基本情况
程义云
华东师范大学生命科学学院，教授、博士生导师
yycheng@mail.ustc.edu.cn
个人经历
教育及工作经历:
2010年至今: 华东师范大学, 生命科学学院, 教授, 博士生导师；
2009年: 圣路易斯华盛顿大学, 生物医学工程系(夏幼南教授), 博士后研究助理;
2004-2008年: 中国科学技术大学, 生命科学学院(施蕴渝院士), 获得结构生物学博士学位;
2000-2004年: 中国科学技术大学, 高分子科学与工程系(徐铜文教授), 获得理学学士学位。
国际刊物、出版物编辑 (Editors):
2010年至今: Current Drug Discovery Technologies (Regional Editor);
2010年: 应著名出版公司John Wiley & Sons, Inc.邀请担任“Dendrimer-based Drug Delivery Systems: From Theory to Practice”一书的主编 (Editor-in chief)。
国际刊物编委 (Editorial Board Members):
2009年至今: Open Journal of Pharmacology;
2008年至今: Local and Regional Anesthesia;
2009-2010年: Current Drug Discovery Technologies;
2009年至今: Der Pharma Chemica.
研究方向:
纳米医药, 生物材料;
研究兴趣:
* 树枝形分子等纳米材料的合成及其在生物医学中的应用研究;
* 基于树枝形分子的主-客体系统的设计及其在药物运输中的应用;
* 生物兼容的纳米材料在早期肿瘤诊断及治疗中的应用研究；
* 将多维核磁等技术应用于纳米药物剂型设计及优化的研究。
国际刊物审稿人 (Invited Reviewers):
Journal of Physical Chemistry B, Journal of Controlled Release, Biomacromolecules, Langmuir, European Journal of Medicinal Chemistry, Current Drug Delivery, International Journal of Pharmaceutics, Acta Biomaterialia, Bioorganic& Medicinal Chemistry Letters, Bioorganic& Medicinal Chemistry，Nanomedicine, Pharmacological Research, Drug Development and Industrial Pharmacy, Spectroscopy Letters, Colloids and Surface B, Journal of Macromolecular Sciences, Expert Opinion on Drug Metabolism and Toxicology, Letters in Organic Chemistry, Current Nanosciences, Current Drug Discovery Technologies, Open Journal of Pharmacology, International Journal of Nanomedicine, Journal of Composite Materials, Environmental Research, Letters in Drug Design and Discovery, Water Environmental Research, Frontiers of Chemical Engineering in China, Chemical Papers, Scientific Research and Assays, Materials, Journal of Nano Research.
邀请综述 (Invited Reviews):
Chemical Society Reviews, Soft Matter, Journal of Pharmaceutical Sciences, Frontiers in Biosciences, European Journal of Medicinal Chemistry, Combinatorial Chemistry & High Throughput Screening, Current Drug Discovery Technologies, etc.
出版书籍/章节 (Book Chapters):
Cheng YY, Chen DZ, Xu TW* and He PS*. The Cure Behavior of Thermosetting Resin Based Nanocomposites Characterized by Using Dynamic Torsional Vibration Method. Chapter 10, in “Recent Advances in Polymer Nanocomposites”, Edited by Prof. Sabu Thomas, Nova Science Publishers Inc., USA, NY 11788, 2009.
近期发表论文 (Selected Publications):
近5年发表树枝形分子药物运输系统相关的SCI学术论文40篇, 其中第一/通讯作者论文34篇, 影响因子总和 (2009年) 超过160, 其中7篇 (次) 论文为发表当年/季度该杂志最热门文章或引用次数最多的论文(most frequently downloaded/hottest articles), 2篇论文被多家杂志, 媒体或网站Highlight, 论文被他人公开引用550多次 (*通讯作者):
1) Yavuz MS†, Cheng YY†, Chen JY†, Cobley CM, Zhang Q, Rycenga M, Xie JW, Kim C, Schwartz AG, Wang LV, Xia YN*. Gold Nanocages Covered by Smart Polymers for Controlled Release with Near-infrared Light. Nature Materials, 2009, 8(12), 935-939. (†共同第一作者; 2009年影响因子29.504; 他引43次; 论文自发表以来被 Science Daily, The New York Times, R & D Magazines, Nanomedicine, Science Centric, Medical News Today, Pharmaceutical Formulation & Quality, Physics News 等多家权威媒体, 杂志转载报导).
