Author(s)

Mingqing Wei^1*, Xuekai Zhang^1*, Jing Shi^1*, Jingnian Ni¹, Ting Li¹, Tao Lu², Yuanyuan Shi², Liping Zhang³, Pengwen Wang⁴, Shenghua Kang¹, Fuyun Ma¹, Yumeng Li¹, Chenmeng Li¹, Jinzhou Tian¹

¹BUCM Neurodegenerative Diseases Center, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
²School of Life Science, Beijing University of Chinese Medicine, Beijing, China.
³Department of Radiology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
⁴Key Laboratory of Pharmacology of Chinese Materia Medica, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.

Background: Although Alzheimer’s disease (AD) has been intensively investigated for many years, the effective treatments are largely missing. Commonly used conventional therapy, such as cholinesterase inhibitors (ChEI) and N-methyl D-asparate receptor antagonist, have been generally considered as having symptom-relieving rather than disease-modifying effects. Thus, how to improve cognitive function beyond such effect & time limitations has become a serious challenge. Aim: In order to solve this challenge, a sequential therapy with the integration of conventional therapy and herbal therapy was applied to AD patients. Careful clinical observation was conducted in our outpatient setting. Case Presentation: A case of probable AD received the sequential therapy has achieved relative stable cognition and overall status in eight years. Conclusion: During the treatment of this AD case in eight years, sequential therapy showed great potential in stabilizing and improving cognition and overall status. Well designed preclinical and clinical studies are needed to investigate the efficacy of sequential therapy for AD and other type of dementia.

Alzheimer’s Disease, Sequential Therapy, Cholinesterase Inhibitors, Herbal Medicine

Wei, M. , Zhang, X. , Shi, J. , Ni, J. , Li, T. , Lu, T. , Shi, Y. , Zhang, L. , Wang, P. , Kang, S. , Ma, F. , Li, Y. , Li, C. and Tian, J. (2017) A Case of Alzheimer’s Disease Was Kept Relative Stable with Sequential Therapy for Eight Years. World Journal of Neuroscience, 7, 209-215. doi: 10.4236/wjns.2017.72016.