Oxidized phospholipids modify plasminogen and apolipoprotein(a): Implications for vascular disease

Angelo M. Scanu, Diana M. Stafforini, Celina Edelstein

Department of Medicine, University of Chicago, Chicago, USA.
Department of Medicine, University of Chicago, Chicago, USA; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, USA.
Huntsman Cancer Institute, University of Utah, Salt Lake City, USA.

DOI: 10.4236/ajmb.2012.22012                

Abstract

Whereas the close structural homology between human plasminogen and apolipoprotein(a) has been known for a number of years only recent studies have revealed that both proteins carry linked oxidized phospholipids that may modify the function of these proteins. Future studies should provide a better understanding of oxidized phospholipid adducts and the role played by lipoprotein-associated phospholipase A₂ for which cleavage specificity has been established when these modified lipids are in a free form.

Keywords

Plasminogen; Apolipoprotein(a); Lipoprotein(a); Oxidized Phospholipids; Oxidized Phosphatidylcholines

Conflicts of Interest

The authors declare no conflicts of interest.

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