2) Cheng YY*, Zhao LB, Li YW, Xu TW*. Design of Biocompatible Dendrimers for Cancer Diagnosis and Therapy: Current Status and Future Perspectives, Chemical Society Reviews, 2010, doi: 10.1039/C0CS00097C, in press. (2009年影响因子20.06).
3) Zhao LB, Wu QL, Cheng YY*, Zhang JH, Wu JH, Xu TW*. High-Throughput Screening of Dendrimer-Binding Drugs, Journal of the American Chemical Society, 2010, 132(38), 13182-13184. (2009年影响因子8.58).
4) Cheng YY*, Xu ZH, Ma ML, Xu TW*. Dendrimers as Drug Carriers: Applications in Different Routes of Drug Administration. Journal of Pharmaceutical Sciences, 2008, 97(1):123-143. (2008年被选为该杂志10篇最热门的文章之一; 2009年再次被选为该杂志年度引用次数最多的论文; 论文他引61次).
5) Cheng YY*, Wu QL, Li YW, and Xu TW*, External Electrostatic Interaction versus Internal Encapsulation between Cationic Dendrimers and Negatively Charged Drugs: Which Contributes More to Solubility Enhancement of the Drugs? Journal of Physical Chemistry B, 2008, 112:8884-8890. (2009年影响因子3.471; 论文他引13次).
6) Hu JJ, Cheng YY*, Wu QL, Zhao LB, Xu TW*, Host-Guest Chemistry of Dendrimer-Drug Complexes: 2. Effects of Molecular Properties of Guests and Surface Functionalities of Dendrimers, Journal of Physical Chemistry B, 2009, 113(31): 10650-10659. (2009年影响因子3.471; 论文他引5次).
7) Zhao LB, Cheng YY*, Hu JJ, Wu QL, Xu TW*, Host-Guest Chemistry of Dendrimer-Drug Complexes: 3. Competitive Binding of Multi-drugs to a Single Dendrimer, Journal of Physical Chemistry B, 2009, 113(43): 14172-14179. (2009年影响因子3.471; 论文他引4次).
8) Cheng YY*, Li YW, Wu QL, Xu TW*, New Insights into the Interactions between Dendrimers and Surfactants by Two Dimensional NOE NMR Spectroscopy, Journal of Physical Chemistry B, 2008, 112(40): 12674-12680. (2009年影响因子3.471; 论文他引8次).
9) Hu JJ, Cheng YY*, Ma YR, Wu QL, Xu TW*, Host-Guest Chemistry and Physico-chemical Properties of Dendrimer-Mycophenolic Acid Complexes, Journal of Physical Chemistry B, 2009, 113(1):64-74. (2009年影响因子3.471).
10) Cheng YY*, Wu QL, Li YW, Hu JJ, Xu TW*, New Insights into the Interactions between Dendrimers and Surfactants: 2. Design of New Drug Formulations Based on Dendrimer-Surfactant Aggregates, Journal of Physical Chemistry B, 2009, 113(24), 8339-8346. (2009年影响因子3.471).
11) Wu QL, Cheng YY*, Hu JJ, Zhao LB, Xu TW*, New Insights into the Interactions between Dendrimers and Surfactants: 3. Size- and Hydrophobicity-Dependent Encapsulation of Bile Salts, Journal of Physical Chemistry B, 2009, 113, 12934-12943. (2009年影响因子3.471).
12) Fang M, Cheng YY*, Zhang JH, Wu QL, Hu JJ, Zhao LB, Xu TW*, New Insights into the Interactions between Dendrimers and Surfactants: 4. Fast Exchange/Slow Exchange Transitions in the Structure of Dendrimer-Surfactant Aggregates, Journal of Physical Chemistry B, 2010, 114(18):6048-6055. (2009年影响因子3.471).
13) Yang K, Cheng YY*, Feng XY, Zhang JH, Wu QL, Xu TW*, New Insights into the Interactions between Dendrimers and Mixed Micelles: 5. Formation of Miscellaneous Mixed Micelles Revealed by a Combination of 1H NMR, Diffusion, and NOE Analysis, Journal of Physical Chemistry B, 2010, 114(21): 7265-7273. (2009年影响因子3.471).
14) Feng XY, Cheng YY*, Yang K, Zhang J, Wu Q, Xu TW*. Host-Guest Chemistry of Dendrimer-Drug Complexes, 5. Insights into the Design of Formulations for Noninvasive Delivery of Heparin Revealed by Isothermal Titration Calorimetry and NMR Studies, Journal of Physical Chemistry B, 2010, 114 (34), 11017-11026. (2009年影响因子3.471).
