[1]
|
Spicer, A.J. and Jalkanen, S. (2021) Why Haven’t We Found an Effective Treatment for COVID-19? Frontiers in Immunology, 12, Article ID: 644850.
https://doi.org/10.3389/fimmu.2021.644850
|
[2]
|
Shi, L., et al. (2021) Mesenchymal Stem Cell Therapy for Severe COVID-19. Signal Transduction and Targeted Therapy, 6, Article No. 339.
https://doi.org/10.1038/s41392-021-00754-6
|
[3]
|
Yang, L., Xie, X., Tu, Z., Fu, J., Xu, D. and Zhou, Y. (2021) The Signal Pathways and Treatment of Cytokine Storm in COVID-19. Signal Transduction and Targeted Therapy, 6, Article No. 255. https://doi.org/10.1038/s41392-021-00679-0
|
[4]
|
Henderson, L.A., et al. (2020) On the Alert for Cytokine Storm: Immunopathology in COVID-19. Arthritis & Rheumatology, 72, 1059-1063.
https://doi.org/10.1002/art.41285
|
[5]
|
Riedel, R.N., Pérez-Pérez, A., Sánchez-Margalet, V., Varone, C.L. and Maymó, J.L. (2021) Stem Cells and COVID-19: Are the Human Amniotic Cells a New Hope for Therapies against the SARS-CoV-2 Virus? Stem Cell Research & Therapy, 12, Article No. 155. https://doi.org/10.1186/s13287-021-02216-w
|
[6]
|
Dominici, M., et al. (2006) Minimal Criteria for Defining Multipotent Mesenchymal Stromal Cells. The International Society for Cellular Therapy Position Statement. Cytotherapy, 8, 315-317. https://doi.org/10.1080/14653240600855905
|
[7]
|
Durand, N., Mallea, J. and Zubair, A.C. (2020) Insights into the Use of Mesenchymal Stem Cells in COVID-19 Mediated Acute Respiratory Failure. npj Regenerative Medicine, 5, Article No. 17. https://doi.org/10.1038/s41536-020-00105-z
|
[8]
|
Gao, F., et al. (2016) Mesenchymal Stem Cells and Immunomodulation: Current Status and Future Prospects. Cell Death & Disease, 7, e2062.
https://doi.org/10.1038/cddis.2015.327
|
[9]
|
Xu, R., Feng, Z. and Wang, F.-S. (2022) Mesenchymal Stem Cell Treatment for COVID-19. eBioMedicine, 77, Article ID: 103920.
https://doi.org/10.1016/j.ebiom.2022.103920
|
[10]
|
Kean, T.J., Lin, P., Caplan, A.I. and Dennis, J.E. (2013) MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune Modulation. Stem Cells International, 2013, e732742. https://doi.org/10.1155/2013/732742
|
[11]
|
Deng, Y., et al. (2020) Clinical Characteristics of Fatal and Recovered Cases of Coronavirus Disease 2019 in Wuhan, China: A Retrospective Study. Chinese Medical Journal, 133, 1261-1267. https://doi.org/10.1097/CM9.0000000000000824
|
[12]
|
Moll, G., Drzeniek, N., Kamhieh-Milz, J., Geissler, S., Volk, H.-D. and Reinke, P. (2020) MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy. Frontiers in Immunology, 11, Article 1091.
https://doi.org/10.3389/fimmu.2020.01091
|
[13]
|
Yao, W., Shi, L., Zhang, Y., Dong, H. and Zhang, Y. (2022) Mesenchymal Stem/Stromal Cell Therapy for COVID-19 Pneumonia: Potential Mechanisms, Current Clinical Evidence, and Future Perspectives. Stem Cell Research & Therapy, 13, Article No. 124. https://doi.org/10.1186/s13287-022-02810-6
|
[14]
|
Leng, Z., et al. (2020) Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia. Aging and Disease, 11, 216-228.
|
[15]
|
Meng, F., et al. (2020) Human Umbilical Cord-Derived Mesenchymal Stem Cell Therapy in Patients with COVID-19: A Phase 1 Clinical Trial. Signal Transduction and Targeted Therapy, 5, Article No. 172.
https://doi.org/10.1038/s41392-020-00286-5
|
[16]
|
Zhang, Y., et al. (2020) Intravenous Infusion of Human Umbilical Cord Wharton’s Jelly-Derived Mesenchymal Stem Cells as a Potential Treatment for Patients with COVID-19 Pneumonia. Stem Cell Research & Therapy, 11, Article No. 207.
https://doi.org/10.1186/s13287-020-01725-4
|
[17]
|
Lanzoni, G., et al. (2021) Umbilical Cord Mesenchymal Stem Cells for COVID-19 Acute Respiratory Distress Syndrome: A Double-Blind, Phase 1/2a, Randomized Controlled Trial. STEM CELLS Translational Medicine, 10, 660-673.
https://doi.org/10.1002/sctm.20-0472
|
[18]
|
Adugna, D.G. (2021) Current Clinical Application of Mesenchymal Stem Cells in the Treatment of Severe COVID-19 Patients: Review. Stem Cells and Cloning: Advances and Applications, 14, 71-80. https://doi.org/10.2147/SCCAA.S333800
|
[19]
|
Iohara, K., Zheng, L., Ito, M., Tomokiyo, A., Matsushita, K. and Nakashima, M. (2006) Side Population Cells Isolated from Porcine Dental Pulp Tissue with Self-Renewal and Multipotency for Dentinogenesis, Chondrogenesis, Adipogenesis, and Neurogenesis. Stem Cells, 24, 2493-2503. https://doi.org/10.1634/stemcells.2006-0161
|
[20]
|
Andrukhov, O., Behm, C., Blufstein, A. and Rausch-Fan, X. (2019) Immunomodulatory Properties of Dental Tissue-Derived Mesenchymal Stem Cells: Implication in Disease and Tissue Regeneration. World Journal of Stem Cells, 11, 604-617.
