The molecular mechanism for DDT detoxification in Anopheles gambiae: A molecular docking study

William N. Setzer

Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.

DOI: 10.4236/jbpc.2011.22016                

Abstract

The epsilon class glutathione-S-transferase of Anopheles gambiae, agGSTe2, is capable of metabolizing DDT. A molecular docking analysis of DDT with agGSTe2 support an E2 elimination mechanism wherein the glutathione sulfur serves as the base to convert DDT to DDE.

Keywords

Malaria; DDT; Anopheles Gambiae; Glutathione S-transferase; Docking

Conflicts of Interest

The authors declare no conflicts of interest.

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