TITLE:
Sex Hormone Binding Globulin as a Predictor of in Vitro Fertilization Outcomes in Polycystic Ovary Syndrome: Our Results
AUTHORS:
Gaddas Meriem, Chaouache Nesrine, Ajina Mounir, Tabka Zouhair, Zaouali Ajina Monia
KEYWORDS:
SOPK, FIV, SHBG
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.6 No.7,
June
13,
2016
ABSTRACT: Objectives: in case
of Polycystic Ovary Syndrome (SOPK), predicting ovarian response before undertaking
risky in vitro fertilization (IVF)
proceeds is crucial. Sex Hormone Binding Globulin (SHBG) is introduced in
literature as an interesting indicator of follicle’s maturation and quality. The
aim of this study was to investigate whether serum SHBG levels are related to
fertilization outcomes in SOPK women undergoing IVF procedures. Methods: in a
prospective cohort study, we enrolled 61 SOPK women and 91 matched group of
infertile women. All of them were undergoing FIV/ICSI proceeds. SHBG levels
were performed in peripheral blood samples as well as others hormones
determination. Results: we noted significant differences between our study
group of SOPK patients and the Control group concerning the characteristics of
the ovarian response to gonadotrophins administration and concerning the
profile of biological proceeds’ outcomes. But no significant correlation
between SHBG and FIV/ICSI outcomes was found either in SOPK or in Control
group. Conclusions: our study provides evidence that SHBG can’t be considered
as a predictor of IVF outcomes because production of this steroid-binding
protein depends on many parameters such as metabolic disorders frequently
associated with SOPK.