https://doi.org/10.4252/wjsc.v11.i9.604
|
[21]
|
Tsutsui, T.W. (2020) Dental Pulp Stem Cells: Advances to Applications. Stem Cells and Cloning: Advances and Applications, 13, 33-42.
https://doi.org/10.2147/SCCAA.S166759
|
[22]
|
Ye, Q., et al. (2020) Safety and Efficacy Assessment of Allogeneic Human Dental Pulp Stem Cells to Treat Patients with Severe COVID-19: Structured Summary of a Study Protocol for a Randomized Controlled Trial (Phase I/II). Trials, 21, Article No. 520. https://doi.org/10.1186/s13063-020-04380-5
|
[23]
|
Croci, S., et al. (2021) Human Dental Pulp Stem Cells Modulate Cytokine Production in vitro by Peripheral Blood Mononuclear Cells from Coronavirus Disease 2019 Patients. Frontiers in Cell and Developmental Biology, 8, Article ID: 609204.
https://doi.org/10.3389/fcell.2020.609204
|
[24]
|
Di Tinco, R., et al. (2021) Role of PD-L1 in Licensing immunoregulatory Function of Dental Pulp Mesenchymal Stem Cells. Stem Cell Research & Therapy, 12, Article No. 598. https://doi.org/10.1186/s13287-021-02664-4
|
[25]
|
Part 15 Hearing: Draft Guidances Relating to the Regulation of human Cells, Tissues, or Cellular or Tissue-Based Products. 277.
|
[26]
|
Center for Biologics Evaluation and Research, US Food and Drug Administration (2020) Consumer Alert on Regenerative Medicine Products Including Stem Cells and Exosomes. FDA, July.
https://www.fda.gov/vaccines-blood-biologics/consumers-biologics/consumer-alert-regenerative-medicine-products-including-stem-cells-and-exosomes
|
[27]
|
Bartel, D.P. (2009) MicroRNAs: Target Recognition and Regulatory Functions. Cell, 136, 215-233. https://doi.org/10.1016/j.cell.2009.01.002
|
[28]
|
Bartel, D.P. (2018) Metazoan MicroRNAs. Cell, 173, 20-51.
https://doi.org/10.1016/j.cell.2018.03.006
|
[29]
|
Bulut, Ö. and Gürsel, İ. (2020) Mesenchymal Stem Cell Derived Extracellular Vesicles: Promising Immunomodulators against Autoimmune, Autoinflammatory Disorders and SARS-CoV-2 Infection. Turkish Journal of Biology, 44, Article 14.
https://doi.org/10.3906/biy-2002-79
|
[30]
|
Öztürk, S., Elçin, A.E. and Elçin, Y.M. (2020) Mesenchymal Stem Cells for Coronavirus (COVID-19)-Induced Pneumonia: Revisiting the Paracrine Hypothesis with New Hopes? Aging and Disease, 11, 477-479. https://doi.org/10.14336/AD.2020.0403
|
[31]
|
Schultz, I.C., Bertoni, A.P.S. and Wink, M.R. (2021) Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying miRNA as a Potential Multi Target Therapy to COVID-19: An in Silico Analysis. Stem Cell Reviews and Reports, 17, 341-356.
https://doi.org/10.1007/s12015-021-10122-0
|
[32]
|
Brodin, P. (2021) Immune Determinants of COVID-19 Disease Presentation and Severity. Nature Medicine, 27, 28-33. https://doi.org/10.1038/s41591-020-01202-8
|
[33]
|
Liu, J., Lu, F., Chen, Y., Plow, E. and Qin, J. (2022) Integrin Mediates Cell Entry of the SARS-CoV-2 Virus Independent of Cellular Receptor ACE2. Journal of Biological Chemistry, 298, Article ID: 101710. https://doi.org/10.1016/j.jbc.2022.101710
|
[34]
|
Cantuti-Castelvetri, L., et al. (2020) Neuropilin-1 Facilitates SARS-CoV-2 Cell Entry and Infectivity. Science, 370, 856-860. https://doi.org/10.1126/science.abd2985
|
[35]
|
Hoffmann, M., Kleine-Weber, H., et al. (2020) SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell, 181, 271-280.E8. https://doi.org/10.1016/j.cell.2020.02.052
|
[36]
|
Jackson, C.B., Farzan, M., Chen, B. and Choe, H. (2022) Mechanisms of SARS-CoV-2 Entry into Cells. Nature Reviews Molecular Cell Biology, 23, 3-20.
https://doi.org/10.1038/s41580-021-00418-x
|
[37]
|
Swanson, K.V., Deng, M. and Ting, J.P.-Y. (2019) The NLRP3 Inflammasome: Molecular Activation and Regulation to Therapeutics. Nature Reviews Immunology, 19, 477-489. https://doi.org/10.1038/s41577-019-0165-0
|
[38]
|
Man, S.M., Karki, R. and Kanneganti, T.-D. (2017) Molecular Mechanisms and Functions of Pyroptosis, Inflammatory Caspases and Inflammasomes in Infectious Diseases. Immunological Reviews, 277, 61-75. https://doi.org/10.1111/imr.12534
|
[39]
|
Garay-Sevilla, M.E., Rojas, A., Portero-Otin, M. and Uribarri, J. (2021) Dietary AGEs as Exogenous Boosters of Inflammation. Nutrients, 13, Article 2802.
