Decreasing serum uric acid levels are associated with improving estimated glomerular filtration rate (eGFR) in Japanese women

Nobuyuki Miyatake, Kenichi Shikata, Hirofumi Makino, Takeyuki Numata

Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan.
Department of Hygiene, Faculty of Medicine, Kagawa University, Miki, Japan.
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Okayama Southern Institute of Health, Okayama Health Foundation, Okayama, Japan.

DOI: 10.4236/ojepi.2013.32007                

Abstract

The aim of this study was to investigate the link between changes in a subject’s serum uric acid levels and the estimated glomerular filtration rate (eGFR) in Japanese women. We used data for 161 Japanese women (49.8 ± 11.7 years) with a 1-year follow up. eGFR was defined by a new equation developed for Japan. eGFR was negatively correlated with serum uric acid levels (r = -0.402, p < 0.0001) at baseline. Subjects were given advice for dietary and lifestyle improvement. At the 1-year follow up, abdominal circumference and systolic blood pressure (SBP) were significantly improved. However, uric acid and eGFR did not change. The changes in eGFR were negatively correlated with uric acid (r = -0.475, p < 0.0001). A decrease in serum uric acid levels was associated with improving eGFR in Japanese women.

Keywords

Uric Acid; Estimated Glomerular Filtration Rate (eGFR); Lifestyle Modification; Blood Pressure (BP)

Conflicts of Interest

The authors declare no conflicts of interest.

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