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Dr. John S. O’ Neill

University of Cambridge, UK

Email: jso22@medschl.cam.ac.uk


2002-2006 Ph.D., Neurobiology, King’s College

1998-2002 M.Sc., Cellular and Molecular Biochemistry, University of Oxford

Publications (Selected)

  1. Circadian Clocks in Human Red Blood Cells. Nature 2011 Jan 27 (In press). John S. O’Neill and Akhilesh B. Reddy
  2. Circadian rhythms persist without transcription in a eukaryote. Nature 2011 Jan 27 (In press). John S. O’Neill, Gerben Van Ooijen, Laura Dixon, Carl Troein, Florence Corellou, Akhilesh B. Reddy, François-Yves Bouget, Andrew Millar.
  3. Daily cycling of genome-wide histone methylation. Science (In Press). Daniel Turner, John S. O’Neill, Akhilesh B. Reddy
  4. Shotgun proteomic analysis of the unicellular alga Ostreococcus tauri. Proteomics (In Press)Thierry Le Bihan, Sarah F. Martin, Eliane S. Chirnside, Gerben van Ooijen, Martin Barrios-Lerena, John S. O’Neill, Pavel V. Shliaha, Lorraine E. Kerr, Andrew J. Millar
  5. Multiple light inputs to a simple clock circuit allow complex biological rhythms.The Plant Journal 2011 Jan 10. [Epub ahead of print]Carl Troein, Florence Corellou, Laura Dixon, Gerben van Ooijen, John S. O'Neill, François-Yves Bouget, Andrew Millar. Circadian Clock Parameter Measurement: Characterisation of Clock Transcription.
  6. Factors using Surface Plasmon Resonance. J Biol Rhythms 2011 April 3 (In Press). John S. O’Neill, Gerben Van Ooijen, Thierry Le Bihan, Andrew Millar
  7. Healthy clocks, healthy body, healthy mind.Trends Cell Biol. 2010 Jan;20(1):36-44. Reddy AB & O'Neill JS. Using Higher-Order Dynamic Bayesian Networks to Model Periodic Data from the Circadian Clock of Arabidopsis Thaliana. PRIB 2009. Daly, R. Edwards, K. D. O'Neill, J. S. Aitken, S. Millar, A. J. Girolami, M. Cry1 Circadian Phase In Vitro: Wrapped Up with an E-Box. J Biol Rhythms. 2009 Feb; 24(1):16-24, J. M. Fustin, J. S. O’Neill, M. H. Hastings, D.G. Hazlerigg and H. Dardente Circadian Clocks can take a few transcriptional knocks. EMBO J. 2009 Jan 21;28(2):84-5. 
  8. John S. O’Neill, Increased Coherence of Circadian Rhythms in Mature Fibroblast Cultures.J Biol Rhythms. 2008 Dec;23(6):483-8. John S. O’Neill and Michael H. Hastings
  9. Cellular circadian pacemaking and the role of cytosolic rhythms.Curr Biol. 2008 Sep 9; 18(17):R805-15. 
  10. Michael H. Hastings, Elizabeth S. Maywood and John S. O’Neill. Cyclic AMP-dependent signaling as a multi-functional component of the cellular circadian clockwork of mammals. Science. 2008 May 16; 320(5878): 949-53. (Also see Perspectives and Editorial, same issue)
  11. John S. O’Neill, Elizabeth S. Maywood, Johanna E. Chesham, Joseph S. Takahashi & Michael H. Hastings, Circadian microRNA: A timely perspective.Curr Biol. 2007 Sep 4;17(17):R760-2. 
  12. John S. O'Neill & Michael Hastings, Genetic and molecular analysis of the central and peripheral circadian clockwork of mice. Cold Spring Harb Symp Quant Biol. 2007; 72:85-94. 
  13. Elizabeth S. Maywood, John S. O’Neill, Akhilesh B. Reddy, Johanna E. Chesham, Haydn M. Prosser, Charalambos P. Kyriacou, Sofia I. H. Godinho, Patrick M. Nolan & Michael H. Hastings, Refinement of a Radioreceptor Binding Assay for NAADP. Anal Biochem. 2007 Dec 1; 371(1):26-36. 
  14. Alexander M. Lewis, Roser Masgrau, Sridhar R. Vasudevan, Michiko Yamasaki, John S. O’Neill, Clive Garnham, Kristin James, Andrew Macdonald, Matthias Ziegler, Antony Galioneand Grant C. Churchill, The circadian clockwork of the suprachiasmatic nuclei: analysis of a cellular oscillatorthat drives endocrine rhythms. Endocrinology. 2007 Dec; 148(12):5624-34.
  15. Elizabeth S. Maywood, John S. O’Neill, Johanna E. Chesham & Michael Hastings, Circadian clocks: regulators of endocrine and metabolic rhythms. J Endocrinol. 2007 Nov; 195(2):187-98. Review. 
  16. Michael H. Hastings, John S. O’Neill & Elizabeth S. Maywood, Insight into the circadian clock within rat colonic epithelial cells. Gastroenterology. 2007 Oct;133(4):1240-9. 
  17. Sládek Martin, Rybová Markéta, Jindráková Zuzana, Zemanová Zdena, Polidarová Lenka, Mrnka Libor, O'Neill John, Pácha Ji, Sumová Alena, The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period.Science. 2007 May 11; 316(5826):897-900. 
  18. Godinho SI, Maywood ES, Shaw L, Tucci V, Barnard AR, Busino L, Pagano M, Kendall R, Quwailid MM, Romero MR, O'Neill J, Chesham JE, Brooker D, Lalanne Z, Hastings MH, Nolan PM. Chapter 15: Circadian timing in health and disease. Prog Brain Res. 2006; 153:253-69. 
  19. Maywood ES, O'Neill J, Wong GK, Reddy AB, Hastings MH. Circadian orchestration of the hepatic proteome. Curr Biol. 2006 Jun 6;16(11):1107-15. 
  20. Reddy AB, Karp NA, Maywood ES, Sage EA, Deery M, O'Neill JS, Wong GK, Chesham J, Odell M, Lilley KS, Kyriacou CP, Hastings MH. Synchronization and maintenance of timekeeping in suprachiasmatic circadian clock cells by neuropeptidergic signaling. Curr Biol. 2006 Mar 21; 16(6):599-605. 
  21. Maywood ES, Reddy AB, Wong GK, O'Neill JS, O'Brien JA, McMahon DG, Harmar AJ, Okamura H, Hastings MH. Circadian clocks: neural and peripheral pacemakers that impact upon the cell division cycle. Mutat Res. 2005 Jul 1; 574(1-2):76-91.
  22. Reddy AB, Wong GK, O'Neill J, Maywood ES, Hastings MH. Sperm Deliver a New Second Messenger. Curr Biol. 2003 Jan 21; 13(2): 125-8.