https://doi.org/10.3390/nu13082802
|
[40]
|
Ferreira, A.C., et al. (2021) SARS-CoV-2 Engages Inflammasome and Pyroptosis in Human Primary Monocytes. Cell Death Discovery, 7, Article No. 116.
https://doi.org/10.1038/s41420-021-00477-1
|
[41]
|
Marchetti, C., Mould, K., Tengesdal, I.W., Janssen, W.J. and Dinarello, C.A. (2021) Targeting of the NLRP3 Inflammasome for Early COVID-19. bioRxiv.
https://doi.org/10.1101/2021.02.24.432734
|
[42]
|
de Rivero Vaccari, J.C., Dietrich, W.D., Keane, R.W. and de Rivero Vaccari, J.P. (2020) The Inflammasome in Times of COVID-19. Frontiers in Immunology, 11, Article ID: 583373. https://doi.org/10.3389/fimmu.2020.583373
|
[43]
|
Cron, R.Q. (2021) COVID-19 Cytokine Storm: Targeting the Appropriate Cytokine. The Lancet Rheumatology, 3, e236-e237.
https://doi.org/10.1016/S2665-9913(21)00011-4
|
[44]
|
Fajgenbaum D.C. and June, C.H. (2020) Cytokine Storm. New England Journal of Medicine, 383, 2255-2273. https://doi.org/10.1056/NEJMra2026131
|
[45]
|
Hojyo, S., et al. (2020) How COVID-19 Induces Cytokine Storm with High Mortality. Inflammation and Regeneration, 40, Article No. 37.
https://doi.org/10.1186/s41232-020-00146-3
|
[46]
|
Lucas, C., et al. (2020) Longitudinal Analyses Reveal Immunological Misfiring in Severe COVID-19. Nature, 584, 463-469.
https://doi.org/10.1038/s41586-020-2588-y
|
[47]
|
Morris, S.B., et al. (2020) Case Series of Multisystem Inflammatory Syndrome in Adults Associated with SARS-CoV-2 Infection—United Kingdom and United States, March-August 2020. Morbidity and Mortality Weekly Report (MMWR), 69, 1450-1456. https://doi.org/10.15585/mmwr.mm6940e1
|
[48]
|
Sokol, C.L. and Luster, A.D. (2015) The Chemokine System in Innate Immunity. Cold Spring Harbor Perspectives in Biology, 7, a016303.
https://doi.org/10.1101/cshperspect.a016303
|
[49]
|
Tau, G. and Rothman, P. (1999) Biologic Functions of the IFN-Gamma Receptors. Allergy, 54, 1233-1251. https://doi.org/10.1034/j.1398-9995.1999.00099.x
|
[50]
|
Galani, I.-E., et al. (2021) Untuned Antiviral Immunity in COVID-19 Revealed by Temporal Type I/III Interferon Patterns and Flu Comparison. Nature Immunology, 22, 32-40. https://doi.org/10.1038/s41590-020-00840-x
|
[51]
|
Del Valle, D.M., et al. (2020) An Inflammatory Cytokine Signature Predicts COVID-19 Severity and Survival. Nature Medicine, 26, 1636-1643.
https://doi.org/10.1038/s41591-020-1051-9
|
[52]
|
Huang, C., et al. (2020) Clinical Features of Patients Infected with 2019 Novel Coronavirus in Wuhan, China. The Lancet, 395, 497-506.
https://doi.org/10.1016/S0140-6736(20)30183-5
|
[53]
|
Deshmane, S.L., Kremlev, S., Amini, S. and Sawaya, B.E. (2009) Monocyte Chemoattractant Protein-1 (MCP-1): An Overview. Journal of Interferon & Cytokine Research, 29, 313-326. https://doi.org/10.1089/jir.2008.0027
|
[54]
|
Jøntvedt Jørgensen, M., et al. (2020) Increased Interleukin-6 and Macrophage Chemoattractant Protein-1 Are Associated with Respiratory Failure in COVID-19. Scientific Reports, 10, Article No. 21697. https://doi.org/10.1038/s41598-020-78710-7
|
[55]
|
Hasan, A., Al-Ozairi, E., Al-Baqsumi, Z., Ahmad, R. and Al-Mulla, F. (2021) Cellular and Humoral Immune Responses in COVID-19 and Immunotherapeutic Approaches. ImmunoTargets and Therapy, 10, 63-85.
https://doi.org/10.2147/ITT.S280706
|
[56]
|
Xu, Z., et al. (2020) Pathological Findings of COVID-19 Associated with Acute Respiratory Distress Syndrome. The Lancet Respiratory Medicine, 8, 420-422.
https://doi.org/10.1016/S2213-2600(20)30076-X
|
[57]
|
Guan, W., et al. (2020) Clinical Characteristics of Coronavirus Disease 2019 in China. New England Journal of Medicine, 382, 1708-1720.
https://doi.org/10.1056/NEJMoa2002032
|
[58]
|
Farshi, E., Kasmapur, B. and Arad, A. (2021) Investigation of Immune Cells on Elimination of Pulmonary-Infected COVID-19 and Important Role of Innate Immunity, Phagocytes. Reviews in Medical Virology, 31, e2158.
