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  • 120pp. Published January 2018
  • Scientific Research Publishing, Inc., USA.
  • Category: Medicine & Healthcare
  • ISBN: 978-1-61896-447-2
  • (Paperback) USD 59.00
  • ISBN: 978-1-61896-448-9
  • (E-Book) USD 9.00

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Home > Books > Management of Rheumatoid Arthritis: From...
Management of Rheumatoid Arthritis: From the Perspective of Complex Network
  • Description
  • E-Book
  • Author(s) Information

Before the system theory came into being, our understanding of biology is still based on the basis of decomposition and reduction. If we're stuck in reductionism, many complex autoimmune diseases, such as Rheumatoid arthritis (RA), will be difficult to understand. With the emergence of complex networks in 1989, understanding of biological networks has been enhanced. In this book the author presents the management strategy of RA from the perspective of complex network.


RA is the most common chronic autoimmune joint disease. This book argues that the RA is mainly caused by chronic stress and stress factors include physical and psychological stress. Existing statistical techniques based on reductionism cannot discover many relevant disease risk factors and complex interaction relationship. The disease network model based on complex network is important for the analysis and treatment of RA disease.


In this book, the author have found five important layers of RA complex network and presented five balances regulating strategy in the management of RA. Using this method, the author takes a two-year follow-up to check the effect.


This Book argues RA is selflimiting to some extent, and good management with five balances regulating strategy would have positive significance, among which the balance between neuroendocrine system and immune system is the most important. All five balances regulating strategy are important for RA with other causes besides the RA case in the book.

Components of the Book:
  • FRONT MATTER
  • Chapter 1. Five Balances in the Management of Rheumatoid Arthritis
    • 1. Introduction
    • 2. Method
    • 3. Five Balances in the Management of Rheumatoid Arthritis
    • 4. Case Study
    • 5. Summary
    • References
  • Chapter 2. Etiology of Rheumatoid Arthritis
    • 1. Degradation of Thymus
    • 2. Stress Response
    • 3. Chronic Inflammation
    • 4. Immune Response
    • 5. Type III Hypersensitivity
    • 6. Local Joint Inflammation
    • 7. Microcirculation
    • 8. Ischemia-Reperfusion Injury
    • 9. Glucocorticoid (GC) and Growth Hormone (GH)
    • References
  • Chapter 3. Immune System from the Perspective of Complex Network
    • 1. Empirical Study of Immune System Based on Bipartite Network
    • 2. Community in Immune System
    • 3. Complex Network Model of Cytokine-Protein Network
    • References
  • Chapter 4. Neuroendocrine Immune System from the Perspective of Complex Network
    • 1. Neuroendocrine System from the Perspective of Complex Network
    • 2. Prediction of Protein-Protein Interaction in Neuroendocrine System
    • 3. Complex Network Research of Neural-Immune System
    • References
  • Chapter 5. Management of Rheumatoid Arthritis: From the Perspective of Complex Network
    • 1. About Balance between Neuroendocrine System and Immune System
    • 2. About Balance between Pro-Inflammatory Cytokine and Anti-Inflammatory Cytokine
    • 3. About Balance between Th17 and Treg
    • 4. About Balance between Exercise and Rest
    • 5. About Balance between Body’s Immune System and Local Joint Inflammation
    • References
Readership: Researchers of rheumatoid arthritis and other rheumatism field;rheumatic patients.
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