TITLE:
Stroke Due to Hypercoagulable State Can Mimic Multiple Sclerosis: A Case Report
AUTHORS:
Niknam Zahra, Saadat Alireza, Nabavi Seyed-Massood, Morsali Damineh, Hatami-Sadabadi Farhad, Kheirkhahan Meghdad, Mehdipour Baharak
KEYWORDS:
Hyperhomocysteinemia, Thrombophilia V, MTHFR (C677T) Gene Polymorphism, Activated Protein C Resistance, Multiple Sclerosis
JOURNAL NAME:
World Journal of Neuroscience,
Vol.7 No.3,
July
5,
2017
ABSTRACT: Introduction: Stroke is the second major cause of mortality worldwide and in several cases, and it may lead to disability. Factor V Leiden is a common genetic thrombophilia, which causes activated protein C (APC) resistance. Hyperhomocysteinemia and factor V Leiden deficiency, two independent coagulopathy factors, can lead to venous and arterial infarctions in multiple small and large arteries and veins anywhere in the body. Case Report: Here, we report a unique case in which both hyperhomocysteinemia and factor V Leiden deficiency are documented together with MTHFR (C677T) (Methylene Tetra Hydro Folate Reductase) gene polymorphism and activated protein C resistance respectively. Conclusion: More interestingly, the mode of presentation in this case highly resembled that of progressive multiple sclerosis; all signs and symptoms slowly progressed without any systemic signs at first few years. Further studies needed to assess current outcomes.