https://doi.org/10.1002/rmv.2158
|
[59]
|
Kigi, D., et al. (1994) Cytotoxicity Mediated by T Cells and Natural Killer Cells Is Greatly Impaired in Perforin-Deficient Mice. Nature, 369, 31-37.
https://doi.org/10.1038/369031a0
|
[60]
|
Jiang, Y., et al. (2020) COVID-19 Pneumonia: CD8+ T and NK Cells Are Decreased in Number but Compensatory Increased in Cytotoxic Potential. Clinical Immunology, 218, Article ID: 108516. https://doi.org/10.1016/j.clim.2020.108516
|
[61]
|
Wang, F., et al. (2020) The Laboratory Tests and Host Immunity of COVID-19 Patients with Different Severity of Illness. JCI Insight, 5, e137799.
https://doi.org/10.1172/jci.insight.137799
|
[62]
|
Bobcakova, A., et al. (2021) Immune Profile in Patients with COVID-19: Lymphocytes Exhaustion Markers in Relationship to Clinical Outcome. Frontiers in Cellular and Infection Microbiology, 11, Article ID: 646688.
https://doi.org/10.3389/fcimb.2021.646688
|
[63]
|
Zhao, Q., et al. (2020) Lymphopenia Is Associated with Severe Coronavirus Disease 2019 (COVID-19) Infections: A Systemic Review and Meta-Analysis. International Journal of Infectious Diseases, 96, 131-135.
https://doi.org/10.1016/j.ijid.2020.04.086
|
[64]
|
Jiang, M., et al. (2020) T-Cell Subset Counts in Peripheral Blood Can Be Used as Discriminatory Biomarkers for Diagnosis and Severity Prediction of Coronavirus Disease 2019. The Journal of Infectious Diseases, 222, 198-202.
https://doi.org/10.1093/infdis/jiaa252
|
[65]
|
Zheng, M., et al. (2020) Functional Exhaustion of Antiviral Lymphocytes in COVID-19 Patients. Cellular & Molecular Immunology, 17, 533-535.
https://doi.org/10.1038/s41423-020-0402-2
|
[66]
|
Walls, A.C., Park, Y.-J., Tortorici, M.A., Wall, A., McGuire, A.T. and Veesler, D. (2020) Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein. Cell, 181, 281-292.e6. https://doi.org/10.1016/j.cell.2020.02.058
|
[67]
|
Sterlin, D., et al. (2021) IgA Dominates the Early Neutralizing Antibody Response to SARS-CoV-2. Science Translational Medicine, 13.
https://doi.org/10.1126/scitranslmed.abd2223
|
[68]
|
Chansaenroj, J., et al. (2021) Detection of SARS-CoV-2-Specific Antibodies via Rapid Diagnostic Immunoassays in COVID-19 Patients. Virology Journal, 18, Article No. 52. https://doi.org/10.1186/s12985-021-01530-2
|
[69]
|
Dogan, M., et al. (2020) Novel SARS-CoV-2 Specific Antibody and Neutralization Assays Reveal Wide Range of Humoral Immune Response during COVID-19. medRxiv. https://doi.org/10.1101/2020.07.07.20148106
|
[70]
|
Evans, M.J. and Kaufman, M.H. (1981) Establishment in Culture of Pluripotential Cells from Mouse Embryos. Nature, 292, 154-156. https://doi.org/10.1038/292154a0
|
[71]
|
Dwivedi, S. and Sharma, P. (2018) Stem Cell Biology: A New Hope in Regenerations and Replenishments Therapy. Indian Journal of Clinical Biochemistry, 33, 369-371. https://doi.org/10.1007/s12291-018-0792-4
|
[72]
|
Farini, A., Sitzia, C., Erratico, S., Meregalli, M. and Torrente, Y. (2014) Clinical Applications of Mesenchymal Stem Cells in Chronic Diseases. Stem Cells International, 2014, Article ID: 306573. https://doi.org/10.1155/2014/306573
|
[73]
|
Joyce, N., Annett, G., Wirthlin, L., Olson, S., Bauer, G. and Nolta, J.A. (2010) Mesenchymal Stem Cells for the Treatment of Neurodegenerative Disease. Regenerative Medicine, 5, 933-946. https://doi.org/10.2217/rme.10.72
|
[74]
|
Wang, S., Qu, X. and Zhao, R.C. (2012) Clinical Applications of Mesenchymal Stem Cells. Journal of Hematology & Oncology, 5, Article No. 19.
https://doi.org/10.1186/1756-8722-5-19
|
[75]
|
Wei, X., Yang, X., Han, Z., Qu, F., Shao, L. and Shi, Y. (2013) Mesenchymal Stem Cells: A New Trend for Cell Therapy. Acta Pharmacologica Sinica, 34, 747-754.
https://doi.org/10.1038/aps.2013.50
|
[76]
|
Parekkadan, B. and Milwid, J.M. (2010) Mesenchymal Stem Cells as Therapeutics. Annual Review of Biomedical Engineering, 12, 87-117.
