[1]
|
International Diabetes Federation (2017) IDF Diabetes Atlas. 8th Edition, International Diabetes Federation, Brussels.
|
[2]
|
DeFronzo, R.A., Ferrannini, E., Groop, L., Henry, R.R., Herman, W.H., Holst, J.J., et al. (2015) Type 2 Diabetes Mellitus. Nature Reviews Disease Primers, 1, Article No. 15019. https://doi.org/10.1038/nrdp.2015.19
|
[3]
|
Ridderstråle, M. and Groop, L. (2009) Genetic Dissection of Type 2 Diabetes. Molecular and Cellular Endocrinology, 297, 10-17. https://doi.org/10.1016/j.mce.2008.10.002
|
[4]
|
Almind, K., Bjørbaek, C., Vestergaard, H., Hansen, T., Echwald, S. and Pedersen, O. (1993) Aminoacid Polymorphisms of Insulin Receptor Substrate-1 in Non-Insulin-Dependent Diabetes Mellitus. Lancet, 342, 828-832. https://doi.org/10.1016/0140-6736(93)92694-O
|
[5]
|
Visscher, P.M., Wray, N.R., Zhang, Q., Sklar, P., McCarthy, M.I., Brown, M.A. and Yang, J. (2017) 10 Years of GWAS Discovery: Biology, Function, and Translation. American Journal of Human Genetics, 101, 5-22. https://doi.org/10.1016/j.ajhg.2017.06.005
|
[6]
|
Vujkovic, M., Keaton, J.M., Lynch, J.A., Miller, D.R., Zhou, J., Tcheandjieu, C., et al. (2020) Discovery of 318 New Risk Loci for Type 2 Diabetes and Related Vascular Outcomes among 1.4 Million Participants in a Multi-Ancestry Meta-Analysis. Nature Genetics, 52, 680-691. https://doi.org/10.1101/19012690
|
[7]
|
Mahajan, A., Taliun, D., Thurner, M., Robertson, N.R., Torres, J.M., Rayner, N.W., et al. (2018) Fine-Mapping Type 2 Diabetes Loci to Single-Variant Resolution Using High-Density Imputation and Islet-Specific Epigenome Maps. Nature Genetics, 50, 1505-1513. https://doi.org/10.1038/s41588-018-0241-6
|
[8]
|
Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., Balkau, B., Heude, B., Charpentier, G., Hudson, T.J., Montpetit, A., Pshezhetsky, A.V., Prentki, M., Posner, B.I., Balding, D.J., Meyre, D., Polychronakos, C. and Froguel, P. (2007) A Genome-Wide Association Study Identifies Novel Risk Loci for Type 2 Diabetes. Nature, 445, 881-885. https://doi.org/10.1038/nature05616
|
[9]
|
Scott, L.J., Mohlke, K.L., Bonnycastle, L.L., Willer, C.J., Li, Y., Duren, W.L., et al. (2007) A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants. Science, 316, 1341-1345. https://doi.org/10.1126/science.1142382
|
[10]
|
Zeggini, E., Weedon, M.N., Lindgren, C.M., Frayling, T.M., Elliott, K.S., Lango, H., et al. (2007) Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes. Science, 316, 1336-41. [Erratum in: Science, 2007, 317(5841): 1035-1036]
|
[11]
|
Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, Saxena, R., Voight, B.F., Lyssenko, V., Burtt, N.P., de Bakker, P.I., Chen, H., et al. (2007) Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels. Science, 316, 1331-1336. https://doi.org/10.1126/science.1142358
|
[12]
|
Zeggini, E., Scott, L.J., Saxena, R., Voight, B.F., Marchini, J.L., Hu, T., et al. (2008) Meta-Analysis of Genome-Wide Association Data and Large-Scale Replication Identifies Additional Susceptibility Loci for Type 2 Diabetes. Nature Genetics, 40, 638-645. https://doi.org/10.1038/ng.120
