Author(s)

Daisuke Matsuzawa, Kotaro Takeda, Hiroyuki Ohtsuka, Jun Takasugi, Takashi Watanabe, Junko Maeda, Saeka Nagakubo, Chihiro Sutoh, Ichiro Shimoyama, Ken Nakazawa, Eiji Shimizu

Clinical Research Center, National Hospital Organization Murayama Medical Center, Tokyo, Japan.
Department of Cognitive Behavior Physiology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Section for Human Neurophysiology, Frontier Medical Engineering, Chiba University, Chiba, Japan.

Depression has been known to reduce the prefrontal activity associated with the execution of certain cognitive tasks, although whether a temporarily depressed or anxious mood in healthy individuals affects the prefrontal blood oxygen level during cognitive tasks is unknown. Combining the measurement of prefrontal activity with near-infrared spectroscopy (NIRS) and the two cognitive tasks, namely the letter version of the verbal fluency test (VFT-l) and the Stroop test, we measured the effect of a depressed or anxious mood and gender on the changes in the prefrontal oxygenated hemoglobin (Oxy-Hb) levels during those cognitive tests in healthy individuals. Depressed mood or anxious mood was assessed by the Hospital Anxiety and Depression Scale (HADS). Thereby we aimed to explore the possibility of NIRS measurement for detecting the early subclinical manifestation of major depression. Moreover, we examined the possible relationships between prefrontal activation and the functional Val66Met polymorphisms of the brain derived neurotropic factor (BDNF) gene and serum BDNF level. As a result, the increased prefrontal Oxy-Hb levels during cognitive tasks were significantly correlated with the severity of depressed mood in males. The course of the prefrontal Oxy-Hb increase was different depending on the cognitive tasks, i.e., the VFT-l or the Stroop test, in both genders. Correlations of BDNF genotype and serum BDNF level with the prefrontal Oxy-Hb levels during those cognitive tasks were negative. Our results suggest that the early subclinical manifestation of depressed mood in males might be detected by the NIRS measurement, which is not correlated with the individual properties of BDNF.

Near-Infrared Spectroscopy (NIRS); Depression; Anxiety; Brain Derived Neurotropic Factor (BDNF)

Matsuzawa, D. , Takeda, K. , Ohtsuka, H. , Takasugi, J. , Watanabe, T. , Maeda, J. , Nagakubo, S. , Sutoh, C. , Shimoyama, I. , Nakazawa, K. and Shimizu, E. (2012) Correlation of prefrontal activity measured by near-infrared spectroscopy (NIRS) with mood, BDNF genotype and serum BDNF level in healthy individuals. Open Journal of Psychiatry, 2, 194-203. doi: 10.4236/ojpsych.2012.23025.