https://doi.org/10.1146/annurev-bioeng-070909-105309
|
[77]
|
Kouris, N.A., et al. (2012) Directed Fusion of Mesenchymal Stem Cells with Cardiomyocytes via VSV-G Facilitates Stem Cell Programming. Stem Cells International, 2012, Article ID: 414038. https://doi.org/10.1155/2012/414038
|
[78]
|
Hofer, H.R. and Tuan, R.S. (2016) Secreted Trophic Factors of Mesenchymal Stem Cells Support Neurovascular and Musculoskeletal Therapies. Stem Cell Research & Therapy, 7, Article No. 131. https://doi.org/10.1186/s13287-016-0394-0
|
[79]
|
Jackson, M.V., et al. (2016) Mitochondrial Transfer via Tunneling Nanotubes Is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the in Vitro and in Vivo Models of ARDS. Stem Cells, 34, 2210-2223. https://doi.org/10.1002/stem.2372
|
[80]
|
Robbins, P.D. and Morelli, A.E. (2014) Regulation of Immune Responses by Extracellular Vesicles. Nature Reviews Immunology, 14, 195-208.
https://doi.org/10.1038/nri3622
|
[81]
|
Liang, B., et al. (2020) Clinical Remission of a Critically Ill COVID-19 Patient Treated by Human Umbilical Cord Mesenchymal Stem Cells. Medicine (Baltimore), 99, e21429. https://doi.org/10.1097/MD.0000000000021429
|
[82]
|
Sánchez-Guijo, F., et al. (2020) Adipose-Derived Mesenchymal Stromal Cells for the Treatment of Patients with Severe SARS-CoV-2 Pneumonia Requiring Mechanical Ventilation. A Proof of Concept Study. eClinicalMedicine, 25, Article ID: 100454.
https://doi.org/10.1016/j.eclinm.2020.100454
|
[83]
|
Avanzini, M.A., et al. (2021) Human Mesenchymal Stromal Cells Do Not Express ACE2 and TMPRSS2 and Are Not Permissive to SARS-CoV-2 Infection. STEM CELLS Translational Medicine, 10, 636-642. https://doi.org/10.1002/sctm.20-0385
|
[84]
|
Schäfer, R., et al. (2021) Human Mesenchymal Stromal Cells Are Resistant to SARS-CoV-2 Infection under Steady-State, Inflammatory Conditions and in the Presence of SARS-CoV-2-Infected Cells. Stem Cell Reports, 16, 419-427.
https://doi.org/10.1016/j.stemcr.2020.09.003
|
[85]
|
Sakaguchi, W., et al. (2020) Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity. International Journal of Molecular Sciences, 21, Article 6000.
https://doi.org/10.3390/ijms21176000
|
[86]
|
Durand, N., Russell, A. and Zubair, A.C. (2019) Effect of Comedications and Endotoxins on Mesenchymal Stem Cell Secretomes, Migratory and Immunomodulatory Capacity. Journal of Clinical Medicine, 8, Article 497.
https://doi.org/10.3390/jcm8040497
|
[87]
|
Russell, A.L., Lefavor, R., Durand, N., Glover, L. and Zubair, A.C. (2018) Modifiers of Mesenchymal Stem Cell Quantity and Quality. Transfusion, 58, 1434-1440.
https://doi.org/10.1111/trf.14597
|
[88]
|
Shu, L., et al. (2020) Treatment of Severe COVID-19 with Human Umbilical Cord Mesenchymal Stem Cells. Stem Cell Research & Therapy, 11, Article No. 361.
https://doi.org/10.1186/s13287-020-01875-5
|
[89]
|
de Witte, S.F.H., et al. (2018) Immunomodulation BY Therapeutic Mesenchymal Stromal Cells (MSC) Is Triggered Through Phagocytosis of MSC By Monocytic Cells. Stem Cells, 36, 602-615. https://doi.org/10.1002/stem.2779
|
[90]
|
Hu, C. and Li, L. (2019) The Immunoregulation of Mesenchymal Stem Cells Plays a Critical Role in Improving the Prognosis of Liver Transplantation. Journal of Translational Medicine, 17, Article No. 412. https://doi.org/10.1186/s12967-019-02167-0
|
[91]
|
Golchin, A., Seyedjafari, E. and Ardeshirylajimi, A. (2020) Mesenchymal Stem Cell Therapy for COVID-19: Present or Future. Stem Cell Reviews and Reports, 16, 427-433. https://doi.org/10.1007/s12015-020-09973-w
|
[92]
|
Lu, Z., et al. (2019) Mesenchymal Stem Cells Induce Dendritic Cell Immune Tolerance via Paracrine Hepatocyte Growth Factor to Alleviate Acute Lung Injury. Stem Cell Research & Therapy, 10, Article No. 372.
https://doi.org/10.1186/s13287-019-1488-2
|
[93]
|
Park, M., Kim, Y.-H., Ryu, J.-H., Woo, S.-Y. and Ryu, K.-H. (2015) Immune Suppressive Effects of Tonsil-Derived Mesenchymal Stem Cells on Mouse Bone-Marrow-Derived Dendritic Cells. Stem Cells International, 2015, Article ID: 106540.