|
[13]
|
Grarup, N., Andersen, G., Krarup, N.T., Albrechtsen, A., Schmitz, O., Jørgensen, T., Borch-Johnsen, K., Hansen, T. and Pedersen, O. (2008) Association Testing of Novel Type 2 Diabetes Risk Alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 Loci with Insulin Release, Insulin Sensitivity, and Obesity in a Population-Based Sample of 4,516 Glucose-Tolerant Middle-Aged Danes. Diabetes, 57, 2534-2540. https://doi.org/10.2337/db08-0436
|
[14]
|
Yasuda, K., Miyake, K., Horikawa, Y., Hara, K., Osawa, H., Furuta, H., et al. (2008) Variants in KCNQ1 Are Associated with Susceptibility to Type 2 Diabetes Mellitus. Nature Genetics, 40, 1092-1097. https://doi.org/10.1038/ng.207
|
[15]
|
Unoki, H., Takahashi, A., Kawaguchi, T., Hara, K., Horikoshi, M., Andersen, G., et al. (2008) SNPs in KCNQ1 Are Associated with Susceptibility to Type 2 Diabetes in East Asian and European Populations. Nature Genetics, 40, 1098-1102. https://doi.org/10.1038/ng.208
|
[16]
|
Voight, B.F., Scott, L.J., Steinthorsdottir, V., Morris, A.P., Dina, C., Welch, R.P., et al. (2010) Twelve Type 2 Diabetes Susceptibility Loci Identified through Large-Scale Association Analysis. Nature Genetics, 42, 579-589. https://doi.org/10.1038/ng.609
|
[17]
|
Tarasov, A.I., Nicolson, T.J., Riveline, J.P., Taneja, T.K., Baldwin, S.A., Baldwin, J.M., Charpentier, G., Gautier, J.F., Froguel, P., Vaxillaire, M. and Rutter, G.A. (2008) A Rare Mutation in ABCC8/SUR1 Leading to Altered ATP-Sensitive K+ Channel Activity and Beta-Cell Glucose Sensing Is Associated with Type 2 Diabetes in Adults. Diabetes, 57, 1595-1604. https://doi.org/10.2337/db07-1547
|
[18]
|
Bonnycastle, L.L., Willer, C.J., Conneely, K.N., Jackson, A.U., Burrill, C.P., Watanabe, R.M., et al. (2006) Common Variants in Maturity-Onset Diabetes of the Young Genes Contribute to Risk of Type 2 Diabetes in Finns. Diabetes, 55, 2534-2540. https://doi.org/10.2337/db06-0178
|
[19]
|
Johansson, S., Raeder, H., Eide, S.A., Midthjell, K., Hveem, K., Søvik, O., Molven, A. and Njølstad, P.R. (2007) Studies in 3,523 Norwegians and Meta-Analysis in 11,571 Subjects Indicate That Variants in the Hepatocyte Nuclear Factor 4 Alpha (HNF4A) P2 Region Are Associated with Type 2 Diabetes in Scandinavians. Diabetes, 56, 3112-3117. https://doi.org/10.2337/db07-0513
|
[20]
|
Weedon, M.N., Owen, K.R., Shields, B., Hitman, G., Walker, M., McCarthy, M.I., Love-Gregory, L.D., Permutt, M.A., Hattersley, A.T. and Frayling, T.M. (2004) Common Variants of the Hepatocyte Nuclear Factor-4α P2 Promoter Are Associated with Type 2 Diabetes in the U.K. Population. Diabetes, 53, 3002-3006. https://doi.org/10.2337/diabetes.53.11.3002
|
[21]
|
Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A.U., et al. (2010) New Genetic Loci Implicated in Fasting Glucose Homeostasis and Their Impact on Type 2 Diabetes Risk. Nature Genetics, 42, 105-116.
