Prof. Hermona Soreq
The Hebrew University of Jerusalem, Israel
Email: soreq@cc.huji.ac.il
Qualifications
2005 The Hebrew University
1976 The Weizmann Institute of Science
Publications (Selected)
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Shenhar-Tsarfaty, S., Bruck, T., Bennett, E.R., Bravman, T., Ben- Assayag, E., Waiskopf, N., Rogowski, O., Bornstein, N., Berliner S. and Soreq, .H. (2010). Butyrylcholinesterase interactions with amylin may protect pancreatic cells in metabolic syndrome. J. Cell. Mol. Med., 15, 1747-56.
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Ben Assayag,, E., Shenhar-Tsarfaty, S.,, Ofek, K., Soreq, L., Bova, I., Shopin, L., Berg, R., Berliner, S., Shapira, I., Bornstein, N. M. and Soreq, H. (2010). Serum cholinesterase activities distinguish between stroke patients and controls and predict 12 month mortality. Mol.Med, 16:278-286.
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Ben Assayag,, E., Shenhar-Tsarfaty, S.,, Ofek, K., Soreq, L., Bova, I., Shopin, L., Berg, R., Berliner, S., Shapira, I., Bornstein, N. M. and Soreq, H. (2010). Serum cholinesterase activities distinguish between stroke patients and controls and predict 12 month mortality. Mol.Med, 16:278-286.
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Shaked, I., Meerson, A., Wolf, Y., Avni, R., Greenberg, D. S., Gilboa-Geffen, A. and Soreq, H. (2009). MicroRNA-132 Potentiates Cholinergic Anti-Inflammatory Signaling by Targeting Acetylcholinesterase Immunity, 31; 965-973 cover.
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Podoly, E., Shalev, D., Shenhar-Tsarfaty, S., Bennett, E., Ben-Assayag, E., Wilgus, H., Livnah, O. and Soreq, H.. (2009) The butyrylcholinesterase K variant confers structurally-derived risks for Alzheimer’s pathology {diamondsuit}.. J Biol Chem. 284, 17170-17179. (June 2009 Article of the Week).
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Berson, A., Knobloch, M., Diamant, S., Sharoni, M., Schuppli, D., Geyer, B., Ravid, R., Mor, T., Nitsch, R. and Soreq, H. (2008). Changes in Readthrough Acetylcholinesterase Expression Modulate Amyloid-Beta Pathology. Brain, 131, 109-119.
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Gilboa-Gefen, A., Lacoste P., Soreq, L. Truffault, F., Soreq, H. and Berrih-Aknin, S. (2007). The thymic theme of acetylcholinesterase splice variants in myasthenia gravis. Blood, 109, 4383-4391.
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Grisaru, D., Pick, M., Perry, C., Sklan, E.H., Almog, R., Goldberg, I., Naparstek, E., Lessing, J.B., Soreq H. and Deutsch, V, (2006). Hydrolytic and non-enzymatic functions of acetylcholinesterase co-modulate hematopoietic stress responses. J. Immunol, 176, 27-35.
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Meshorer, E. and Soreq, H. (2006) Virtues and woes of AChE alternative splicing in stress-related neuropathologies. Trends in Neurosci., 29, 216-224.
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Meshorer, E., Bryk, B., Toiber, D., Cohen, J., Dori, A. and Soreq H. (2005). SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA. Mol. Psych., 10, 985-997, Lilly Award.
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Sklan, E.H, Lowenthal, A., Korner, M., Ritov, Y., Rankinen, T., Bouchard, C., Leon, A.S., Rao, D.C., Wilmore, J.H., Skinner, J.S. and Soreq, H. (2004). Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study. PNAS, 101, 5512-5517.
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Nijholt, I., Farchi, N., Kye, M.-J., Sklan, E., Shoham, S., Verbeurre, B., Owen D., Hochner, B., Spiess, J., Soreq, H. and Blank., T. (2004). Stress-induced alternative splicing modulation of acetylcholinesterase results in enhanced fear memory and long-term-potentiation. Mol. Psych., 9, 174-183.
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Meshorer, E., Erb, C. Gazit, R., Pavlovsky, L., Kaufer, D., Glick, D., Friedman, A., Ben-Arie, N. and Soreq, H. (2002). Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity. Science, 295, 508-512.
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Cohen, O., Erb, C., Ginzberg, D., Pollak, Y., Shohami, S., Seidman, S., Soreq, H., and Yirmiya, R. (2002). Overexpression of “readthrough” acetylcholinesterase is associated with antisense suppressible behavioral impairments. Mol. Psych. 7, 874–885.
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Soreq, H. and Seidman, S. (2001). Acetylcholinesterase – new roles for an old actor. Nature Neuroscience Reviews 2, 294-302.
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Kaufer, D., Friedman, A., Seidman, S. and Soreq, H. (1998). Acute stress facilitates long-lasting changes in cholinergic gene expression. Nature 393, 373-377. Accompanied by: News & Views: The stress of Gulf War Syndrome. Sapolsky, R.M. Nature, 393:308-309.
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Friedman, A., Kaufer-Nachum, D., Shemer, J., Hendler, I., Soreq, H. and Tur-Kaspa, I. (1996). Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response. Nature Medicine 2:1382-1385.
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Loewenstein-Lichtenstein, Y., Schwarz, M., Glick, D., Norgaard-Pederson, B., Zakut, H. and Soreq, H. (1995) Genetic predisposition to adverse consequences of anti-cholinesterases in "atypical" BCHE carriers. Nature Medicine, 1, 1082-1085.