TITLE:
Clinical and Histological Profile of Breast Cancer at University Clinics of Kinshasa, Democratic Republic of Congo
AUTHORS:
Bisinkam Guillaume Malingisi, Mbangama Muela Andy, Mutombo Baleka Alex, Lumaya Ambis Joelle, Mukendi Tshitadi Jean, Muamba Nkongolo Freddy, Odimba Mpoy Jules, Kazadi Nkashama Bienvenu, Ndesanzim Otem Christian, Lotoy Banza Jésual, Etana Litambelo Serge, Ombha Loshima Ernest, Kabatantshi Mubengabantu Gérard
KEYWORDS:
Breast Cancer, Clinical and Histological Profile, University Clinics of Kinshasa
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.12 No.8,
August
17,
2022
ABSTRACT: Context: Breast cancer represents a significant public health problem concern
the world, given its frequency (20% to 25% of female cancers) and diagnosis
clinical stage with a particular frequency of locally advanced cancers and
inflammatory forms. Objectives: To describe the socio-demographic,
clinical and histological characteristics of breast cancer at the University
Clinics of Kinshasa. Methods: A descriptive and retrospective study was
completed at University Clinics of Kinshasa from 1 January 2003 to 30 July
2018, including 300 cases of breast cancer diagnosed and treated. Results:
The mean age of women at diagnosis was 47.5 ± 10.8 years. Most of the patients
were married, multipara with an average parity of 3.7 ± 2.5 and non-menopausal.
Breast mass was the main reason for medical visit (47.5%) and the majority of
patients consulted 12 months after the onset
of the disease (36.3%) at stage 3 (56%) and node extension was observed in
61.3%. The average size of the breast mass was 8.02 ± 3.7 cm. The
infiltrating ductal carcinoma was the most common histological type in 82.5% of
cases; the majority of tumors were histo-pronostic II in 47.5% of cases. 83% of
the tumors were hormonal-dependent. Only
35.9% of the tumors over-expressed the HER 2/Neu receptor. Conclusion:
Most patients consulted more than 12 months after the onset of the disease and
the diagnosis was made at advanced stages. The tumor was large at diagnosis.
The left breast was the most affected. The majority of tumors are of high
histopronostic grade and are hormonal-dependent.