IJCM> Vol.2 No.1, February 2011

Acupuncture for the Treatment of Hot Flashes in Men with Advanced Prostate Cancer

ABSTRACT

PURPOSE: To test the safety and efficacy of acupuncture in reducing hot flashes in men with advanced prostate cancer (CaP) undergoing androgen deprivation therapy. METHODS: A single-arm, pilot study was undertaken to evaluate acupuncture treatment for hot flashes experienced by CaP patients undergoing hormonal therapy. Sixteen advanced CaP patients undergoing androgen deprivation therapy (ADT) received standardized full body and auricular acupunc-ture 1x/week for 14 weeks. Patients were evaluated at 0, 7, 14, and an additional 14-wk follow-up (F/U) (28-wks). Safety was measured by monitoring for adverse events over the treatment period. Serum testosterone was measured at 0 and 14-wks. Quality of life (QOL) was measured by the hormone domain of the Expanded Prostate Index Composite (EPIC), at the 0, 7, 14, and 28-wks and patient reported hot flash frequency was assessed weekly. Safety endpoints were serum testosterone and analysis of adverse events. Efficacy endpoints were scores on the EPIC and the number of pa-tient reported hot flashes. RESULTS: 17 patients were enrolled and 15 completed the trial. Of 15 evaluable patients the median age was 68 ± 8.19. Serum analysis demonstrated no change in testosterone at baseline 9.5 ng/ml ± 8.9 vs. end-point 14 ± 8.78 (p = 0.101). No adverse events were reported. Data analysis of the EPIC demonstrated a trend toward improvement after 7 wks and a significant improvement following 14 wks of acupuncture (p = 0.01). Analysis of patient reported frequency showed a significant reduction in the number of hot flashes at 7-wk (6, p = 0.04), 14-wk (2.6, p = 0.001), and 28-wk F/U (3.2, p = 0.01) as compared to baseline 9.57 ± 3.98. CONCLUSIONS: The administration of acupuncture in men with advanced CaP appears to significantly decrease the frequency of hot flashes. No serious ad-verse events were noted and serum testosterone levels were unchanged from baseline suggesting that the mechanism of action of acupuncture for hot flash amelioration is not via increase in testosterone.

KEYWORDS


Cite this paper

J. Capodice, P. Cheetham, M. Benson, J. McKiernan and A. Katz, "Acupuncture for the Treatment of Hot Flashes in Men with Advanced Prostate Cancer," International Journal of Clinical Medicine, Vol. 2 No. 1, 2011, pp. 51-55. doi: 10.4236/ijcm.2011.21010.

