Possible mechanism of increasing resistance of the myocardium during combination of post infarction remodeling and diabetes mellitus

M. V. Egorova, S. A. Afanasiev, D. S. Kondratyeva, B. N. Kozlov, S. V. Popov

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DOI: 10.4236/ns.2011.34038                

Abstract

It was shown that the energy metabolism of the heart mitochondria of experimental animals and patients is more resistant to damage at combined postinfarction cardiosclerosis and diabetes in comparison with the individual pathology. We found that the changes of free fatty acid content and conjugation of the processes of oxidation and phosphorylation in heart mitochondria are components of the metabolic stability of myocardium at the combined development of postinfarction cardiosclerosis and diabetes mellitus. Our data demonstrate a direct link between the violations of the processes of oxidative phosphorylation and accumulation of free fatty acids owing to change in activity of endogenous phospholipases, in particularly, mi- tochondrial phospholipase A2. Similar results were obtained for intraoperative biopsy specimens of patients’ hearts, and of adult Wistar rats’ hearts. We hypothesized that the preservation of energy metabolism is a manifestation of summing up of compensatory processes at de- velopment of nonspecific response of cells to damage at the early stages of pathological pro- cess.

Keywords

Postinfarction Remodeling; Diabetes; Heart Mitochondria; Fatty Acids; Phospholipase A2

Conflicts of Interest

The authors declare no conflicts of interest.

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