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Biography

Prof. Markus J. Seibel

The University of Sydney, Australia


Email: mjs@anzac.edu.au


Qualifications


1997 Ph.D., University of Heidelberg, Germany

1984 M.D., University of Mainz, Germany


Publications (selected)

  1. Ooi LL, Zhou H, Kalak R, Zheng Y, Conigrave AD, Seibel MJ, Dunstan CR. Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis. Cancer Res 70: 1835-44, 2010.
  2. Weber AJ, Li G, Kalak R, Street J, Buttgereit F, Dunstan CR, Seibel MJ, Zhou H. Osteoblast-targeted disruption of glucocorticoid signaling does not delay intramembranous bone healing. Steroids. 2010 [Epub ahead of print].
  3. Birzniece V, Meinhardt U, Gibney J, Johannsson G, Baxter RC, Seibel MJ, Ho KY  Modulatory Effect of Raloxifene and Estrogen on the Metabolic Action of Growth Hormone in Hypopituitary Women. J Clin Endocrinol Metab 2010 (in press)
  4. Wong T, Girgis C, Ngu MC, Chen RY, Emmett L, Archer KA, Seibel MJ. Hypophosphatemic Osteomalacia after Low-Dose Adefovir Dipivoxil Therapy for Hepatitis B. J Clin Endocrinol Metab 95(2):479–480, 2010.
  5. Zhou H, Mak W, Kalak R, Street J, Fong-Yee C, Zheng Y, Dunstan C, Seibel MJ. Glucocorticoid Dependent Wnt Signaling by Mature Osteoblasts Is a Key Regulator of Cranial Skeletal Development in Mice. Development 136; 427-436, 2009.
  6. Blair JM; Modzelewski JR; Perryman LA; Russell P, Seibel MJ; Dunstan CR. Prolonged anti-resorptive treatment of lytic prostate cancer xenografts in mouse bone results in tumour necrosis. J Cancer Molec 2009 (in press)
  7. Buttgereit F, Zhou H, Kalak R, Gaber T, Spies CM, Huscher D, Straub RH, Modzelewski J, Dunstan CR, Seibel MJ. Transgenic disruption of glucocorticoid signaling in mature osteoblasts and osteocytes attenuates K/BxN mouse serum-induced arthritis in vivo. Arthritis Rheum 60: 1998-2007, 2009.
  8. Kalak R, Zhou H, Dunstan C, Day R, Modzelewski J, Li G, Seibel MJ. Endogenous glucocorticoid signaling in osteoblasts is necessary to maintain normal bone structure in mice. Bone 45: 61-7, 2009
  9. Chen JS, Sambrook PN, Simpson JM, Cameron ID, Cumming RG, Seibel MJ, Lord SR, March LM Risk factors for hip fracture among institutionalised older people. Age & Ageing 38: 429-34, 2009
  10. Cumming RG, Handelsman D, Seibel MJ, Creasey H, Sambrook P, Waite L, Naganathan V, Le Couteur D, Litchfield M. Cohort Profile: the Concord Health and Ageing in Men Project. Intl J Epidemiol. 38: 374-8, 2009.
  11. Cameron ID, Chen JS, March LM, Simpson JM, Cumming RG, Seibel MJ, Sambrook PN. Hip Fracture Causes Excess Mortality Due to Cardiovascular and Infectious Disease in Institutionalized Older People: A Prospective Five-Year Study. J Bone Miner Res. 2009 Oct 19. [Epub ahead of print]
  12. Mak W, Shao X, Dunstan CR, Seibel MJ, Zhou H Biphasic Glucocorticoid-Dependent Regulation of Wnt Expression and Its Inhibitors in Mature Osteoblastic Cells. Calcif Tissue Int 85:538-45, 2009.
  13. Lee P, Greenfield JR, Seibel MJ, Eisman JA, Center JR. Adequacy of vitamin D replacement in severe deficiency is dependent on body mass index. Am J Med. 122: 1056-60, 2009.
