TITLE:
GABAb Receptor Antagonist (CGP35348) Improves Testosterone Induced Spatial Acquisition Impairment in Adult Male Rat
AUTHORS:
Pourang Shahrzad, Naghdi Nasser
KEYWORDS:
Spatial Learning and Memory, Hippocampus, Testosterone, CGP35348, Morris Water Maze
JOURNAL NAME:
Journal of Behavioral and Brain Science,
Vol.5 No.11,
October
22,
2015
ABSTRACT: The high density of
the androgen receptors in fundamental centers of learning and memory, such as
hippocampus, shows that there must be some relationship between the androgen receptors
and cognitive aspects. On the other hand, Gama Amino Butric Acid (GABA) plays a
controlling role in the balance of excitability and inhibitory states in the
cortex and hippocampus; a number of reports suggest that removal of the
influence of inhibitory GABA receptors lead to memory enhancement and
conversely the activation lead to memory inhibition. Sex steroids can rapidly influence
neural activity by increasing the binding affinity of neurotransmitters such as
GABAergic. To determine the effect of Testosterone on learning and memory in CA1 region of hippocampus, male albino Wistar rats (200 - 250 g) are bilaterally
cannulated into CA1 of hippocampus then different doses of Testosterone
enanthate or CGP35348 are injected through the cannulae for
assessing of acquisition, consolidation and retrieval in a single-day testing
protocol of Morris water maze task. After hippocampal microinjection with Testosterone
(T), acquisition is significantly impaired, while after treatment with CGP35348,
acquisition impairment caused by T can be significantly improved. Also T and
CGP35348 have no significant effect on consolidation and retrieval
stages of spatial memory. These results suggest that CGP35348 may
have therapeutic value in the treatment of Testosterone-induced acquisition impairment.