|
[22]
|
Prokopenko, I., Langenberg, C., Florez, J.C., Saxena, R., Soranzo, N., Thorleifsson, G., et al. (2009) Variants in MTNR1B Influence Fasting Glucose Levels. Nature Genetics, 41, 77-81. https://doi.org/10.1038/ng.290
|
[23]
|
Renström, F., Payne, F., Nordström, A., Brito, E.C., Rolandsson, O., Hallmans, G., Barroso, I., Nordström, P. and Franks, P.W.; GIANT Consortium (2009) Replication and Extension of Genome-Wide Association Study Results for Obesity in 4923 Adults from Northern Sweden. Human Molecular Genetics, 18, 1489-1496. https://doi.org/10.1093/hmg/ddp041
|
[24]
|
Frayling, T.M., Timpson, N.J., Weedon, M.N., Zeggini, E., Freathy, R.M., Lindgren, C.M., et al. (2007) A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity. Science, 316, 889-894. https://doi.org/10.1126/science.1141634
|
[25]
|
Chambers, J.C., Elliott, P., Zabaneh, D., Zhang, W., Li, Y., Froguel, P., Balding, D., Scott, J. and Kooner, J.S. (2008) Common Genetic Variation near MC4R Is Associated with Waist Circumference and Insulin Resistance. Nature Genetics, 40, 716-718. https://doi.org/10.1038/ng.156
|
[26]
|
Thorleifsson, G., Walters, G.B., Gudbjartsson, D.F., Steinthorsdottir, V., Sulem, P., Helgadottir, A., et al. (2009) Genome-Wide Association Yields New Sequence Variants at Seven Loci That Associate with Measures of Obesity. Nature Genetics, 41, 18-24. https://doi.org/10.1038/ng.274
|
[27]
|
Suzuki, K., Akiyama, M., Ishigaki, K., Kanai, M., Hosoe, J., Shojima, N., et al. (2019) Identification of 28 New Susceptibility Loci for Type 2 Diabetes in the Japanese Population. Nature Genetics, 51, 379-386. https://doi.org/10.1038/s41588-018-0332-4
|
[28]
|
Prasad, R.B. and Groop, L. (2019) Precision Medicine in Type 2 Diabetes. Journal of Internal Medicine, 285, 40-48. https://doi.org/10.1111/joim.12859
|
[29]
|
Pal, A. and McCarthy, M.I. (2013) The Genetics of Type 2 Diabetes and Its Clinical Relevance. Clinical Genetics, 83, 297-306. https://doi.org/10.1111/cge.12055
|
[30]
|
Keller, M.P., Rabaglia, M.E., Schueler, K.L., Stapleton, D.S., Gatti, D.M., Vincent, M., Mitok, K.A., Wang, Z., Ishimura, T., Simonett, S.P., Emfinger, C.H., Das, R., Beck, T., Kendziorski, C., Broman, K.W., Yandell, B.S., Churchill, G.A. and Attie, A.D. (2019) Gene Loci Associated with Insulin Secretion in Islets from Non-Diabetic Mice. Journal of Clinical Investigation, 129, 4419-4432. https://doi.org/10.1172/JCI129143
|
[31]
|
Peiris, H., Park, S., Louis, S., Gu, X., Lam, J.Y., Asplund, O., Ippolito, G.C., Bottino, R., Groop, L., Tucker, H. and Kim, S.K. (2018) Discovering Human Diabetes-Risk Gene Function with Genetics and Physiological Assays. Nature Communications, 9, Article No. 3855. https://doi.org/10.1038/s41467-018-06249-3
|
[32]
|
Czech, M.P. (2017) Insulin Action and Resistance in Obesity and Type 2 Diabetes. Nature Medicine, 23, 804-814. https://doi.org/10.1038/nm.4350
|
[33]
|
Kahn, S.E., Suvag, S., Wright, L.A. and Utzschneider, K.M. (2012) Interactions between Genetic Background, Insulin Resistance and β-Cell Function. Diabetes Obesity and Metabolism, 14, 46-56. https://doi.org/10.1111/j.1463-1326.2012.01650.x
|
[34]
|
Gambaro, G., Yabarek, T., Graziani, M.S., Gemelli, A., Abaterusso, C., Frigo, A.C., Marchionna, N., Citron, L., Bonfante, L., Grigoletto, F., Tata, S., Ferraro, P.M., Legnaro, A., Meneghel, G., Conz, P., Rizzotti, P., D’Angelo, A. and Lupo, A.; INCIPE Study Group (2010) Prevalence of CKD in Northeastern Italy: Results of the INCIPE Study and Comparison with NHANES. Clinical Journal of the American Society of Nephrology, 5, 1946-1953. https://doi.org/10.2215/CJN.02400310
|
[35]
|
