Dissociation between Performances in Water Maze and Spontaneous Alternation in BALB/C versus A/J Mice

Julien Celestine, Arnaud Tanti, Arnaud Aubert

EA 2114, Psychologie des Ages de la Vie, Université de Tours, 3 rue des Tanneurs, 37041 Tours Cedex 1, France.
Faculté des Sciences et Techniques, Université Fran?ois Rabelais, Tours, France.
INSERM U930 E2 Neurogénétique et Neurométabolomique CHRU de Tours, Hopital Bretonneau, 2 Boulevard Tonnellé, Bat B1A, 1er Etage, 37044 Tours Cedex 9, France.

DOI: 10.4236/jbbs.2012.22018                

Abstract

Learning processes are extensively studied in behavioral neuroscience. As experimental models, Morris Water Maze (MWM) and Spontaneous Alternation (SA) represent two of the most frequently used laboratory tests to respectively address spatial vs non-spatial tasks. Several factors have been shown to impact on those learning, including strain, gender, apparatus, conditioning, vision, lighting conditions and stress level. In order to focus on the later, we compared the acquisition of two learning tasks (MWM and SA) in BALB/c and A/J mice, which are known as fearful and stress-sensitive strains. Here, we report that BALB/c mice exhibited higher performances than A/J mice in the MWM (i.e. spatial reference memory task), whereas A/J mice performed better in the SA (i.e. spatial working memory task). These results indicate dissociated processes in the acquisition of spatial vs non-spatial tasks, and emphasize a varying influence of emotional reactivity on different forms of cognition.

Keywords

Morris Water Maze; Spontaneous Alternation; Behavior; BALB/c; A/J; Learning

Conflicts of Interest

The authors declare no conflicts of interest.

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