brain damage. J Pharmacol Exp Ther, 322: 1059-1066.
(PMID: 17545313).
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Ryzhikov S and Bahr BA (2008) Gephyrin alterations due to protein
accumulation stress are reduced by the lysosomal modulator
Z-Phe-Ala-diazomethylketone. J Mol Neuroscience, 34: 131-139.
(PMID: 18204977).
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Pin SS and Bahr BA (2008) Protein kinase C is a common component of CGRP
receptor desensitization induced by distinct agonists. Eur J Pharmacol, 587: 8-15.
(PMID: 18420188).
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Naidoo V, Nikas SP, Karanian DA, Hwang J, Zhao J, Wood JT, Alapafuja SO,
Vadivel SK, Butler D, Makriyannis A, and Bahr BA (2011) A new generation fatty
acid amide hydrolase inhibitor protects against kainate-induced excitotoxicity. J
Mol Neuroscience, 43: 493-502. (PMID: 21069475).
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Wisniewski ML, Hwang J, and Bahr BA (2011) Submicromolar Aβ42 reduces
hippocampal glutamate receptors and presynaptic markers in an
aggregation-dependent manner. Biochim Biophys Acta, 1812: 1664-74.
(PMID: 21978994).
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Butler D, Hwang J, Estick C, Nishiyama A, Kumar SS, Baveghems C,
Young-Oxendine HB, Wisniewski ML, Charalambides A, and Bahr BA (2011)
Protective effects of positive lysosomal modulation in Alzheimer’s disease
transgenic mouse models. PLoS One, 6: e20501 (pp: 1-16).
(PMID: 21695208).
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Naidoo V, Karanian DA, Vadivel SK, Locklear JR, Wood JT, Nasr M, Quizon
PM, Graves EE, Shukla V, Makriyannis A, and Bahr BA (2012) Equipotent
inhibition of fatty acid amide hydrolase and monoacylglycerol lipase – dual
targets of the endocannabinoid system to protect against seizure pathology. Neurotherapeutics, 9: 801-13.
(PMID: 22270809).
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Viswanathan K, Hoover DJ, Hwang J, Wisniewski ML, Ikonne US, Bahr BA, and
Wright DL (2012) Nonpeptidic lysosomal modulators derived from
Z-Phe-Ala-diazomethylketone for treating protein accumulation diseases. ACS
Med Chem Lett, 3: 920-924. (PMID: 24900408).
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Melo CV, Okumoto S, Gomes JR, Baptista MS, Bahr BA, Frommer WB & Duarte
CB (2013) Spatiotemporal resolution of BDNF neuroprotection against glutamate
excitotoxicity in cultured hippocampal neurons. Neuroscience, 237: 66-86.
(PMID: 23384605).
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Filipovic R, Kumar SS, Bahr BA & Loturco J (2014) Slice cultures for
studying migration of neuronal progenitor cells derived from human embryonic
stem cells. Curr Protoc Stem Cell Biol, 29: 1H.7.1-14.
(PMID: 24838914).
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Bahr BA (2014) A single pathway targets several health challenges of the
elderly. Rejuvenation Res, 17: 382-384. (PMID: 24953230).
Profile Details
http://www.uncp.edu/academics/research/biotech-center/research