  14. Chen JS, Sambrook PN, March L, Cameron ID, Cumming RG, Simpson JM, Seibel MJ.  Hypovita-minosis D and parathyroid hormone response in the elderly: effects on bone turnover and mortality. Clin Endocrinol (Oxf) 68: 290-8, 2008.
  15. Neudert M, Fischer C, Krempien B, Seibel MJ, Bauss F   A histological score for the evaluation of osteolytic tumour burden in experimental breast cancer metastases. Onkologie 31: 521-527, 2008
  16. Nelson AE, Meinhardt U, Hansen, Walker I, Stone G, Howe CJ, Leung C, Seibel MJ, Baxter RC, Handelsman DJ, Kazlauskas R, Ho KK. Pharmacodynamics of GH abuse biomarkers and the influence of gender and testosterone: a randomized double-blind placebo-controlled study in young recreational athletes. J Clin Endocrin Metabolism 93: 2213-22, 2008.
  17. Sànchez L, Wilson N, Kok C, Sambrook PN, Cumming R, Cameron ID, Chen JS, Simpson J, Mason RS, Seibel MJ, March LM. Trends in calcium and vitamin D usage among older people in nursing care facilities in Australia: still falling short of the guidelines. Int J Rheum Dis 2008; 11: 430–434
  18. Zheng Y, Zhou H, Fong C, Modzelewski JR, Seibel MJ, Dunstan CR. Bone resorption increases tumour growth in osteosclerotic breast cancer metastasis. Clin Exp Metastasis 25: 559-67, 2008.
  19. Nguyen TV, Nelson AE, Howe CJ, Seibel MJ, Baxter RC, Handelsman DJ, Kazlauskas R, Ho KK Within-subject variability and analytic imprecision of IGF axis and collagen markers in healthy individuals. Clin Chemistry 54: 1268-76, 2008
  20. Zhou H, Mak W, Zheng Y, Dunstan C, Seibel MJ  Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through WNT signaling. J Biol Chem 283: 1936-45, 2008
  21. Lee P, Seibel MJ More on atypical fractures of the femoral diaphysis. NEJM 359:3, 316-318, 2008
  22. Buttgereit F, Zhou H, Seibel MJ. Arthritis and endogenous glucocorticoids: the emerging role of the 11 beta HSD-enzymes. Editorial. Ann Rheum Dis 67 (9): 1201-1203, 2008 .
  23. Meier C, Nguyen TV, Handelsman DJ, Schindler C, Center JR, Eisman JA, Seibel MJ   Serum Testosterone is Associated with Incident Fracture Risk in Older Men: The Dubbo Osteoporosis Epidemiology Study. Arch Int Medicine 168: 47-54, 2008.
  24. Chen JS, Simpson JM, March LM, Cameron ID, Cumming RG, Lord SR, Seibel MJ, Sambrook PN. Risk Factors for Fracture Following a Fall Among Older People in Residential Care Facilities in Australia. J Am Geriatr Soc. 2008 Sep 22. [Epub ahead of print]
  25. Blyth FM, Rochat S, Cumming R, Handelsman D, LeCouteur D, Naganathan V, Sambrook PN, Seibel MJ. Pain, Frailty and Comorbidity in Older Men: the CHAMP study. Pain 2008 Oct 1. [Epub a.o.p.]
  26. Cumming RG, Handelsman D, Seibel MJ, Creasey H, Sambrook P, Waite L, Naganathan V, Couteur DL, Litchfield M. Cohort profile: The Concord Health and Ageing in Men Project (CHAMP). Int J Epidemiol. 2008 May 14. [Epub ahead of print].
  27. Nguyen TV, Nelson AE, Howe CJ, Seibel MJ, Baxter RC, Handelsman DJ, Kazlauskas R, Ho KK Within-subject variability and analytic imprecision of IGF axis and collagen markers in healthy individuals. Clin Chemistry Jun 20, 2008 [Epub ahead of print] PMID: 18567697
  28. Chen JS, Simpson JM, March LM, Cameron ID, Cumming RG, Lord RS, Seibel MJ, Sambrook PN.  Fracture risk assessment in frail older people using clinical risk factors. Age and Ageing 2008