Dr. Zufeng
Guo
Department
of Pharmacology and Molecular Sciences
Johns
Hopkins University School of Medicine, USA
Research
Associate
Email: zguo11@jhmi.edu, guozufeng@hotmail.com
Qualifications
2010-present Ph.D., Johns Hopkins University School of
Medicine, Baltimore, USA
2003-2010 Ph.D., Hong Kong University of Science and
Technology, Hong Kong, China
2000-2003 M.S., Fuzhou University, Fuzhou, China
1996-2000 B.S., Fuzhou University, Fuzhou, China
Publications (Selected)
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Guo,
Z.F.; Hong, S.; Wang, J.X.; Rehan, S.; Liu, W.K.; Peng, H.J.; Das, M.; Li, W.;
Bhat, S.; Peiffer, B.; Ullman, B.R.; Tse, C.M.; Tarmakova, Z.; Schiene-Fischer,
C.; Fischer, G.; Coe, I.; Paavilainen, V.O.; Sun, Z.L.; Liu, J.O.
Rapamycin-inspired macrocycles with new target specificity. Nat. Chem.
accepted.
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Kosowicz,
J.G.; Lee, J.; Peiffer, B.; Guo, Z.F.; Chen, J.M.; Liao, G.L.; Hayward, S.D.;
Liu, J.O.; Ambinder, R.F. (2017) Drug modulators of B cell signaling pathways
and Epstein-Barr virus lytic activation. J. Virol. 91, e00747-17.
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McClary,
B.; Zinshteyn, B.; Meyer, M.; Jouanneau, M.; Pellegrino, S.; Yusupova, G.;
Schuller, A.; Reyes, J.C.; Lu, J.Y.; Guo, Z.F.; Ayinde, S.; Luo, C.; Dang,
Y.J.; Romo, D.; Yusupov, M.; Green, R.; Liu, J.O. (2017) Inhibition of
Eukaryotic Translation by the Antitumor Natural Product Agelastatin A. Cell
Chem.Biol. 24, 605-613.
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Haynes,
R.K.; Cheu, K.-W.; Chan, H.-W.; Wong, H.-N.; Li, K.-Y.; Tang, M.M.-K.; Chen,
M.-J.; Guo, Z.-F.; Guo, Z.-H.; Sinniah, K.; Witte, A.B.; Coghi, P.; Monti, D.
(2012) Interactions between Artemisinins and other Antimalarial Drugs in
Relation to the Cofactor Model - A Unifying Proposal for Drug Action.
ChemMedChem 7, 2204-2226.
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Haynes,
R.K.; Cheu, K.-W.; Li, K.-Y.; Tang, M.M.-K.; Wong, H.-N.; Chen, M.-J.; Guo,
Z.-F.; Guo, Z.-H.; Coghi, P.; Monti, D. (2011) A Partial Convergence in Action
of Methylene Blue and Artemisinins: Antagonism with Chloroquine, a Reversal
with Verapamil, and an Insight into the Antimalarial Activity of Chloroquine.
ChemMedChem 6, 1603-1615.
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Haynes,
R.K; Cheu, K.-W.; Tang, M.M.-K.; Chen, M.-J.; Guo, Z.-F.; Guo, Z.-H.; Coghi,
P.; Monti, D. (2011) Reactions of Antimalarial Peroxides with Each of
Leucomethylene Blue and Dihydroflavins: Flavin Reductase and the Cofactor Model
Exemplified. ChemMedChem 6, 279-291.
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Chen,
M.; Jiang, M.; Sun, Y.; Guo, Z.-F.; Guo, Z. (2011) Stabilization of the Second
Oxyanion Intermediate by 1,4-Dihydroxy-2-naphthoyl- Coenzyme A Synthase of the
Menaquinone Pathway: Spectroscopic Evidence of the Involvement of a Conserved
Aspartic Acid. Biochemistry 50, 5893-5904.
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Jiang,
M.; Chen, M.J.; Guo, Z.-F.; Guo, Z. (2010) A Bicarbonate Cofactor Modulates
1,4-Dihydroxy-2-naphthoyl-Coenzyme A Synthase in Menaquinone Biosynthesis of
Escherichia coli. J. Biol. Chem. 285, 30159-30169.