15) Hu JJ, Fang M, Cheng YY*, Zhang JH, Wu QL, Xu TW*, Host-Guest Chemistry of Dendrimer-Drug Complexes: 4. An In-depth Look into the Binding/Encapsulation of Guanosine Monophosphate by Dendrimers, Journal of Physical Chemistry B, 2010, 114(21):7148-7157. (2009年影响因子3.471).
16) Cheng YY, Wang JR, Rao TL, He XX, Xu TW*. Pharmaceutical Applications of Dendrimers: Promising Nanocarriers for Drug Delivery. Frontiers in Bioscience, 2008, 13: 1447-1471. (2009年影响因子3.736; 论文他引35次).
17) Yang WJ, Li YW, Cheng YY*, Wu QL, Wen LP, Xu TW*, Evaluation of Phenylbutazone and Poly(amidoamine) Dendrimers Interactions by a Combination of Solubility, 2D-NOESY NMR, and Isothermal Titration Calorimetry Studies, Journal of Pharmaceutical Sciences, 2009, 98(3), 1075-1085.
18) Cheng YY*†, Li YW†, Wu QL, Zhang JH, Xu TW*, Generation-Dependent Encapsulation/Electrostatic Attachment of Phenobarbital Molecules by Poly(amidoamine) Dendrimers: Evidence from 2D-NOESY Investigations, European Journal of Medicinal Chemistry, 2009, 44(5):2219-2213. (†共同第一作者兼通讯作者; 2009年影响因子3.269).
19) Yang WJ, Cheng YY*, Xu TW*, Wang XY, Wen LP*, Targeting Cancer Cells with Dendrimer-Biotin Conjugates, European Journal of Medicinal Chemistry, 2009, 44(2): 862-868. (European Journal of Medicinal Chemistry 2009年4-6月Top 25 热门的文章; 2009年影响因子3.269; 论文他引30次).
20) Cheng YY*†, Gao Y†, Rao TL, Li YW, Xu TW*, Dendrimers-Based Prodrugs: Design, Synthesis and Biological Evaluation, Combinatorial Chemistry & High Throughput Screening, 2007, 10(5): 336-349. (†共同第一作者兼通讯作者; 论文他引15次).
21) Cheng YY*, Man N, Xu TW, Fu RQ, Wang XY, Wang XM, Wen LP*, Transdermal Delivery of Non-Steroidal Anti-Inflammatory Drugs Mediated by Polyamidoamine (PAMAM) Dendrimers. Journal of Pharmaceutical Sciences, 2007, 96(3):595-602. (被“Topical Drug Delivery and Nanotechnology”作为一种有前景的临床给药方法报导; 论文他引39次).
22) Cheng YY*, Xu TW*, The Effect of Dendrimers on the Pharmacodynamic and Pharmacokinetic behaviors of Non-covalently or Covalently Attached Drugs, European Journal of Medicinal Chemistry, 2008, 43: 2291-2297. (European Journal of Medicinal Chemistry 2008年10-12月Top 25 热门的文章排名第二; 2009年影响因子3.269; 论文他引31次).
23) Cheng YY*, Li MZ, Xu TW*, Potential of Poly(amidoamine) Dendrimers as Drug Carriers of Camptothecin Based on Encapsulation Studies, European Journal of Medicinal Chemistry, 2008, 43:1791-1795. (2009年影响因子3.269).
24) Cheng YY*, Qu HO, Ma ML, Xu ZH, Xu P, Fang YJ, Xu TW*. Polyamidoamine (PAMAM) Dendrimers as Biocompatible Carriers of Quinolone Antimicrobials: An In Vitro Study. European Journal of Medicinal Chemistry, 2007, 42: 1032-1038. (2009年影响因子3.269; 论文他引24次).
25) Ma ML, Cheng YY*, Xu ZH, Xu P, Qu HO, Fang YJ, Xu TW, Wen LP*. Evaluation of Polyamidoamine (PAMAM) Dendrimers as Drug Carriers of Anti-Bacterial Drugs Using Sulfamethoxazole (SMZ) as a Model Drug. European Journal of Medicinal Chemistry, 2007, 42:93-98. (2009年影响因子3.269; 论文他引27次).
26) Li YW, Cheng YY*, Xu TW*. Design, Synthesis and Potent Pharmaceutical Applications of Glycodendrimers: A Mini-review”. Current Drug Discovery Technologies, 2007, 4(4), 246-254. (论文他引19次).
