Share This Article:

The effect of L-ornithine hydrochloride ingestion on human growth hormone secretion after strength training

Full-Text HTML Download Download as PDF (Size:210KB) PP. 7-11
DOI: 10.4236/abb.2010.11002    5,921 Downloads   14,780 Views   Citations

ABSTRACT

This study aimed to examine the effect of L-ornithine hydrochloride ingestion on serum growth hormone secretion response after strength training in young men who did not regularly engage in high intensity exercise. Ten healthy young males without workout habits (age: 22.2 +/- 1.0 yr). Subjects performed biceps curl strength training after L-ornithine hydro- chloride and placebo ingestions. They participated in both of the above conditions randomly with a week interval in between. Serum growth hormone and ornithine levels were measured before L-ornithine hydrochloride or placebo ingestions and at 30 minutes after strength training. Serum growth hormone and ornithine level were measured. A change magnitude of serum growth hormone was significantly larger in the L-ornithine hydrochloride condition than in the placebo condition, and the effect size was also large (t = 1.91, p = .044, ES = .75). A significant interaction (F = 280.98, p = 0.000, ηp2 = 0.96) was found in serum ornithine and a multiple comparison test showed that it was greater in the L-ornithine hydrochloride condition. Serum growth hormone level after strength training increases by L-ornithine hydrochloride ingestion in untrained young males.

Cite this paper

Demura, S. , Yamada, T. , Yamaji, S. , Komatsu, M. and Morishita, K. (2010) The effect of L-ornithine hydrochloride ingestion on human growth hormone secretion after strength training. Advances in Bioscience and Biotechnology, 1, 7-11. doi: 10.4236/abb.2010.11002.

References

[1] Knopf, R.F., Conn, J.W., Fajans, S.S., Floyd, J.C., Guntsche, E.M. and Rull, J.A. (1965) Plasma groeth hormone response to intravenous administration of amino acids. The Journal of Clinical Endocrinology and Metabolism, 25, 1140-1144.
[2] Evain-Brion, D., Donnadieu, M., Roger, M. and Job, J.C. (1982) Simultaneous study of somatotrophic and corticotrophic pituitary secretions during ornithine infusion test. Clinical Endocrinology, 1982, 17, 119-122.
[3] Chromiak, J.A. and Antonio, J. (2002) Use of amino acids as growth hormone-releasing agents by athletes. Nutrition, 18, 657-661.
[4] Carlson, H.E., Miglietta, J.T., Roginsky, M.S. and Stegink, L.D. (1989) Stimulation of pituitary hormone secretion by neurotransmitter amino acids in humans. Metabolism, 38, 1179-1182.
[5] Lambert, M.I., Hefer, J.A., Millar, R.P. and Macfarlane, P.W. (1993) Failure of commercial oral amino acid supplements to increase serum growth hormone concentrations in male body-builders. International Journal of Sport Nutrition, 3, 298-305.
[6] Fogelholm, G.M., Näveri, H.K., Kiilavuori, K.T. and Härkönen, M.H. (1993) Low-dose amino acid supplementation: no effects on serum human growth hormone and insulin in male weightlifters. International Journal of Sport Nutrition, 3, 290-297.
[7] Fry, A.C., Kraemer, W.J., Stone, M.H., Warren, B.J., Kearney, J.T., Maresh, C.M., Weseman, C.A. and Fleck SJ. (1993) Endocrine and performance responses to high volume training and amino acid supplementation in elite junior weightlifters. International Journal of Sport Nutrition, 3, 306-322.
[8] Cynober, L. (2007) Pharmacokinetics of arginine and related amino acids. Journal of Nutrition, 137, 1646-1649.
[9] Cynober, L., Coudray-Lucas, C., de Bandt, J.P., Guéchot, J., Aussel, C., Salvucci, M. and Giboudeau, J. (1990) Action of ornithine alpha-ketoglutarate, ornithine hydrochloride, and calcium alpha-ketoglutarate on plasma amino acid and hormonal patterns in healthy subjects. Journal of the American College of Nutrition, 9, 2-12.
[10] Bucci, L., Hickson, J.F., Pivarnik, J.M., Wolinsky, I., Mc Mahon, J.C. and Turner, S.D. (1990) Ornithine ingestion and growth hormone release in bodybuilders. Nutrition Research, 10, 239-245.
[11] Ball, N. and Scurr, J. (2010) An assessment of the reliability and standardisation of tests used to elicit reference muscular actions for electromyographical normalisation. Journal of Electromyography and Kinesiology, 20, 81-88.
[12] Earle, R.W. (1999) Weight training exercise prescription. Essentials of Personal Training Symposium Workbook. SCA Certification Commission, Lincoln.
[13] Hansen, S., Kvorning, T., Kjaer, M. and Sjøgaard, G. (2001) The effect of short-term strength training on human skeletal muscle: the importance of physiologically elevated hormone levels. Scandinavian Journal of Medicine & Science in Sports, 11, 347-354.
[14] Chesley, A., MacDougall, J.D., Tarnopolsky, M.A., Atkinson, S.A. and Smith, K. (1992) Changes in human muscle protein synthesis after resistance exercise. Journal of Applied Physiology, 73, 1383-1388.
[15] White, T.P. and Esser, K.A. (1989) Satellite cell and growth factor involvement in skeletal muscle growth. Medicine and Science in Sports and Exercise, 21, 158-163.
[16] Collier, S.R., Casey, D.P. and Kanaley, J.A. (2005) Growth hormone responses to varying doses of oral arginine. Growth Hormone & IGF Research, 15, 136-139.

  
comments powered by Disqus

Copyright © 2017 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.