Advancements in Suppression of Osteosarcoma Tumorigenicity: A Prospective Look

Lin Wang, Paul Park, Frank La Marca, Khoi Than, Shayan Rahman, Chia-Ying Lin

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan, USA.

DOI: 10.4236/jct.2012.34042                

Abstract

Bone morphogenetic proteins (BMPs) promote differentiation of stem cells into bone cells. Results from our pilot studies indicate these proteins are also capable of inducing the differentiation of stem-like cells that initiate and propagate osteosarcoma, a rare, highly malignant primary bone tumor affecting primarily children and adolescents. Our plans to evaluate the use of BMP as adjuvant therapy to suppress bone tumor while facilitating skeletal reconstruction are reviewed.

Keywords

BMP-2; Osteosarcoma; Cancer Stem Cells; Aldehyde Dehydrogenase

Conflicts of Interest

The authors declare no conflicts of interest.

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