Bianchi, C., Miccoli, R., Trombetta, M., Giorgino, F., Frontoni, S., Faloia, E., Marchesini, G., Dolci, M.A., Cavalot, F., Cavallo, G., Leonetti, F., Bonadonna, R.C. and Del Prato, S.; GENFIEV Investigators (2013) Elevated 1-Hour Postload Plasma Glucose Levels Identify Subjects with Normal Glucose Tolerance but Impaired β-Cell Function, Insulin Resistance, and Worse Cardiovascular Risk Profile: The GENFIEV Study. The Journal of Clinical Endocrinology & Metabolism, 98, 2100-2105. https://doi.org/10.1210/jc.2012-3971
|
[36]
|
Bonadonna, R.C., Heise, T., Arbet-Engels, C., Kapitza, C., Avogaro, A., Grimsby, J., Zhi, J., Grippo, J.F. and Balena, R. (2010) Piragliatin (RO4389620), a Novel Glucokinase Activator, Lowers Plasma Glucose Both in the Postabsorptive State and after a Glucose Challenge in Patients with Type 2 Diabetes Mellitus: A Mechanistic Study. The Journal of Clinical Endocrinology & Metabolism, 95, 5028-5036. https://doi.org/10.1210/jc.2010-1041
|
[37]
|
Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Treacher, D.F. and Turner, R.C. (1985) Homeostasis Model Assessment: Insulin Resistance and Beta-Cell Function from Fasting Plasma Glucose and Insulin Concentrations in Man. Diabetologia, 28, 412-419. https://doi.org/10.1007/BF00280883
|
[38]
|
Bonetti, S., Trombetta, M., Malerba, G., Boselli, L., Trabetti, E., Muggeo, M., et al. (2011) Variants and Haplotypes of TCF7L2 Are Associated with β-Cell Function in Patients with Newly Diagnosed Type 2 Diabetes: The Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1. The Journal of Clinical Endocrinology & Metabolism, 96, E389-E393. https://doi.org/10.1210/jc.2010-1677
|
[39]
|
Bonora, E., Trombetta, M., Dauriz, M., Travia, D., Cacciatori, V., Brangani, C., et al. (2020) Chronic Complications in Patients with Newly Diagnosed Type 2 Diabetes: Prevalence and Related Metabolic and Clinical Features: The Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 9. BMJ Open Diabetes Res Care, 8, e001549. https://doi.org/10.1136/bmjdrc-2020-001549
|
[40]
|
Bonetti, S., Trombetta, M., Boselli, M.L., Turrini, F., Malerba, G., Trabetti, E., Pignatti, P.F., Bonora, E. and Bonadonna, R.C. (2011) Variants of GCKR Affect Both β-Cell and Kidney Function in Patients with Newly Diagnosed Type 2 Diabetes: The Verona Newly Diagnosed Type 2 Diabetes Study 2. Diabetes Care, 34, 1205-1210. https://doi.org/10.2337/dc10-2218
|
[41]
|
Cali, A.M., Bonadonna, R.C., Trombetta, M., Weiss, R. and Caprio, S. (2008) Metabolic Abnormalities Underlying the Different Prediabetic Phenotypes in Obese Adolescents. The Journal of Clinical Endocrinology & Metabolism, 93, 1767-1773. https://doi.org/10.1210/jc.2007-1722
|
[42]
|
Weiss, R., Caprio, S., Trombetta, M., Taksali, S.E., Tamborlane, W.V. and Bonadonna, R. (2005) Beta-Cell Function across the Spectrum of Glucose Tolerance in Obese Youth. Diabetes, 54, 1735-1743. https://doi.org/10.2337/diabetes.54.6.1735
|
[43]
|
Cobelli, C., Toffolo, G.M., Dalla Man, C., et al. (2007) Assessment of Beta-Cell Function in Humans, Simultaneously with Insulin Sensitivity and Hepatic Extraction, from Intravenous and Oral Glucose Tests. American Journal of Physiology-Endocrinology and Metabolism, 293, E1-E15. https://doi.org/10.1152/ajpendo.00421.2006
|
[44]
|
Mari, A., Camastra, S., Toschi, E., et al. (2001) A Model for Glucose Control of Insulin Secretion during 24 h of Free Living. Diabetes, 50, S164-S168. https://doi.org/10.2337/diabetes.50.2007.S164
|
[45]
|
Van Cauter, E., Mestrez, F., Sturis, J. and Polonsky, K.S. (1992) Estimation of Insulin Secretion Rates from C-Peptide Levels. Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance. Diabetes, 41, 368-377.
