Protective Effects of Many Citrus Flavonoids on Cartilage Degradation Process

Lucia Crascì, Annamaria Panico

Department of Drug Sciences, Faculty of Pharmacy, University of Catania, Catania, Italy..

DOI: 10.4236/jbnb.2013.43035                

Abstract

The objective of this study was to investigate the effects of many citrus flavanones, such as neoeriocitrin, naringin and neohesperidin, in cartilage degradation. Degenerative joint disease involved degradation of joints, including articular cartilage and subchondral bone. When bone surfaces become less well protected by cartilage, bone may be exposed and damaged. The degradation cartilage is mediated by alteration of the balance between anabolic and catabolic processes, changes in proteolytic enzyme activity, mechanical disruption of the cartilage extracellular matrix (ECM), or a combination of these processes. We examine the capability of neoeriocitrin, naringin and neohesperidin, to inhibit metalloproteinase (MMP)-13, collagenase involved in degradation of cartilage matrix components. Also, we assay the flavonoids effect on reducing of Glycosaminoglycans (GAGs) release, and restore Nitric oxide (NO) levels in explant of human articular cartilage. Our results suggest that neoeriocitrin, naringin and neohesperidin are a potential therapeutic agent to protect cartilage tissue.

Keywords

Neoeriocitrin; Naringin; Neohesperidin; Metalloproteinases-13; Cartilage Degradation

Conflicts of Interest

The authors declare no conflicts of interest.

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