TITLE:
Tranexamic Acid and Ethamsylate for Reducing Blood Loss in Patient Undergoing Lower Segment Cesarean Section at High Risk for Post-Partum Hemorrhage: A Pilot Study
AUTHORS:
Ahmed Alanwar, Sherif Akl, Sherif El-Mekawi, Marwan M. Gamal
KEYWORDS:
Blood Loss, Postpartum Hemorrhage, Elective Cesarean Delivery, Tranexam-ic Acid, Ethamsylate
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.10 No.9,
September
24,
2020
ABSTRACT: Objective: To assess the efficacy of intravenous tranexamic acid and ethamsylate in
reducing blood loss during and after elective lower segment cesarean delivery
in patients at high risk for postpartum hemorrhage. Methods: A
double-blind, randomized placebo-controlled study was undertaken of women
undergoing elective lower-segment cesarean delivery of a full-term pregnancy at
high risk for postpartum hemorrhage at Ain Sham University Maternity Hospital
in Cairo, Egypt, between January 2019 and October 2019. Patients were randomly
assigned (1:1) using computer-generated random numbers to receive either 1 g
tranexamic acid and 1 gm ethamsylate or 5% glucose (placebo) just after
delivery of the fetus. Prophylactic oxytocin was administered to all women.
Preoperative and postoperative complete blood count, hematocrit values, and
maternal weight were used to calculate the estimated blood loss (EBL) during
the cesarean, which was the primary outcome. Results: Analyses included
32 women in each group. Our results showed that tranexamic acid and ethamsylate
significantly reduced bleeding during and after cesarean delivery. The study
group’s total blood loss (149.22 ± 54.74 ml) was significantly less than the control group
(353.75 ± 115.56
ml) (p the control group (p the control group (p Conclusion: The use of tranexamic acid and ethamsylate during cesarean
delivery can significantly reduce blood loss during and after cesarean
delivery.