|
[46]
|
Toschi, E., Camastra, S., Sironi, A.M., et al. (2002) Effect of Acute Hyperglycemia on Insulin Secretion in Humans. Diabetes, 51, S130-S133. https://doi.org/10.2337/diabetes.51.2007.S130
|
[47]
|
Foster, D.M., Boston, R.C., Jacquez, J.A. and Zech, L. (1989) A Resource Facility for Kinetic Analysis: Modeling Using the SAAM Computer Programs. Health Physics, 57, 457-466. https://doi.org/10.1097/00004032-198907001-00063
|
[48]
|
Lin, C.H., Yeakley, J.M., McDaniel, T.K. and Shen, R. (2009) Medium- to High-Throughput SNP Genotyping Using VeraCode Microbeads. Methods in Molecular Biology, 496, 129-142. https://doi.org/10.1007/978-1-59745-553-4_10
|
[49]
|
Davidovich, O., Kimmel, G. and Shamir, R. (2007) GEVALT: An Integrated Software Tool for Genotype Analysis. BMC Bioinformatics, 8, Article No. 36. https://doi.org/10.1186/1471-2105-8-36
|
[50]
|
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M.A., Bender, D., Maller, J., Sklar, P., de Bakker, P.I., Daly, M.J. and Sham, P.C. (2007) PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses. American Journal of Human Genetics, 81, 559-575. https://doi.org/10.1086/519795
|
[51]
|
Grant, S.F., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Manolescu, A., Sainz, J., et al. (2006) Variant of Transcription Factor 7-Like 2 (TCF7L2) Gene Confers Risk of Type 2 Diabetes. Nature Genetics, 38, 320-323. https://doi.org/10.1038/ng1732
|
[52]
|
Cauchi, S., El Achhab, Y., Choquet, H., Dina, C., Krempler, F., Weitgasser, R., Nejjari, C., Patsch, W., Chikri, M., Meyre, D. and Froguel, P. (2007) TCF7L2 Is Reproducibly Associated with Type 2 Diabetes in Various Ethnic Groups: A Global Meta-Analysis. Journal of Molecular Medicine (Berl), 85, 777-782. https://doi.org/10.1007/s00109-007-0203-4
|
[53]
|
Vaxillaire, M., Veslot, J., Dina, C., Proença, C., Cauchi, S., Charpentier, G., Tichet, J., Fumeron, F., Marre, M., Meyre, D., Balkau, B. and Froguel, P.; DESIR Study Group (2008) Impact of Common Type 2 Diabetes Risk Polymorphisms in the DESIR Prospective Study. Diabetes, 57, 244-254. https://doi.org/10.2337/db07-0615
|
[54]
|
Pearson, E.R. (2009) Translating TCF7L2: From Gene to Function. Diabetologia, 52, 1227-1230. https://doi.org/10.1007/s00125-009-1356-1
|
[55]
|
Gaulton, K.J., Nammo, T., Pasquali, L., Simon, J.M., Giresi, P.G., Fogarty, M.P., Panhuis, T.M., Mieczkowski, P., Secchi, A., Bosco, D., Berney, T., Montanya, E., Mohlke, K.L., Lieb, J.D. and Ferrer, J. (2010) A Map of Open Chromatin in Human Pancreatic Islets. Nature Genetics, 42, 255-259. https://doi.org/10.1038/ng.530
|
[56]
|
Laukkanen, O., Pihlajamäki, J., Lindström, J., Eriksson, J., Valle, T.T., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Tuomilehto, J., Uusitupa, M. and Laakso, M.; Finnish Diabetes Prevention Study Group (2004) Polymorphisms of the SUR1 (ABCC8) and Kir6.2 (KCNJ11) Genes Predict the Conversion from Impaired Glucose Tolerance to Type 2 Diabetes. The Finnish Diabetes Prevention Study. The Journal of Clinical Endocrinology & Metabolism, 89, 6286-6290. https://doi.org/10.1210/jc.2004-1204
|
[57]
|
Qin, L.J., Lv, Y. and Huang, Q.Y. (2013) Meta-Analysis of Association of Common Variants in the KCNJ11-ABCC8 Region with Type 2 Diabetes. Genetics and Molecular Research, 12, 2990-3002. https://doi.org/10.4238/2013.August.20.1
|
[58]
|
Wasson, J. and Permutt, M.A. (2008) Candidate Gene Studies Reveal That the WFS1 Gene Joins the Expanding List of Novel Type 2 Diabetes Genes. Diabetologia, 51, 391-393. https://doi.org/10.1007/s00125-007-0920-9
|
[59]
|
Eizirik, D.L., Cardozo, A.K. and Cnop, M. (2008) The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus. Endocrine Reviews, 29, 42-61. https://doi.org/10.1210/er.2007-0015
|
[60]
|
