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The Efficacy of Hyaluronic Acid in the Restoration of Soft Tissue Volume of the Lips and Lower 1/3 of the Face: The Evolution of the Injection Technique

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DOI: 10.4236/jcdsa.2011.14022    5,643 Downloads   9,336 Views   Citations

ABSTRACT

Study objective: To establish the safety and efficacy of small-gel particle hyaluronic acid (SGP-HA; Restylane®, Medicis Aesthetics Inc., Scottsdale, AZ) for lip augmentation. Study design: This was a Phase 3, prospective, open-label, evaluator-blinded, single-center pilot study of SGP-HA use in lip augmentation. The primary efficacy objectives were to investigate the efficacy of SGP-HA in lip augmentation and to assess subject satisfaction with the procedure 12 weeks after treatment. Secondary efficacy objectives were to validate 3D imaging to measure lip augmentation, identify subject satisfaction at all points in time, and identify the duration of lip augmentation and palpability of SGP-HA in the lips. The primary safety objective was to assess the incidence, duration, and severity of all adverse experiences. Results: All 20 subjects and the treating investigator indicated improvement in the appearance of subjects’ lips at weeks 2, 6, and 12. SGP-HA administered for augmentation was well tolerated. Four (20%) subjects treated with SGP-HA experienced 7 treatment-emergent adverse events (TEAEs). Conclusions: Results of this study show promising efficacy and an absence of safety issues with the use of SGP-HA in lip augmentation.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

A. Klein, "The Efficacy of Hyaluronic Acid in the Restoration of Soft Tissue Volume of the Lips and Lower 1/3 of the Face: The Evolution of the Injection Technique," Journal of Cosmetics, Dermatological Sciences and Applications, Vol. 1 No. 4, 2011, pp. 147-152. doi: 10.4236/jcdsa.2011.14022.

