Primary Embryonal Lung Carcinoma and Testicular Seminoma in the Same Patient Ten-Years Later: Case-Report and Literature Review

Abstract

Primary germ cell tumors of lung are extremely rare. The prognosis is usually poor, with various symptoms seriously affecting quality of life. In this paper we describe the unique case of a patient affected by an embryonal carcinoma of lung and a testicular seminoma after ten years. We also report literature about pulmonary extragonadal germ cell tumors.

Share and Cite:

P. Rescigno, G. Di Lorenzo, L. Raimondo, C. D’Aniello, E. Matano, V. Damiano, L. Nappi, L. Puglia, A. Petremolo, P. Federico and G. Palmieri, "Primary Embryonal Lung Carcinoma and Testicular Seminoma in the Same Patient Ten-Years Later: Case-Report and Literature Review," Open Journal of Urology, Vol. 2 No. 2, 2012, pp. 83-86. doi: 10.4236/oju.2012.22016.

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1] C. Bokemeyer and C. R. Nichols, “Extragonadal Germ Cell Tumors of the Mediastinum and Retroperitoneum: Results from an International Analysis,” Journal of Clinical Oncology, Vol. 20, No. 7, 2002, pp. 1864-1873. doi:10.1200/JCO.2002.07.062
[2] J. K. McKenney and A. Heerema-McKenney, “Extragonadal Germ Cell Tumors: A Review with Emphasis on Pathologic Features, Clinical Prognostic Variables, and Differential Diagnostic Considerations,” Advances in Anatomic Pathology, Vol. 14, No. 2, 2007, pp. 69-92. doi:10.1097/PAP.0b013e31803240e6
[3] A. Basoglu and A. T. Sengul, “Pure Yolk-Sac Tumor of the Lung,” Asian Cardiovascular and Thoracic Annals, Vol. 16, No. 5, 2008, pp. 410-411.
[4] H. Inoue and M. Iwasaki, “Pure Yolk-Sac Tumor of the Lung,” Thoracic and Cardiovascular Surgery, Vol. 41, No. 4, 1993, pp. 249-251. doi:10.1055/s-2007-1013864
[5] N. Kakkar and R. K. Vasishta, “Primary Pulmonary Malignant Teratoma with Yolk Sac Element Associated with Hematologic Neoplasia,” Respiration, Vol. 63, No. 1, 1996, pp. 52-54. doi:10.1159/000196516
[6] G. Pelosi and F. Petrella, “A Primary Pure Yolk Sac Tumor of the Lung Exhibiting CDX-2 Immunoreactivity and increased Serum Levels of Alkaline Phosphatase Intestinal Isoenzyme,” International Journal of Surgical Pathology, Vol. 14, No. 3, 2006, pp. 247-251. doi:10.1177/1066896906290657
[7] Y. Umemori and A. Hiraki, “Primary Choriocarcinoma of the Lung,” Anticancer Research, Vol. 24, No. 3B, 2004, pp. 1905-1910.
[8] P. Vaideeswar and J. Mehta, “Primary Pulmonary Choriocarcinom—A Series of 7 Cases,” Indian Journal of Pathology and Microbiology, Vol. 47, No. 4, 2004, pp. 494-496.
[9] H. Arabi and M. Shah, “Aspiration Biopsy Cytomorphology of Primary Pulmonary Germ Cell Tumor Metastatic to the Brain,” Diagnostic Cytopathology, Vol. 37, No. 10, 2009, pp. 715-719. doi:10.1002/dc.21089
[10] I. Maestá and F. V. Leite, “Primary Pulmonary Choriocarcinoma after Human Chorionic Gonadotropin Normalization Following Hydatidiform Mole: A Report of Two Cases,” Journal of Reproductive Medicine, Vol. 55, No. 7-8, 2010, pp. 311-316.
[11] H. Adachi and T. Aki, “Combined Choriocarcinoma and Adenocarcinoma of the Lung,” Acta Pathologica Japonica, Vol. 39, No. 2, 1989, pp. 147-152.
[12] S. Yamamoto and H. Tanaka, “Primary Pulmonary Choriocarcinoma Combined with Adenocarcinoma,” Pathology International, Vol. 56, No. 7, 2006, pp. 402-407. doi:10.1111/j.1440-1827.2006.01977.x
[13] F. Chen and A. Tatsumi, “Combined Choriocarcinoma and Adenocarcinoma of the Lung Occurring in a Man: Case Report and Review of the Literature,” Cancer, Vol. 91, No. 1, 2001, pp. 123-129. doi:10.1002/1097-0142(20010101)91:1<123::AID-CNCR16>3.0.CO;2-3
[14] B. Coulier and Y. Lefebvre, “Metastases of Clinically Occult Testicular Seminoma Mimicking Primary Extragonadal Retroperitoneal Germ Cell Tumors,” Journal Belge de Radiologie, Vol. 91, No. 4, 2008, pp. 139-144.
[15] J. C. Angulo and J. González, “Clinicopathological Study of Regressed Testicular Tumors (Apparent Extragonadal Germ Cell Neoplasms),” Journal of Urology, Vol. 182, No. 5, 2009, pp. 2303-2310. doi:10.1016/j.juro.2009.07.045
[16] A. B. Shinagare and J. P. Jagannathan, “Adult Extragonadal Germ Cell Tumors,” American Journal of Roentgenology, Vol. 195, No. 4, 2010, pp. 274-280.
[17] R. G. Levitt and J. E. Husband, “CT of Primary GermCell Tumors of the Mediastinum,” American Journal of Roentgenology, Vol. 142, No. 1, 1984, pp. 73-78.
[18] J. C. Cheville and S. Rao, “Cytokeratin Expression in Seminoma of the Human Testis,” American Journal of Clinical Pathology, Vol. 113, No. 4, 2000, pp. 583-588.

Copyright © 2024 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.