Prof. Wan Lee
Dongguk
University, South Korea
Email:
wanlee21@yahoo.com
Qualification
1998 Ph.D.,
Seoul National University, Biochemistry and Biophysics
1988 M.Sc.,
Seoul National University, Physiology
1986 D.V.M.,
Seoul National University, Veterinary Medicine
Publications(Selected)
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Won-Mo Yang,
Hyo-Jin Jeong, Seung-Yoon Park, Wan Lee (2014) Saturated fatty acid-induced
miR-195 impairs insulin signaling and glycogen metabolism in HepG2 cells. FEBS Lett.
588(21): 3939-3946.
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Won-Mo Yang,
Wan Lee (2014) CTRP5 ameliorates palmitate-induced apoptosis and insulin
resistance through activation of AMPK and fatty acid oxidation. Biochem Biophys
Res Commun. 452(3): 715-721.
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Won-Mo Yang,
Hyo-Jin Jeong, Seung-Yoon Park, Wan Lee (2014) Induction of miR-29a by
saturated fatty acids impairs insulin signaling and glucose uptake through
translational repression of IRS-1 in myocytes. FEBS letters 588(13): 2170-2176.
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Marco
Tomasetti, Linda Nocchi, Sara Staffolani, Nicola Manzella, Monica Amati, Jacob
Goodwin, Maria Nguyen, Katarina Kluckova, Martina Bajzikova, Margaryta Sobol,
Pavel Hozak, Sandra Lettlova, Jaroslav Truksa, Wan Lee, Lanfeng Dong, Lory
Santarelli, Jiri Neuzil (2014) MicroRNA-126 Suppresses Mesothelioma Malignancy
by Targeting IRS1 and Interfering with Mitochondrial Function. Antioxidants
& Redox Signaling 01/2014.
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Hyo-Jin Jeong,
Seung-Yoon Park, Won-Mo Yang, Wan Lee (2013) The induction of miR-96 by
mitochondrial dysfunction causes impaired glycogen synthesis through
translational repression of IRS-1 in cultured hepatoma cells. Biochemical and
Biophysical Research Communications 434(3): 503-508.
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Seung-Yoon
Park, Hyo-Jin Jeong, Won-Mo Yang, Wan Lee (2013) Implications of microRNAs in
the pathogenesis of diabetes. Archives of Pharmacal Research 36(2): 154-166.
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Eun-Ju Park,
Mi-Jin Kim, Wan Lee, Seung-Yoon Park (2012) Ets-2 is involved in
transcriptional regulation of C1qTNF-related protein 5 in muscle cells.
Molecular Biology Reports 39(10): 9445-9451.
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Mi-Jin Kim,
Eun-Ju Park, Wan Lee, Jung-Eun Kim, Seung-Yoon Park (2012) Regulation of the
transcriptional activation of CTRP3 in chondrocytes by c-Jun. Molecular and
Cellular Biochemistry 368(1-2): 111-117.
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Mi-Jin Kim,
Wan Lee, Eun-Ju Park, Seung-Yoon Park (2012) Depletion of mitochondrial DNA
stabilizes C1qTNF-related protein 6 mRNA in muscle cells. Journal of Korean
Medical Science 27(5): 465-470.
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Hyun Su Ryu,
Seung-Yoon Park, Duan Ma, Jin Zhang, Wan Lee (2011) The induction of microRNA
targeting IRS-1 is involved in the development of insulin resistance under
conditions of mitochondrial dysfunction in hepatocytes. PLoS ONE
6(3): e17343.
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Hyun-Ho Hwang,
Pyong-Gon Moon, Jeong-Eun Lee, Jung-Guk Kim, Wan Lee, Sung-Ho Ryu, Moon-Chang
Baek (2011) Identification of the target proteins of rosiglitazone in 3T3-L1
adipocytes through proteomic analysis of cytosolic and secreted proteins.
Molecules and Cells 31(3): 239-246.
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Mi-Jin Kim,
Wan Lee, Eun-Ju Park, Seung-Yoon Park (2010) Role of hepatocyte nuclear
factor-4alpha in transcriptional regulation of C1qTNF-related protein 5 in the
liver. FEBS letters 584(14): 3080-3084.
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Wan Lee,
Mi-Jin Kim, Eun-Ju Park, Young-Jin Choi, Seung-Yoon Park (2010) C1qTNF-related
protein-6 mediates fatty acid oxidation via the activation of the AMP-activated
protein kinase. FEBS letters 584(5): 968-972.
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Wan Lee, Hyo
Im Choi, Mi Jin Kim, Seung Yoon Park (2008) Depletion of mitochondrial DNA
up-regulates the expression of MDR1 gene via an increase in mRNA stability.
Experimental and Molecular Medicine 40(1): 109-117.
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Seung Y Park,
Yoo H Choi, Wan Lee (2008) Dangnyohwan improves glucose utilization and reduces
insulin resistance by increasing the adipocyte-specific GLUT4 expression in
Otsuka Long-Evans Tokushima Fatty rats. Journal of Ethnopharmacology
115(3): 473-482.
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Young Ok Choi,
Jong-Ha Park, Young Sook Song, Wan Lee, Yoshinori Moriyama, Han Choe, Chae Hun
Leem, Yeon Jin Jang (2008) Involvement of vesicular H+-ATPase in
insulin-stimulated glucose transport in 3T3-F442A adipocytes. Endocrine Journal
54(5): 733-743.
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Seung Y Park,
and Wan Lee (2007) The depletion of cellular mitochondrial DNA causes insulin
resistance through the alteration of insulin receptor substrate-1 in rat
myocytes. Diabetes Research and Clinical Practice 77 Suppl 1: S165-S171.
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Seung Y. Park,
Sanghyun Lee, Kyong S. Park, Hong K.Lee and Wan Lee(2006) Proteomic Analysis of
Cellular Change Involved in Mitochondria-to-Nucleus Communication in L6
GLUT4myc Myocytes. Proteomics6, 1210-1222.
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Young O. Choi,
Hee J. Ryu, Hye R. Kim, Young S. Song, Cheon H. Kim, Wan Lee, Han Choe, Chae H.
Leem, and Yeon J. Jang (2006) Implication of phosphorylation of the myosin II
regulatory light chain in insulin-stimulated GLUT4 translocation in 3T3-F442A
adipocytes. Exp. Mol. Med. 38: 180-189.
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Seung Y. Park,
Guem H. Choi, Hyo I. Choi, Jiwon Ryu, Chan Y. Jung, and Wan Lee(2005) Depletion of
mitochondrial DNA causesimpaired glucose utilization andinsulin resistance in L6
GLUT4myc myocytes. J. Biol. Chem. 280(11), 9855-9864.