Rohayem, J., Ehlers, C., Wiedemann, B., et al. (2011) Diabetes and Neurodegeneration in Wolfram Syndrome: A Multicenter Study of Phenotype and Genotype. Diabetes Care, 34, 1503-1510. https://doi.org/10.2337/dc10-1937
|
[61]
|
Zeggini, E. (2007) A New Era for Type 2 Diabetes Genetics. Diabetic Medicine, 24, 1181-1186. https://doi.org/10.1111/j.1464-5491.2007.02274.x
|
[62]
|
Loos, R.J.F. and Yeo, G.S.H. (2014) The Bigger Picture of FTO: The First GWAS-Identified Obesity Gene. Nature Reviews Endocrinology, 10, 51-61. https://doi.org/10.1038/nrendo.2013.227
|
[63]
|
Cheng, M., Huang, X., Zhang, M. and Huang, Q. (2020) Computational and Functional Analyses of T2D GWAS SNPs for Transcription Factor Binding. Biochemical and Biophysical Research Communications, 523, 658-665. https://doi.org/10.1016/j.bbrc.2019.12.086
|
[64]
|
Wang, H., Liu, L., Zhao, J., Cui, G., Chen, C., Ding, H. and Wang, D.W. (2013) Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk. PLoS One, 8, e67665. https://doi.org/10.1371/journal.pone.0067665
|
[65]
|
Shi, Y., Li, Y., Wang, J., Wang, C., Fan, J., Zhao, J., et al. (2017) Meta-Analyses of the Association of G6PC2 Allele Variants with Elevated Fasting Glucose and Type 2 Diabetes. PLoS One, 12, e0181232. https://doi.org/10.1371/journal.pone.0181232
|
[66]
|
Schleinitz, D., Tönjes, A., Böttcher, Y., Dietrich, K., Enigk, B., Koriath, M., Scholz, G.H., Blüher, M., Zeggini, E., McCarthy, M.I., Kovacs, P. and Stumvoll, M. (2010) Lack of Significant Effects of the Type 2 Diabetes Susceptibility Loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on Diabetes and Quantitative Metabolic Traits. Hormone and Metabolic Research, 42, 14-22. https://doi.org/10.1055/s-0029-1233480
|
[67]
|
Trombetta, M., Bonetti, S., Boselli, M.L., Miccoli, R., Trabetti, E., Malerba, G., Pignatti, P.F., Bonora, E., Del Prato, S. and Bonadonna, R.C. (2013) PPARG2 Pro12Ala and ADAMTS9 rs4607103 as “Insulin Resistance Loci” and “Insulin Secretion Loci” in Italian Individuals. The GENFIEV Study and the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 4. Acta Diabetologica, 50, 401-408. https://doi.org/10.1007/s00592-012-0443-9
|
[68]
|
Li, X., Yang, M., Wang, H., Jia, Y., Yan, P., Boden, G., Yang, G. and Li, L. (2014) Overexpression of JAZF1 Protected ApoE-Deficient Mice from Atherosclerosis by Inhibiting Hepatic Cholesterol Synthesis via CREB-Dependent Mechanisms. International Journal of Cardiology, 177, 100-110. https://doi.org/10.1016/j.ijcard.2014.09.007
|
[69]
|
Yuan, L., Luo, X., Zeng, M., Zhang, Y., Yang, M., Zhang, L., Liu, R., Boden, G., Liu, H., Ma, Z.A., Li, L. and Yang, G. (2015) Transcription Factor TIP27 Regulates Glucose Homeostasis and Insulin Sensitivity in a PI3-Kinase/Akt-Dependent Manner in Mice. International Journal of Obesity (Lond), 39, 949-958. https://doi.org/10.1038/ijo.2015.5
|
[70]
|
Yuan, L., Luo, X., Zeng, M., Zhang, Y., Yang, M., Zhang, L., Liu, R., Boden, G., Liu, H., Ma, Z.A., Li, L. and Yang, G. (2015) Transcription Factor TIP27 Regulates Glucose Homeostasis and Insulin Sensitivity in a PI3-Kinase/Akt-Dependent Manner in Mice. International Journal of Obesity, 39, 949-958. https://doi.org/10.1038/ijo.2015.5
|
[71]
|
Ming, G.F., Xiao, D., Gong, W.J., Liu, H.X., Liu, J., Zhou, H.H. and Liu, Z.Q. (2014) JAZF1 Can Regulate the Expression of Lipid Metabolic Genes and Inhibit Lipid Accumulation in Adipocytes. Biochemical and Biophysical Research Communications, 445, 673-680. https://doi.org/10.1016/j.bbrc.2014.02.088
|
[72]
|
Kobiita, A., Godbersen, S., Araldi, E., Ghoshdastider, U., Schmid, M.W., Spinas, G., Moch, H. and Stoffel, M. (2020) The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress. Cell Reports, 32, 107846. https://doi.org/10.1016/j.celrep.2020.107846
|