References

[1] A. Jemal, R. Siegel, E. Ward, Y. Hao, J. Xu and M. J. Thun, “Cancer Statistics,” CA: A Cancer Journal of Clinsician, Vol. 59, No. 4, 2009, pp. 225-229.
[2] M. B. Garnick, “Prostate Cancer: Screening, Diagnosis, and Management,” Annals of Internal Medicine, Vol. 118, No. 10, 1993, pp. 804-818.
[3] C. S. Higano, “Side Effects of Androgen Deprivation Therapy: Monitoring and Minimizing Toxicity,” Urology, Vol. 61, No. 2, Suppl. 1, 2003, pp. 32-38. doi:10.1016/S0090-4295(02)02397-X
[4] J. Anderson, “The Role of Antiandrogen Monotherapy in the Treatment of Prostate Cancer,” British Journal of Urology International, Vol. 91, No. 5, 2003, pp. 455-461.
[5] K. Suzuki, M. Kobayashi and A. Tokue, “Clinical Evaluation of Hot Flushes Developing during Endocrine Therapy for Prostate Carcinoma,” Nippon Hinyokika Gakkai Zasshi, Vol. 94, No. 6, 2003, pp. 614-620.
[6] H. MacPherson, A. White, M. Cummings, K. Jobst, K. Rose and R. Niemtzow, “Standards for Reporting Interventions in Controlled Trials of Acupuncture: The STRICTA Recommendations,” Complementary Therapies in Medicine, Vol. 9, No. 4, 2001, pp. 246-249. doi:10.1054/ctim.2001.0488
[7] M. Hammar, J. Frisk, O. Grimas, et al., “Acupuncture Treatment of Vasomotor Symptoms in Men with Prostatic Carcinoma: A Pilot Study,” Journal of Urology, Vol. 161, 1999, pp. 853-856. doi:10.1016/S0022-5347(01)61789-0
[8] X. Chen, “Chinese Acupuncture and Moxibustion,” Foreign Languages Press, Beijing, 1999.
[9] Y. Wu and W. Fisher, “Practical Therapeutics of Traditional Chinese Medicine,” Paradigm Publications, Brookline, 1997.
[10] A. U. Asghar, G. Green, M. F. Lythgoe, G. Lewith and H. MacPherson, “Acupuncture Needling Sensation: The Neural Correlates of DEQI Using fMRI,” Brain Research, Vol. 1315, 2010, pp. 111-118. doi:10.1016/j.brainres.2009.12.019
[11] E. Manheimer, K. Linde, L. Lao, L. M. Bouter and B. M. Berman, “Meta-Analysis: Acupuncture for Osteoarthritis of the Knee,” Annals of Internal Medicine, Vol. 146, No. 12, 2007, pp. 868-867.
[12] L. J. Hanisch, S. C. Palmer, S. C. Marcus, L. Hantsoo, D. J. Vaughn and J. C. Coyne, “Comparison of Objective and Patient-Reported Hot Flash Measures in Men with Prostate Cancer,” Journal of Supportive Oncology, Vol. 7, No. 4, 2009 pp. 131-135.
[13] C. Harding, A. Harris and D. Chadwick, “Auricular Acupuncture: A Novel Treatment for Vasomotor Symptoms Associated with Luteinizing-Hormone Releasing Hormone agonist Treatment for Prostate Cancer,” British Journal of Urology International, Vol. 103, No. 2, 2009, pp. 186-190.
[14] C. L. Loprinzi, A. C. Dueck, B. S. Khoyratty, D. L. Barton, S. Jafar, K. M. Rowland Jr, P. J. Atherton, G. W. Marsa, W. H. Knutson, J. D. Bearden 3rd, L. Kottschade and T. R. Fitch, “A Phase III Randomized, Double-Blind, Placebo-Controlled Trial of Gabapentin in the Management of Hot Flashes in Men (N00CB),” Annals of Oncology, Vol. 20, No. 3, 2009, pp. 542-549. doi:10.1093/annonc/mdn644
[15] E. M. Walker, A. I. Rodriguez, B. Kohn, R. M. Ball, J. Pegg, J. R. Pocock, R. Nunez, E. Peterson, S. Jakary and R. A. Levine, “Acupuncture versus Venlafaxine for the Management of Vasomotor Symptoms in Patients with Hormone Receptor-Positive Breast Cancer: A Randomized Controlled Trial,” Journal of Clinical Oncology, Vol. 28, No. 4, 2010, pp. 634-640. doi:10.1200/JCO.2009.23.5150
[16] A. Moazzami, S. C. Tjen-A-Looi, Z. L. Guo and J. C. Longhurst, “Serotonergic Projection from Nucleus Raphe Pallidus to Rostral Ventrolateral Medulla Modulates Cardiovascular Reflex Responses during Acupuncture,” Journal of Applied Physiology, 2010 Feb 4.
[17] L. Bai, H. Yan, Li L, W. Qin, P. Chen, P. Liu, Q. Gong, Y. Liu and J. Tian, “Neural Specificity Of Acupuncture Stimulation at Pericardium 6: Evidence from an FMRI Study,” Journal of Magnetic Resonance Imaging, Vol. 31, No. 1, 2010, pp. 71-77. doi:10.1002/jmri.22006

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