Epidemiological Profile and Therapeutics Results of Bladder Carcinoma in Women ()
1. Introduction
Bladder cancer occurs at an average age of 65 and the male/female ratio is estimated to be 4.8:1 [1]. However, the incidence of this disease in women has steadily increased in recent years.
Smoking is the main risk factor, and gross hematuria is the revealing symptom in more than 80% of cases.
The standard treatment is anterior pelvectomy in women; but given the morbidity and mortality associated with this surgery, as well as the deterioration in quality of life, patients must be selected for trimodal treatment.
We report here a series collected within the Mohamed VI center for cancer treatment; in order to study the epidemiological profile of bladder cancer in women in our population, the factors favoring its occurrence and its suggestive signs.
2. Methods
This is a retrospective study of twenty-seven patients followed for bladder cancer at the Mohamed VI Cancer Treatment Center. These patients were collected over a two-year period; January 2019 to December 2020.
Our hospital center uses a computerized system “Enova” to record all data concerning the patient and her pathology: identity, medical history, and initial clinical, paraclinical and anatomopathological assessment. It also contains the therapeutic decision after a multidisciplinary consultation meeting and the post-therapeutic results.
Epidemiological and therapeutic data were collected on an excel file from the computerized medical records of the patients followed regularly in consultation after the end of their treatment.
3. Results
Twenty-seven patients were collated. The average age was 67.5 years with extremes ranging from 45 to 100 years. 66.66% of the patients were over 65 years old.
3 patients in our series were smokers. 25.9% were diabetic, and 18.5% were followed for high blood pressure.
We found the notion of recurrent urinary tract infections (cystitis) in one patient. But no case of bilharzia has been detected. A patient was treated for an upper excretory tract tumor, two patients had an associated renal tumor, and no case of bladder or renal lithiasis was found in our series.
The time to treatment was less than 6 months in 44.4% of cases, between 6 and 12 months in 18.5% of cases, and more than a year in 37% of cases. The symptoms were marked by hematuria in 96.3% of cases, and irritative disorders in 81.4% of cases.
The site of the tumor in order of frequency was as follows: the posterior wall in 37% of the cases, the latéro-left wall in 25.9% of the cases. The walls; anterior, latéro-right and the entire bladder were affected in 11.11% of cases for each of them.
In our series, the tumor was unifocal in 77.77% of the cases, and multifocal in the remainder of the cases. Urethrohydronephrosis was found in 74% of cases.
Histologically, it was an urothelial carcinoma in 81.48% of cases, of which the component of squamous and micropapillary carcinoma was found in 13.6% of cases. Other less frequent histological type’s adenocarcinoma type in 7.4% of cases, muciparous kitten ring carcinoma in 3.7% of cases, and pure squamous cell carcinoma in 3.7% of cases.
The extension assessment made it possible to classify patients with locally advanced stage in 11.11% of cases, and metastatic in 11.11% of cases. Lymph node involvement was found in 33.33% of cases.
48.1% of cases underwent surgery. The operative procedure consisted of partial cystectomy in 46.1% of cases, total cystectomy with ureterostomy in 38.5% of cases, and total cystectomy with neo-bladder in 15.4% of cases. Just 30.7% of patients received neoadjuvant chemotherapy during surgery. However, all the operated patients; received adjuvant chemotherapy-type treatment in 92.3% of cases and radiotherapy in one patient given the R1 resection of the tumor (Figure 1 and Figure 2).
In our study population, only 18.5% were suitable for trimodal treatment (Figure 1).
The follow-up is based on clinical examination, thoraco-abdomino-pelvic scanner and cystoscopy in case of trimodal treatment every 3 - 4 months during the first year and every 6 months during the second and third year.
Our average follow-up was 25 months, a relatively low follow-up linked to a large number of lost to follow-up in 40.7% of cases. However; 29.6% are progressing, 18.5% are in remission, and only one death according to the available data.
4. Discussion
The incidence of bladder tumors in women is increasing worldwide.
Smoking is the most important factor [2]. In fact, the risk of developing bladder cancer is 2 to 4 times higher in smokers compared to non-smokers and this risk increases with the intensity and/or duration of smoking [3] [4]. In our series, 11.11% of patients were exposed to tobacco.
Environmental factors have been associated with an increased risk of developing bladder cancer; to know; drinking water disinfection techniques using chlorine with a relative risk of 1.7 to 3.1 with respect to bladder cancer [5]. Exposure to urothelial carcinogens in particular; to aromatic amines [6] [7], as well as to polycyclic aromatic hydrocarbons [8], whether recent or old.
McGrath and colleagues (2006) reported an increased risk of bladder cancer in postmenopausal women (p = 0.30). Hormone replacement therapy during menopause and late menopause at age 48 or older has been shown to protect against bladder cancer [9] [10].
Other authors suggest that the prevalence of pathologies affecting bladder emptying increases with age such as genital prolapse in women [11]. Causes chronic urinary stasis which is associated with an increase in the contact time of carcinogens with the urothélium, again promoting its carcinogenesis [12].
Hematuria is the main sign of bladder cancer and is often present. But we noticed that our elderly patients had longer diagnostic times; and this due according to studies the increase in the prevalence of hematuria secondary to taking antiplatelet agents or anticoagulants according to Bhatt et al. in the elderly population [13], and the underestimation of hematuria given the frequency of benign causes of hematuria which increases with age, mainly concerning genital prolapse in women [11] and urinary tract infections [14]. What led to American college of physicians to recommend no longer interpret hematuria as a consequence of antiaggregant or anticoagulant treatment but systematically look for a cause, in particular tumor [15].
The standard treatment for muscle-infiltrating urothelial bladder tumors is based on neoadjuvant chemotherapy based on platinum salts followed by anterior pelvectomy in women with evidently ilio-obturator lymph node dissection [16]. It is a heavy and complex surgery, in particular in elderly patients and/or suffering from significant associated diseases. The morbidity and mortality associated with this intervention remains high, with a complication rate between 40% and 60% and a mortality rate of 9% in the first three months postoperatively [17] [18]. In addition, patients who have had a cystectomy suffer from an impaired quality of life regardless of the mode of urinary diversion, both urinary, digestive or sexual [19].
However; phase II pilot trials validated trimodal treatment in selected patients; combining the most complete possible transurethral resection of the tumor followed by concomitant chemoradiotherapy. Radiotherapy was administered up to a dose level of 40 to 45 Gy, with concomitant cisplatin in various modalities, with or without 5-fluorouracil, followed 5 to 6 weeks later by cystoscopy with biopsies control of the tumor bed. Patients in complete histological remission received additional chemoradiotherapy up to a total dose of 55 to 65 Gy. In contrast; a cystectomy was offered to patients with a tumor residue [20] [21].
After trimodal treatment; 5-year bladder retention rates were between 40 and 80% in the recent series [22] [23] [24]. As well as currently, we have recent meta-analyses and reviews of the literature which did not show a significant difference in terms of survival between the concomitant chemoradiotherapy arm and the surgery arm with a p = 0.32 [25] [26].
5. Conclusions
Few studies have addressed the epidemiology of bladder cancer in women due to the low incidence, but it is currently increasing steadily in recent years.
The advanced age of onset and the frequency of etiologies of benign hematuria in elderly women explain the late diagnosis in this population, hence the interest in systematizing cystoscopy.