https://doi.org/10.1155/2015/106540
|
[94]
|
Spaggiari, G.M. and Moretta, L. (2013) Interactions between Mesenchymal Stem Cells and Dendritic Cells. In: Weyand, B., Dominici, M., Hass, R., Jacobs, R. and Kasper, C., Eds., Mesenchymal Stem Cells—Basics and Clinical Application II, Springer, Berlin, Heidelberg, 199-208. https://doi.org/10.1007/10_2012_154
|
[95]
|
Raffaghello, L., et al. (2008) Human Mesenchymal Stem Cells Inhibit Neutrophil Apoptosis: A Model for Neutrophil Preservation in the Bone Marrow Niche. Stem Cells, 26, 151-162. https://doi.org/10.1634/stemcells.2007-0416
|
[96]
|
Lee, S., Zhang, Q.Z., Karabucak, B. and Le, A.D. (2016) DPSCs from Inflamed Pulp Modulate Macrophage Function via the TNF-α/IDO Axis. Journal of Dental Research, 95, 1274-1281. https://doi.org/10.1177/0022034516657817
|
[97]
|
Zhang, Y., Chen, Y. and Meng, Z. (2020) Immunomodulation for Severe COVID-19 Pneumonia: The State of the Art. Frontiers in Immunology, 11, Article ID: 577442.
https://doi.org/10.3389/fimmu.2020.577442
|
[98]
|
Loke, X.Y., Imran, S.A.M., Tye, G.J., Wan Kamarul Zaman, W.S. and Nordin, F. (2021) Immunomodulation and Regenerative Capacity of MSCs for Long-COVID. International Journal of Molecular Sciences, 22, Article ID: 12421.
https://doi.org/10.3390/ijms222212421
|
[99]
|
Tsyb, A.F., et al. (2008) In Vitro Inhibitory Effect of Mesenchymal Stem Cells on Zymosan-Induced Production of Reactive Oxygen Species. Bulletin of Experimental Biology and Medicine, 146, 158-164. https://doi.org/10.1007/s10517-008-0238-8
|
[100]
|
Vasandan, A.B., Jahnavi, S., Shashank, C., Prasad, P., Kumar, A. and Prasanna, S.J. (2016) Human Mesenchymal Stem Cells Program Macrophage Plasticity by Altering Their Metabolic Status via a PGE 2-Dependent Mechanism. Scientific Reports, 6, Article No. 38308. https://doi.org/10.1038/srep38308
|
[101]
|
Le Blanc, K. and Davies, L.C. (2015) Mesenchymal Stromal Cells and the Innate Immune Response. Immunology Letters, 168, 140-146.
https://doi.org/10.1016/j.imlet.2015.05.004
|
[102]
|
Chen, B., Ni, Y., Liu, J., Zhang, Y. and Yan, F. (2018) Bone Marrow-Derived Mesenchymal Stem Cells Exert Diverse Effects on Different Macrophage Subsets. Stem Cells International, 2018, Article ID: 8348121.
https://doi.org/10.1155/2018/8348121
|
[103]
|
Fan, L., Hu, C., Chen, J., Cen, P., Wang, J. and Li, L. (2016) Interaction between Mesenchymal Stem Cells and B-Cells. International Journal of Molecular Sciences, 17, Article 650. https://doi.org/10.3390/ijms17050650
|
[104]
|
Jiang, X.-X., et al. (2005) Human Mesenchymal Stem Cells Inhibit Differentiation and Function of Monocyte-Derived Dendritic Cells. Blood, 105, 4120-4126.
https://doi.org/10.1182/blood-2004-02-0586
|
[105]
|
Melief, S.M., et al. (2013) Multipotent Stromal Cells Induce Human Regulatory T Cells through a Novel Pathway Involving Skewing of Monocytes toward Anti-Inflammatory Macrophages. Stem Cells, 31, 1980-1991.
https://doi.org/10.1002/stem.1432
|
[106]
|
Deng, Y., et al. (2016) Umbilical Cord-Derived Mesenchymal Stem Cells Instruct Monocytes towards an IL10-producing Phenotype by Secreting IL6 and HGF. Scientific Reports, 6, Article No. 37566. https://doi.org/10.1038/srep37566
|
[107]
|
Allavena, P., et al. (1998) IL-10 Prevents the Differentiation of Monocytes to Dendritic Cells but Promotes Their Maturation to Macrophages. European Journal of Immunology, 28, 359-369.
https://doi.org/10.1002/(SICI)1521-4141(199801)28:01<359::AID-IMMU359>3.0.CO;2-4
|
[108]
|
Liu, J., et al. (2020) Apoptotic Bodies Derived from Mesenchymal Stem Cells Promote Cutaneous Wound Healing via Regulating the Functions of Macrophages. Stem Cell Research & Therapy, 11, Article No. 507.
https://doi.org/10.1186/s13287-020-02014-w
|
[109]
|
Martínez-Aguilar, R., Romero-Pinedo, S., Ruiz-Magaña, M.J., Olivares, E.G., Ruiz-Ruiz, C. and Abadía-Molina, A.C. (2020) Menstrual Blood-Derived Stromal Cells Modulate Functional Properties of Mouse and Human Macrophages. Scientific Reports, 10, Article No. 21389. https://doi.org/10.1038/s41598-020-78423-x
|
[110]
|
Nguyen, H.-Q.-D., Kao, C.-Y., Chiang, C.-P., Hung, Y.-H. and Lo, C.-M. (2022) Investigating the Immunomodulatory Potential of Dental Pulp Stem Cell Cultured on Decellularized Bladder Hydrogel towards Macrophage Response in Vitro. Gels, 8, Article 187. https://doi.org/10.3390/gels8030187
|
[111]
|
Fathi, E., Farahzadi, R., Valipour, B. and Sanaat, Z. (2019) Cytokines Secreted from Bone Marrow Derived Mesenchymal Stem Cells Promote Apoptosis and Change Cell Cycle Distribution of K562 Cell Line as Clinical Agent in Cell Transplantation. PLOS ONE, 14, e0215678. https://doi.org/10.1371/journal.pone.0215678
|
[112]
|
Gu, Y., et al. (2015) Mesenchymal Stem Cells Suppress Neuronal Apoptosis and Decrease IL-10 Release via the TLR2/NFκB Pathway in Rats with Hypoxic-Ischemic Brain Damage. Molecular Brain, 8, Article No. 65.