References

[1] N. Etcoff, “Survival of the Prettiest: The Science of Beauty,” Doubleday, New York, 1999.
[2] K. M. Robertson, W. K. Dyer and W. K. Dyer II, “The Use of Fillers in the Aging Patient,” Facial Plastic Surgery, Vol. 12, No. 3, 1996, pp. 293-301. doi:10.1055/s-0028-1082420
[3] A. W. Klein, F. D. Brandt, D. A. Grekin and H. Mittleman, “Collagen Implants for Lip Augmentation,” Journal of Dermatologic Surgery and Oncology, 1990.
[4] A. W. Klein, “Injectable Collagen: A Tutorial,” In: L. M. Dzubow, Ed., Cosmetic Dermatologic Surgery, Lippincott-Raven, Philadelphia, 1998, pp. 19-34.
[5] A. W. Klein, “Injectable Bovine Collagen,” In: A. W. Klein, Ed., Tissue Augmentation in Clinical Practice, Marcel Dekker, New York, 1998, pp. 125-144.
[6] J. O. Guerrissi, “Surgical Treatment of the Senile Upper Lip,” Plastic and Reconstructive Surgery, Vol. 106, No. 4, 2000, pp. 938-940. doi:10.1097/00006534-200009040-00036
[7] S. S. Ergun, D. I. Cek, H. Baloglu, Z. Algun and H. Onay, “Why Is Lip Augmentation with Autologous Fat Injection Less Effective in the Vermilion Border?” Aesthetic Plastic Surgery, Vol. 25, No. 5, 2001, pp. 350-352. doi:10.1007/s00266-001-0020-z
[8] S. A. Castor, W. C. To and F. A. Papay, “Lip Augmentation with Allo Derma Cellular Allogenic Dermal Graft and Fat Auto Graft: A Comparison with Autologous Fat Injection Alone,” Aesthetic Plastic Surgery, Vol. 23, No. 3, 1999, pp. 218-223.
[9] C. Le Louarn, “[Botulinum Toxin and Facial Wrinkles: A New Injection Procedure] Toxine Botulique et Rides Facials: Une Nouvelle Procedure d’Injection,” Annales de Chirurgie Plastique et Esthetique, Vol. 43, No. 5, 1998, pp. 526-533.
[10] G. Felman, “Direct Upper-Lip Lifting: A Safe Procedure,” Aesthetic Plastic Surgery, Vol. 17, No. 4, 1993, pp. 291-295. doi:10.1007/BF00437101
[11] G. Flageul and L. Halimi, “Injectable Collagen: An Evaluation after 10 Year’s Use as a Complement of Plastic Surgery. Le Collagene Injectable: Bilan après 10 Ans d’Utilisation en Complement de la Chirurgie Esthetique,” Annales de Chirurgie Plastique et Esthetique, Vol. 39, No. 6, 1994, pp. 765-771.
[12] B. P. Maloney, “Cosmetic Surgery of the Lips,” Facial Plastic Surgery, Vol. 12, No. 3, 1996, pp. 265-278.
[13] R. S. Narins, F. Brandt, J. Leyden, Z. P. Lorenc, M. Rubin and S. Smith, “A Randomized, Double-Blind, Multicenter Comparison of the Efficacy and Tolerability of Restylane versus Zyplast for the Correction of Nasolabial Folds,” Dermatologic Surgery, Vol. 29, No. 6, 2003, pp. 588-595.
[14] P. Friedman, et al., “Safety Data of Injectable Nonanimal Stabilized Hyaluronic Acid Gel for Soft Tissue Augmentation,” Dermatologic Surgery, Vol. 28, No. 6, 2002, pp. 491-494. doi:10.1046/j.1524-4725.2002.01251.x
[15] S. Schanz, et al., “Arterial Embolization Caused by Injection of Hyaluronic Acid (Restylane),” British Journal of Dermatology, Vol. 146, No. 5, 2002, pp. 928-929.
[16] D. D. Waddell, “Acute Reaction to Intra-Articular Hylan G-F,” Journal of Bone and Joint Surgery, Vol. 85. No. 8, 2003, p. 1620.
[17] A. Oswald and A. Gachter, “Acute Reaction to Intra-Articular Hylan G-F for Treatment of Gonarthrosis Onset,” Schweizerische Rundschau für Medizin Praxis, Vol. 89. No. 46, 2000, pp. 1929-1931.
[18] R. Rifkin, “Restoring Vertical Dimension to Improve Function, Facial Harmony, and Dental Esthetics,” Contemporary Esthetics and Restorative Practice, 2004, pp. 40-46.
[19] E. A. McLaren and R. Rifkin, “Macroesthetics: Facial and Dentofacial Analysis,” Journal of the Canadian Dental Association, Vol. 30. No. 11, 2002, pp. 839-846.
[20] J. Niamtu, “Cosmetic Oral and Maxillofacial Surgery: The Frame for Cosmetic Dentistry,” Dentistry Today, Vol. 20, No. 4, 2001 pp. 88-91.
[21] J. T. Cheng, S. W. Perkins and M. M. Hamilton, “Perioral Rejuvenation,” Facial Plastic Surgery, Vol. 8, No. 2, 2000, pp. 223-323.
[22] M. L. Elson, “Anesthesia for Lip Augmentation,” Dermatologic Surgery, Vol. 23, No. 5, 1997, p. 405.
[23] A. W. Klein and B. W. Ayers, “Lip Augmentation,” In: Sherrel J. Aston Ed., Aesthetic Plastic Surgery, Elsevier BV, Amsterdam, 2009, pp. 855-860.
[24] A. W. Klein, “Soft Tissue Augmentation 2006: Filler Fantasy,” Dermatologic Therapy, Vol. 19, No. 3, 2006, pp. 129-133. doi:10.1111/j.1529-8019.2006.00066.x
[25] A. A. Jacono, “A New Classification of Lip Zones to Customize Injectable Lip Augmentation,” Archives of Facial Plastic Surgery, Vol. 10, No. 1, 2008, pp. 25-29. doi:10.1001/archfaci.10.1.25
[26] J. Carruthers, A. W. Klein, A. Carruthers, R. G. Glogau, and D. Canfield, “Safety and Efficacy of Nonanimal Stabilized Hyaluronic Acid for Improvement of Mouth Corners,” Dermatologic Surgery, Vol. 31, No. 3, 2005, pp. 276-280. doi:10.1111/j.1524-4725.2005.31073

  
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