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  • 186pp. Published September 2018
  • Scientific Research Publishing,Inc.,USA
  • Category: Medicine & Healthcare
  • ISBN: 978-1-61896-569-1
  • (Paperback) USD 69.00
  • ISBN: 978-1-61896-570-7
  • (E-Book) USD 19.00

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Home > Books > Advances in Aging and Health Research
Advances in Aging and Health Research
  • Description
  • E-Book
  • Author(s) Information

In the current global epidemic for chronic diseases such as non alcoholic fatty liver disease (NAFLD), obesity, diabetes and neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease have become of major concern to the developed and developing world. Appetite regulation is involved in the aging process with the repression of anti-aging genes connected to insulin resistance and neurodegenerative diseases. Interests in the gene-environment interactions indicate that the anti-aging genes are connected to the metabolism of bacterial lipopolysaccharides (LPS), drugs and xenobiotics. In the developing world relevance to gram negative bacteria and increased plasma bacterial lipopolysaccharides (LPS) outer membrane endotoxins bindto cell membranes and interfere with cholesterol and amyloid beta (Aβ) interactionswith repression of anti-aging genes to mediate accelerated neuron death. Biotherapeutics and nutritional biotherapy have become important to reverse these global chronic diseases. Biotherapeutics that involve Indian spice therapy require reassessment with relevance to insulin therapy, immunotherapy, antimicrobial therapy and drug therapeutics. Combined insulin and Indian spice therapy interferes with human insulin biological activity relevant to the prevention of uncontrolled intracellular glucose levels and mitochondrial apoptosis. Magnesium therapy reverses cell senescence associated with various chronic diseases such as cardiovascular disease, diabetes and Alzheimer’s disease. Factors such as stress, core body temperature and food quality influence biotherapeutics with prevention of NAFLD, diabetes and neurodegenerative diseases.

Components of the Book:
  • FRONT MATTER
    • Head Page
    • Copyright
  • Preface
  • Acknowledgements
  • Short Biography
  • Contents
  • Chapter 1 Sirtuin-1 Mediates the Obesity Induced Risk of Common Degenerative Diseases: Alzheimer’s Disease, Coronary Artery Disease and Type 2 Diabetes
    • 1. Introduction
    • 2. Obesity and Adiposity
    • 3. Midlife Obesity
    • 4. Diet and Risk of Alzheimer’s Disease
    • 5. Leptin and Obesity
    • 6. Insulin and Obesity
    • 7. Sirtuin 1
    • 8. Sirtuin 1 and the Amyloid Precursor Protein (APP) of Alzheimer’s Disease
    • 9. Obesity, the Endoplasmic Reticulum and Alzheimer’s Disease
    • 10. Conclusions
    • References
  • Chapter 2 The Acceleration of Aging and Alzheimer’s Disease through the Biological Mechanisms Behind Obesity and Type II Diabetes
    • 1. Background
    • 2. Convergence of Mechanisms Linking Obesity to Diabetes and Acceleration of Aging and Alzheimer’s Disease
    • 3. Lifestyle, Diet and Drug Connections to Diabetes and Alzheimer’s Disease
    • 4. Nutritional Science and Drugs Delay Obesity and Severity of Diabetes Linked to Aging and Alzheimer’s Disease
    • 5. Conclusions
    • References
  • Chapter 3 LPS Regulates Apolipoprotein E and Aβ Interactions with Effects on Acute Phase Proteins and Amyloidosis
    • 1. Introduction
    • 2. LPS Neutralize Apo E Binding to Membrane Lipids with Effects on Peripheral Aβ Metabolism
    • 3. Hepatic Release of Acute Phase Proteins and Cytokines Is Regulated by LPS with Abeta Aggregation
    • 4. Conclusions
    • Acknowledgements
    • Abbreviations
    • References
  • Chapter 4 Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations
    • 1. Introduction
    • 2. Repression of Anti-Aging Genes Determine Food Intake Regulation, Insulin Resistance and Neurodegenerative Disease
    • 3. Dysregulation of Neuropeptides and Endocrine Hormones by LPS Determine Appetite and Metabolism Disorders
    • 4. Anti-Aging Therapy Involves Reversal of Appetite Disorders in Autonomous Chronic Diseases
    • 5. Discussion
    • 6. Conclusions
    • Acknowledgements
    • References
  • Chapter 5 Magnesium Therapy Prevents Senescence with the Reversal of Diabetes and Alzheimer’s Disease
    • 1. Introduction
    • 2. Magnesium Therapy Regulates Amyloid Beta Metabolism with Implications for NAFLD and Cardiovascular Disease
    • 3. LPS Disrupts Magnesium Therapy with Relevance to Albumin and Amyloid Beta Oligomer Metabolism
    • 4. Unhealthy Diets, Exercise and Stress Prevent Magnesium Therapy and Accelerate Chronic Diseases
    • 5. Conclusions
    • Acknowledgements
    • References
  • Chapter 6 Indian Spices and Biotherapeutics in Health and Chronic Disease
    • 1. Editorial
    • 2. Conclusions
    • Acknowledgements
    • References
Readership: People who are interested in aging and health research.
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