https://doi.org/10.1186/s13041-015-0157-3
|
[113]
|
Ahmed, N.E.-M.B., Murakami, M., Hirose, Y. and Nakashima, M. (2016) Therapeutic Potential of Dental Pulp Stem Cell Secretome for Alzheimer’s Disease Treatment: An in Vitro Study. Stem Cells International, 2016, Article ID: 8102478.
https://doi.org/10.1155/2016/8102478
|
[114]
|
Ferlazzo, G. and Carrega, P. (2012) Natural Killer Cell Distribution and Trafficking in Human Tissues. Frontiers in Immunology, 3, Article 347.
https://doi.org/10.3389/fimmu.2012.00347
|
[115]
|
Paul, S. and Lal, G. (2017) The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy. Frontiers in Immunology, 8, Article 1124. https://doi.org/10.3389/fimmu.2017.01124
|
[116]
|
Giuliani, M., et al. (2011) Human Mesenchymal Stem Cells Derived from Induced Pluripotent Stem Cells Down-Regulate NK-Cell Cytolytic Machinery. Blood, 118, 3254-3262. https://doi.org/10.1182/blood-2010-12-325324
|
[117]
|
Reinders, M.E. and Hoogduijn, M.J. (2014) NK Cells and MSCs: Possible Implications for MSC Therapy in Renal Transplantation. Journal of Stem Cell Research & Therapy, 4, Article ID: 1000166.
|
[118]
|
Spaggiari, G.M., Capobianco, A., Abdelrazik, H., Becchetti, F., Mingari, M.C. and Moretta, L. (2008) Mesenchymal Stem Cells Inhibit Natural Killer-Cell Proliferation, Cytotoxicity, and Cytokine Production: Role of Indoleamine 2,3-Dioxygenase and Prostaglandin E2. Blood, 111, 1327-1333.
https://doi.org/10.1182/blood-2007-02-074997
|
[119]
|
Cui, R., et al. (2016) Human Mesenchymal Stromal/Stem Cells Acquire Immunostimulatory Capacity upon Cross-Talk with Natural Killer Cells and Might Improve the NK Cell Function of Immunocompromised Patients. Stem Cell Research & Therapy, 7, Article No. 88. https://doi.org/10.1186/s13287-016-0353-9
|
[120]
|
Sotiropoulou, P.A., Perez, S.A., Gritzapis, A.D., Baxevanis, C.N. and Papamichail, M. (2006) Interactions between Human Mesenchymal Stem Cells and Natural Killer Cells. Stem Cells, 24, 74-85. https://doi.org/10.1634/stemcells.2004-0359
|
[121]
|
Yan, F., et al. (2019) Human Dental Pulp Stem Cells Regulate Allogeneic NK Cells’ Function via Induction of Anti-Inflammatory Purinergic Signalling in Activated NK Cells. Cell Proliferation, 52, e12595. https://doi.org/10.1111/cpr.12595
|
[122]
|
Maucourant, C., et al. (2020) Natural Killer Cell Immunotypes Related to COVID-19 Disease Severity. Science Immunology, 5, eabd6832.
https://doi.org/10.1126/sciimmunol.abd6832
|
[123]
|
Bartholomew, A., et al. (2002) Mesenchymal Stem Cells Suppress Lymphocyte Proliferation in Vitro and Prolong Skin Graft Survival in Vivo. Experimental Hematology, 30, 42-48. https://doi.org/10.1016/S0301-472X(01)00769-X
|
[124]
|
Beyth, S., et al. (2005) Human Mesenchymal Stem Cells Alter Antigen-Presenting Cell Maturation and Induce T-Cell Unresponsiveness. Blood, 105, 2214-2219.
https://doi.org/10.1182/blood-2004-07-2921
|
[125]
|
Haddad, R. and Saldanha-Araujo, F. (2014) Mechanisms of T-Cell Immunosuppression by Mesenchymal Stromal Cells: What Do We Know So Far? BioMed Research International, 2014, Article ID: 216806. https://doi.org/10.1155/2014/216806
|
[126]
|
Laing, A.G., Fanelli, G., Ramirez-Valdez, A., Lechler, R.I., Lombardi, G. and Sharpe, P.T. (2019) Mesenchymal Stem Cells Inhibit T-Cell Function through Conserved Induction of Cellular Stress. PLOS ONE, 14, e0213170.
https://doi.org/10.1371/journal.pone.0213170
|
[127]
|
Najar, M., et al. (2009) Mesenchymal Stromal Cells Promote or Suppress the Proliferation of T Lymphocytes from Cord Blood and Peripheral Blood: The Importance of Low Cell Ratio and Role of Interleukin-6. Cytotherapy, 11, 570-583.
https://doi.org/10.1080/14653240903079377
|
[128]
|
Martin-Rufino, J.D., Espinosa-Lara, N., Osugui, L. and Sanchez-Guijo, F. (2019) Targeting the Immune System with Mesenchymal Stromal Cell-Derived Extracellular Vesicles: What Is the Cargo’s Mechanism of Action? Frontiers in Bioengineering and Biotechnology, 7, Article 308. https://doi.org/10.3389/fbioe.2019.00308
|
[129]
|
Wang, L., et al. (2021) Regulation of Inflammatory Cytokine Storms by Mesenchymal Stem Cells. Frontiers in Immunology, 12, Article ID: 726909.
