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A Novel Dihydropyridines C-Glycosylated Compound by Hantzsch Cyclo-Condensation

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DOI: 10.4236/ojsta.2018.72002    303 Downloads   504 Views


The Hantzsch synthesis has been used for the preparation of the 1,4-Dihydropyridines compounds with different pharmacophore groups. The use of a designed glycosylated compound in Hantzsch synthesis would lead to a novel Dihydropyridines C-Glycosylated compound. We used the 6-methoxy-2, 2-dimethyltetrahydrofuro [3, 4-d] [1, 3] dioxole-4-carbaldehyde as a glycosylated-based aldehydes. The 4-(3,4-Dihydroxy-5-methoxy-tetrahydro-furan-2-yl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxy-lic acid 3-ethyl ester 5-methyl ester was synthesized. The structure of compounds was determined by NMR spectroscopy, FTIR and mass spectroscopy methods. We synthesized this 1,4-Dihydropyridines compound by ionic liquid under ultrasound irradiation as a green chemistry synthesis.

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Sedaghat, S. and Madjdpour, S. (2018) A Novel Dihydropyridines C-Glycosylated Compound by Hantzsch Cyclo-Condensation. Open Journal of Synthesis Theory and Applications, 7, 17-29. doi: 10.4236/ojsta.2018.72002.

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