Study of Safety of Molybdenum and Iron-Molybdenum Nanoclaster Polyoxometalates Intended for Targeted Delivery of Drugs

Alexander A. Ostroushko, Irina G. Danilova, Irina F. Gette, Svetlana Yu. Medvedeva, Margarita O. Tonkushina, Anna V. Prokofieva, Maria V. Morozova

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DOI: 10.4236/jbnb.2011.225066                

Abstract

Nanocluster polyoxometalates with a structure of buckyball (fullerene) are a promising means of targeted delivery of drugs in the body. In this paper, based on an analysis of histological sections of liver and kidney and peripheral blood, showed a significant reduction of toxicity of buckyballs, containing ions of molybdenum (VI), the substitution of Mo (V) ions to Fe (III), in contrast to buckyballs based on Mo (V). The absence of accumulation of molybdenum in rats with a daily intramuscular injection of aqueous solutions of both drugs within a month was confirmed.

Keywords

Buckyball, Polyoxometalates, Direct Delivery, Toxicity

Conflicts of Interest

The authors declare no conflicts of interest.

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