Biography

Prof. Hermona Soreq

  The Hebrew University of Jerusalem, Israel


  Email: soreq@cc.huji.ac.il


Qualifications
2005 The Hebrew University

  1976 The Weizmann Institute of Science


Publications (Selected)
  1. Shenhar-Tsarfaty, S., Bruck, T., Bennett, E.R., Bravman, T., Ben- Assayag, E., Waiskopf, N., Rogowski, O., Bornstein, N., Berliner S. and Soreq, .H. (2010). Butyrylcholinesterase interactions with amylin may protect pancreatic cells in metabolic syndrome. J. Cell. Mol. Med., 15, 1747-56.
  2. Ben Assayag,, E., Shenhar-Tsarfaty, S.,, Ofek, K., Soreq, L., Bova, I., Shopin, L., Berg, R., Berliner, S., Shapira, I., Bornstein, N. M. and Soreq, H. (2010). Serum cholinesterase activities distinguish between stroke patients and controls and predict 12 month mortality. Mol.Med, 16:278-286.
  3. Ben Assayag,, E., Shenhar-Tsarfaty, S.,, Ofek, K., Soreq, L., Bova, I., Shopin, L., Berg, R., Berliner, S., Shapira, I., Bornstein, N. M. and Soreq, H. (2010). Serum cholinesterase activities distinguish between stroke patients and controls and predict 12 month mortality. Mol.Med, 16:278-286.
  4. Shaked, I., Meerson, A., Wolf, Y., Avni, R., Greenberg, D. S., Gilboa-Geffen, A. and Soreq, H. (2009). MicroRNA-132 Potentiates Cholinergic Anti-Inflammatory Signaling by Targeting Acetylcholinesterase Immunity, 31; 965-973 cover.
  5. Podoly, E., Shalev, D., Shenhar-Tsarfaty, S., Bennett, E., Ben-Assayag, E., Wilgus, H., Livnah, O. and Soreq, H.. (2009) The butyrylcholinesterase K variant confers structurally-derived risks for Alzheimer’s pathology {diamondsuit}.. J Biol Chem. 284, 17170-17179. (June 2009 Article of the Week).
  6. Berson, A., Knobloch, M., Diamant, S., Sharoni, M., Schuppli, D., Geyer, B., Ravid, R., Mor, T., Nitsch, R. and Soreq, H. (2008). Changes in Readthrough Acetylcholinesterase Expression Modulate Amyloid-Beta Pathology. Brain, 131, 109-119.
  7. Gilboa-Gefen, A., Lacoste P., Soreq, L. Truffault, F., Soreq, H. and Berrih-Aknin, S. (2007). The thymic theme of acetylcholinesterase splice variants in myasthenia gravis. Blood, 109, 4383-4391.
  8. Grisaru, D., Pick, M., Perry, C., Sklan, E.H., Almog, R., Goldberg, I., Naparstek, E., Lessing, J.B., Soreq H. and Deutsch, V, (2006). Hydrolytic and non-enzymatic functions of acetylcholinesterase co-modulate hematopoietic stress responses. J. Immunol, 176, 27-35.
  9. Meshorer, E. and Soreq, H. (2006) Virtues and woes of AChE alternative splicing in stress-related neuropathologies. Trends in Neurosci., 29, 216-224.
  10. Meshorer, E., Bryk, B., Toiber, D., Cohen, J., Dori, A. and Soreq H. (2005). SC35 promotes sustainable stress-induced alternative splicing of neuronal acetylcholinesterase mRNA. Mol. Psych., 10, 985-997, Lilly Award.
  11. Sklan, E.H, Lowenthal, A., Korner, M., Ritov, Y., Rankinen, T., Bouchard, C., Leon, A.S., Rao, D.C., Wilmore, J.H., Skinner, J.S. and Soreq, H. (2004). Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study. PNAS, 101, 5512-5517.
  12. Nijholt, I., Farchi, N., Kye, M.-J., Sklan, E., Shoham, S., Verbeurre, B., Owen D., Hochner, B., Spiess, J., Soreq, H. and Blank., T. (2004). Stress-induced alternative splicing modulation of acetylcholinesterase results in enhanced fear memory and long-term-potentiation. Mol. Psych., 9, 174-183.
  13. Meshorer, E., Erb, C. Gazit, R., Pavlovsky, L., Kaufer, D., Glick, D., Friedman, A., Ben-Arie, N. and Soreq, H. (2002). Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity. Science, 295, 508-512.
  14. Cohen, O., Erb, C., Ginzberg, D., Pollak, Y., Shohami, S., Seidman, S., Soreq, H., and Yirmiya, R. (2002). Overexpression of “readthrough” acetylcholinesterase is associated with antisense suppressible behavioral impairments. Mol. Psych. 7, 874–885.
  15. Soreq, H. and Seidman, S. (2001). Acetylcholinesterase – new roles for an old actor. Nature Neuroscience Reviews 2, 294-302.
  16. Kaufer, D., Friedman, A., Seidman, S. and Soreq, H. (1998). Acute stress facilitates long-lasting changes in cholinergic gene expression. Nature 393, 373-377. Accompanied by: News & Views: The stress of Gulf War Syndrome. Sapolsky, R.M. Nature, 393:308-309.
  17. Friedman, A., Kaufer-Nachum, D., Shemer, J., Hendler, I., Soreq, H. and Tur-Kaspa, I. (1996). Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response. Nature Medicine 2:1382-1385.
  18. Loewenstein-Lichtenstein, Y., Schwarz, M., Glick, D., Norgaard-Pederson, B., Zakut, H. and Soreq, H. (1995) Genetic predisposition to adverse consequences of anti-cholinesterases in "atypical" BCHE carriers. Nature Medicine, 1, 1082-1085.
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