27) Man N†, Cheng YY†, Xu TW, Ding Y, Li ZW, Huang GY, Shi YY*, Wen LP*. Dendrimers as Potential Drug Carriers. Part II. Prolonged Delivery of Ketoprofen by In Vitro and In Vivo Studies. European Journal of Medicinal Chemistry, 2006, 41(5): 670-674. (†共同第一作者; European Journal of Medicinal Chemistry 2006年4-12月连续3个季度入选为Top 25 热门文章; 论文他引35次; 2009年影响因子3.269).
28) Cheng YY*, Xu TW. Dendrimers as Potential Drug Carriers. Part I. Solubilization of Non-Steroidal Anti-Inflammatory Drugs in the Presence of Polyamidoamine Dendrimers. European Journal of Medicinal Chemistry, 2005, 40 (11): 1188-1192. (European Journal of Medicinal Chemistry 2005年10-12月Top 25 热门文章排名第4; 论文他引51次; 2009年影响因子3.269).
29) Cheng YY*, Xu TW, Fu RQ. Polyamidoamine Dendrimers Used as Solubility Enhancers of Ketoprofen. European Journal of Medicinal Chemistry, 2005, 40(12): 1390-1393. (论文他引34次; 2009年影响因子3.269).
30) Cheng YY*, Xu TW. Solubility of Nicotinic Acid in Polyamidoamine Dendrimer Solutions. European Journal of Medicinal Chemistry, 2005, 40 (12): 1384-1389. (论文他引17次; 2009年影响因子3.269).
31) Cheng YY*, Yang JP. Solubilization of Non-steroidal Anti-inflammatory Drugs in the Presence of Tween Series Surfactants, Physics and Chemistry of Liquids, 2006, 44 (3): 249-256. (2006年度被选为该杂志最热门的10篇文章之一, 排名第五).
32) Cheng YY, Yang JP*. Effect of Polyamidoamine Dendrimers in Decolorising Triarylmethane Dye Effluent, Coloration Technology, 2005, 121, 72-75.
33) Cheng YY, Chen DZ, Fu RQ, He PS*. Behavior of Polyamidoamine Dendrimers as Curing Agents in Bis-phenol A Epoxy Resin Systems. Polymer International, 2005, 54:495-499.
34) Cheng YY, Xu TW*, He PS. Polyamidoamine (PAMAM) Dendrimers as Curing Agents: The Optimum PAMAM Concentration Selected by Dynamic Torsional Vibration Method and Thermogravimetric Analyses. Journal of Applied Polymer Science, 2007, 103: 1430-1434.
35) Fu RQ, Xu TW*, Cheng YY, Yang WH, Pan ZX. Fundamental Studies on the Intermediate Layer of a Bipolar Membrane Part III. Effect of Starburst Dendrimer PAMAM on Water Dissociation at the Interface of a Bipolar Membrane, Journal of Membrane Science, 2004, 240, 141-147.
36) Xue YH, Wang N, Huang CH, Cheng YY, Xu TW*. Catalytic Water Dissociation at the Intermediate Layer of a Bipolar Membrane: The Role of Carboxylated Boltron H30. Journal of Membrane Science, 2009, 344, 129-135.
37) Xue YH, Xu TW*, Fu RQ, Cheng YY, Yang WH. Catalytic Water Dissociation Using Hyperbranched Aliphatic Polyester (Boltorn Series) as the Interface of a Bipolar Membrane. Journal of Colloid and Interface Science, 2007, 316, 604-611.
38) Xu ZH, Xu TW, Cheng YY, Ma ML, Xu P, Qu HO, Wen LP*, Colorimetric Determination of Polyamidoamine Dendrimers and Their Derivates Using a Simple and Rapid Ninhydrin Assay, Analytical Letters, 2008, 41, 444-455.
39) Wang JR, Cheng YY, Xu TW*, Current Patents of Dendrimers and Hyperbranched Polymers in Membranes, Recent Patents on Chemical Engineering, 2008, 1, 41-51.
40) Fu RQ, Cheng YY, Xu TW*, Yang WH, Fundamental Studies on the Intermediate Layer of a Bipolar Membrane. Part VI. Effect of the Coordinated Complex between Starburst Dendrimer PAMAM and Chromium (III) on Water Dissociation at the Interface of a Bipolar Membrane, Desalination, 2006, 196, 260-265.