Prof. Wan Lee

Dongguk University, South Korea

Email: wanlee21@yahoo.com

Qualification

1998 Ph.D., Seoul National University, Biochemistry and Biophysics

1988 M.Sc., Seoul National University, Physiology

1986 D.V.M., Seoul National University, Veterinary Medicine

Publications(Selected)

1. Won-Mo Yang, Hyo-Jin Jeong, Seung-Yoon Park, Wan Lee (2014) Saturated fatty acid-induced miR-195 impairs insulin signaling and glycogen metabolism in HepG2 cells. FEBS Lett. 588(21): 3939-3946.
2. Won-Mo Yang, Wan Lee (2014) CTRP5 ameliorates palmitate-induced apoptosis and insulin resistance through activation of AMPK and fatty acid oxidation. Biochem Biophys Res Commun. 452(3): 715-721.
3. Won-Mo Yang, Hyo-Jin Jeong, Seung-Yoon Park, Wan Lee (2014) Induction of miR-29a by saturated fatty acids impairs insulin signaling and glucose uptake through translational repression of IRS-1 in myocytes. FEBS letters 588(13): 2170-2176.
4. Marco Tomasetti, Linda Nocchi, Sara Staffolani, Nicola Manzella, Monica Amati, Jacob Goodwin, Maria Nguyen, Katarina Kluckova, Martina Bajzikova, Margaryta Sobol, Pavel Hozak, Sandra Lettlova, Jaroslav Truksa, Wan Lee, Lanfeng Dong, Lory Santarelli, Jiri Neuzil (2014) MicroRNA-126 Suppresses Mesothelioma Malignancy by Targeting IRS1 and Interfering with Mitochondrial Function. Antioxidants & Redox Signaling 01/2014.
5. Hyo-Jin Jeong, Seung-Yoon Park, Won-Mo Yang, Wan Lee (2013) The induction of miR-96 by mitochondrial dysfunction causes impaired glycogen synthesis through translational repression of IRS-1 in cultured hepatoma cells. Biochemical and Biophysical Research Communications 434(3): 503-508.
6. Seung-Yoon Park, Hyo-Jin Jeong, Won-Mo Yang, Wan Lee (2013) Implications of microRNAs in the pathogenesis of diabetes. Archives of Pharmacal Research 36(2): 154-166.
7. Eun-Ju Park, Mi-Jin Kim, Wan Lee, Seung-Yoon Park (2012) Ets-2 is involved in transcriptional regulation of C1qTNF-related protein 5 in muscle cells. Molecular Biology Reports  39(10): 9445-9451.
8. Mi-Jin Kim, Eun-Ju Park, Wan Lee, Jung-Eun Kim, Seung-Yoon Park (2012) Regulation of the transcriptional activation of CTRP3 in chondrocytes by c-Jun. Molecular and Cellular Biochemistry 368(1-2): 111-117.
9. Mi-Jin Kim, Wan Lee, Eun-Ju Park, Seung-Yoon Park (2012) Depletion of mitochondrial DNA stabilizes C1qTNF-related protein 6 mRNA in muscle cells. Journal of Korean Medical Science 27(5): 465-470.
10. Hyun Su Ryu, Seung-Yoon Park, Duan Ma, Jin Zhang, Wan Lee (2011) The induction of microRNA targeting IRS-1 is involved in the development of insulin resistance under conditions of mitochondrial dysfunction in hepatocytes. PLoS ONE  6(3): e17343.
11. Hyun-Ho Hwang, Pyong-Gon Moon, Jeong-Eun Lee, Jung-Guk Kim, Wan Lee, Sung-Ho Ryu, Moon-Chang Baek (2011) Identification of the target proteins of rosiglitazone in 3T3-L1 adipocytes through proteomic analysis of cytosolic and secreted proteins. Molecules and Cells 31(3): 239-246.
12. Mi-Jin Kim, Wan Lee, Eun-Ju Park, Seung-Yoon Park (2010) Role of hepatocyte nuclear factor-4alpha in transcriptional regulation of C1qTNF-related protein 5 in the liver. FEBS letters 584(14): 3080-3084.
13. Wan Lee, Mi-Jin Kim, Eun-Ju Park, Young-Jin Choi, Seung-Yoon Park (2010) C1qTNF-related protein-6 mediates fatty acid oxidation via the activation of the AMP-activated protein kinase. FEBS letters 584(5): 968-972.
14. Wan Lee, Hyo Im Choi, Mi Jin Kim, Seung Yoon Park (2008) Depletion of mitochondrial DNA up-regulates the expression of MDR1 gene via an increase in mRNA stability. Experimental and Molecular Medicine 40(1): 109-117.
15. Seung Y Park, Yoo H Choi, Wan Lee (2008) Dangnyohwan improves glucose utilization and reduces insulin resistance by increasing the adipocyte-specific GLUT4 expression in Otsuka Long-Evans Tokushima Fatty rats. Journal of Ethnopharmacology 115(3): 473-482.
16. Young Ok Choi, Jong-Ha Park, Young Sook Song, Wan Lee, Yoshinori Moriyama, Han Choe, Chae Hun Leem, Yeon Jin Jang (2008) Involvement of vesicular H+-ATPase in insulin-stimulated glucose transport in 3T3-F442A adipocytes. Endocrine Journal 54(5): 733-743.
17. Seung Y Park, and Wan Lee (2007) The depletion of cellular mitochondrial DNA causes insulin resistance through the alteration of insulin receptor substrate-1 in rat myocytes. Diabetes Research and Clinical Practice 77 Suppl 1: S165-S171.
18. Seung Y. Park, Sanghyun Lee, Kyong S. Park, Hong K.Lee and Wan Lee(2006) Proteomic Analysis of Cellular Change Involved in Mitochondria-to-Nucleus Communication in L6 GLUT4myc Myocytes. Proteomics6, 1210-1222.
19. Young O. Choi, Hee J. Ryu, Hye R. Kim, Young S. Song, Cheon H. Kim, Wan Lee, Han Choe, Chae H. Leem, and Yeon J. Jang (2006) Implication of phosphorylation of the myosin II regulatory light chain in insulin-stimulated GLUT4 translocation in 3T3-F442A adipocytes. Exp. Mol. Med. 38: 180-189.
20. Seung Y. Park, Guem H. Choi, Hyo I. Choi, Jiwon Ryu, Chan Y. Jung, and Wan Lee(2005) Depletion of mitochondrial DNA causesimpaired glucose utilization andinsulin resistance in L6 GLUT4myc myocytes. J. Biol. Chem. 280(11), 9855-9864.