Journal of Cancer Therapy
Vol.4 No.5(2013), Paper ID 33772, 9
pages
DOI:10.4236/jct.2013.45106
Bicarbonate Attenuates Irinotecan-Induced Cytotoxicity through Regulation of Both Extracellular and Intracellular pHs in Intestine Cell Line
Teruo Miyazaki, Tadashi Ikegami, Yoshiaki Nagai, Amy Nguyen, Yasushi Matsuzaki, Kunihiko Kobayashi, Susan Ceryak
Joint Research Center, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan
Department of Respiratory Medicine, Saitama International Medical Center, Saitama Medical University, Hidaka, Saitama, Japan
Department of Biochemistry and Molecular Biology, The George Washington University, Washington DC, USA
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ami, Ibaraki, Japan
Department of Respiratory Medicine, Saitama International Medical Center, Saitama Medical University, Hidaka, Saitama, Japan
Department of Pharmacology, The George Washington University, Washington DC, USA
Copyright © 2013 Teruo Miyazaki, Tadashi Ikegami, Yoshiaki Nagai, Amy Nguyen, Yasushi Matsuzaki, Kunihiko Kobayashi, Susan Ceryak et al. This is
an open access article distributed under the Creative Commons Attribution
License, which permits unrestricted use, distribution, and reproduction in any
medium, provided the original work is properly cited.
How to Cite this Article
T. Miyazaki, T. Ikegami, Y. Nagai, A. Nguyen, Y. Matsuzaki, K. Kobayashi and S. Ceryak, "Bicarbonate Attenuates Irinotecan-Induced Cytotoxicity through Regulation of Both Extracellular and Intracellular
pHs in Intestine Cell Line,"
Journal of Cancer Therapy, Vol. 4 No. 5, 2013, pp. 944-952. doi:
10.4236/jct.2013.45106.