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Chen,
X.L.; Guo, Z.-F.; Lai, P.M.; Sze, K.H.; Guo, Z. (2010) Identification of a
nonaketide product for the iterative polyketide synthase in biosynthesis of the
nine-membered enediyne C-1027. Angew. Chem. Int. Ed. 49, 7926-7928.
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Guo,
Z.-F.; Jiang, M.; Zheng, S.; Guo, Z. (2010) Structural change of the
enterobactin synthetase in crowded solution and its relation to
crowding-enhanced product specificity in nonribosomal enterobactin
biosynthesis. Bioorg. Med. Chem. Lett. 20, 3855-3858.
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Guo,
Z.-F.; Sun, Y.; Zheng, S.; Guo, Z. (2009) Preferential hydrolysis of aberrant
intermediates by the type II thioesterase in Escherichia coli nonribosomal
enterobactin synthesis: substrate specificities and mutagenic studies on the
active site residues. Biochemistry 48, 1712–1722.
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Gao,
Y.; Kuang, Y.; Guo, Z.-F.; Guo, Z.; Krauss I.J.; Xu, B. (2009)
Enzyme-instructed molecular self-assembly confers nanofibers and a
supramolecular hydrogel of taxol derivative. J. Am. Chem. Soc. 131, 13576-13577.
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Guo,
Z.-F.; Jiang, M.; Zheng, S.; Guo, Z. (2008) Suppression of linear side products
by macromolecular crowding in nonribosomal enterobactin biosynthesis. Org.
Lett. 10, 649–652. (C&EN Sci. & Tech. concentrate highlight:
https://pubs.acs.org/cen/ news/86/i06/8606news5.html).
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Jiang,
M.; Chen, X.; Guo, Z.-F.; Cao, Y.; Chen, M.; Guo, Z. (2008) Identification and
characterization of (1R, 6R)-2-succinyl-6-hydroxy-2,
4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of
Escherichia coli. Biochemistry 47, 3426–3434.
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Yang,
Z. M.; Xu, K. M.; Guo, Z. -F.; Guo, Z.; Xu, B. (2007) Intracellular enzymatic
formation of nanofibers results in hydrogelation and regulated cell death. Adv.
Mater. 19, 3152–3156.
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Jiang,
M.; Cao, Y.; Guo, Z.-F.; Chen, M.; Chen, X.; Guo. Z. (2007) Menaquinone
biosynthesis in Escherichia coli: Identification of 2-succinyl-5-enolpyruvyl-
6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) as a novel intermediate and
re-evaluation of MenD activity. Biochemistry 46, 10979–10989.
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Yang,
Z.; Liang, G.; Guo, Z.F.; Guo, Z.; Xu, B. (2007) Intracellular hydrogelation of
small molecules inhibits bacterial growth. Angew. Chem. Int. Ed. 46, 8216–8219.
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Tong,
H.; Hong, Y. N.; Dong, Y. Q.; Haussler, M.; Lam, J. W. Y.; Li, Z.; Guo, Z.F.;
Guo, Z.; Tang, B. Z. (2006) Fluorescent "light-up" bioprobes based on
tetraphenylethylene derivatives with aggregation-induced emission
characteristics. Chem. Commun. 35, 3705–3707.
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Zhong,
X.; Guo, Z.F.; Yang, H.; Peng, L.; Xie, Y.; Wong, T.-Y.; Lai, S.-T.; Guo, Z.
(2006) Amino terminus of the SARS coronavirus protein 3a elicited strong,
potentially protective humoral responses in infected patients. J. Gen. Virol.
87, 369–374.
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Zhong,
X.; Yang, H.; Guo, Z.-F.; Sin, W.-Y. F.; Chen, W.; Xu, J.; Fu L.; Wu, J.; Mak,
C.-K.G.; Cheng, C.-S.S.; Yang, Y.; Cao S.; Wong, T.-Y.; Lai, S.-T.; Xie, Y.;
Guo, Z. (2005) B cell responses in patients who have recovered from severe
acute respiratory syndrome target a dominant site in the S2 domain of the
surface spike glycoprotein. J. Virol. 79, 3401–3408.
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Ouyang,
X.; Xie, Z.; Guo, Z.F.; Lin, X.; Guo, L. (2004) Study of direct
fluorophotometric and flow-injection fluorophotometric methods based on the
inhibitory effect for the determination of trace formaldehyde. Spectrosc.
Spect. Anal. 24, 1395-1399.