https://doi.org/10.3389/fimmu.2021.726909
|
[130]
|
van Megen, K.M., van’t Wout, E.-J.T., Lages Motta, J., Dekker, B., Nikolic, T. and Roep, B.O. (2019) Activated Mesenchymal Stromal Cells Process and Present Antigens Regulating Adaptive Immunity. Frontiers in Immunology, 10, Article 694.
https://doi.org/10.3389/fimmu.2019.00694
|
[131]
|
Kyurkchiev, D., et al. (2014) Secretion of Immunoregulatory Cytokines by Mesenchymal Stem Cells. World Journal of Stem Cells, 6, 552-570.
https://doi.org/10.4252/wjsc.v6.i5.552
|
[132]
|
Moll, G., Hoogduijn, M.J. and Ankrum, J.A. (2020) Safety, Efficacy and Mechanisms of Action of Mesenchymal Stem Cell Therapies. Frontiers in Immunology, 11, Article 243. https://doi.org/10.3389/978-2-88963-600-6
|
[133]
|
Terraza-Aguirre, C., et al. (2020) Mechanisms behind the Immunoregulatory Dialogue between Mesenchymal Stem Cells and Th17 Cells. Cells, 9, Article 1660.
https://doi.org/10.3390/cells9071660
|
[134]
|
Tatara, R., et al. (2011) Mesenchymal Stromal Cells Inhibit Th17 but Not Regulatory T-Cell Differentiation. Cytotherapy, 13, 686-694.
https://doi.org/10.3109/14653249.2010.542456
|
[135]
|
Favaro, E., et al. (2016) Human Mesenchymal Stem Cells and Derived Extracellular Vesicles Induce Regulatory Dendritic Cells in Type 1 Diabetic Patients. Diabetologia, 59, 325-333. https://doi.org/10.1007/s00125-015-3808-0
|
[136]
|
Chen, Q.-H., et al. (2020) Mesenchymal Stem Cells Regulate the Th17/Treg Cell Balance Partly through Hepatocyte Growth Factor in Vitro. Stem Cell Research & Therapy, 11, Article No. 91. https://doi.org/10.1186/s13287-020-01612-y
|
[137]
|
de Cássia Noronha, N., et al. (2019) Priming Approaches to Improve the Efficacy of Mesenchymal Stromal Cell-Based Therapies. Stem Cell Research & Therapy, 10, Article No. 131. https://doi.org/10.1186/s13287-019-1224-y
|
[138]
|
Luk, F., et al. (2017) Inflammatory Conditions Dictate the Effect of Mesenchymal Stem or Stromal Cells on B Cell Function. Frontiers in Immunology, 8, Article 1042. https://doi.org/10.3389/fimmu.2017.01042
|
[139]
|
Luz-Crawford, P., et al. (2016) Mesenchymal Stem Cell-Derived Interleukin 1 Receptor Antagonist Promotes Macrophage Polarization and Inhibits B Cell Differentiation. Stem Cells, 34, 483-492. https://doi.org/10.1002/stem.2254
|
[140]
|
Corcione, A., et al. (2006) Human Mesenchymal Stem Cells Modulate B-Cell Functions. Blood, 107, 367-372. https://doi.org/10.1182/blood-2005-07-2657
|
[141]
|
Ding, G., Niu, J. and Liu, Y. (2015) Dental Pulp Stem Cells Suppress the Proliferation of Lymphocytes via Transforming Growth Factor-β1. Human Cell, 28, 81-90.
https://doi.org/10.1007/s13577-014-0106-y
|
[142]
|
Feng, Y., et al. (2020) Safety and Feasibility of Umbilical Cord Mesenchymal Stem Cells in Patients with COVID-19 Pneumonia: A Pilot Study. Cell Proliferation, 53, e12947. https://doi.org/10.1111/cpr.12947
|
[143]
|
Park, B.-W., et al. (2020) In Vivo Priming of Human Mesenchymal Stem Cells with Hepatocyte Growth Factor-Engineered Mesenchymal Stem Cells Promotes Therapeutic Potential for Cardiac Repair. Science Advances, 6, eaay6994.
https://doi.org/10.1126/sciadv.aay6994
|
[144]
|
Raza, S.S., Seth, P. and Khan, M.A. (2022) ‘Primed’ Mesenchymal Stem Cells: A Potential Novel Therapeutic for COVID19 Patients. Stem Cell Reviews and Reports, 17, 153-162. https://doi.org/10.1007/s12015-020-09999-0
|
[145]
|
Bustos, M.L., et al. (2013) Activation of Human Mesenchymal Stem Cells Impacts Their Therapeutic Abilities in Lung Injury by Increasing Interleukin (IL)-10 and IL-1RN Levels. STEM CELLS Translational Medicine, 2, 884-895.
https://doi.org/10.5966/sctm.2013-0033
|
[146]
|
Xu, A.L., et al. (2019) Mesenchymal Stem Cells Reconditioned in Their Own Serum Exhibit Augmented Therapeutic Properties in the Setting of Acute Respiratory Distress Syndrome. STEM CELLS Translational Medicine, 8, 1092-1106.
https://doi.org/10.1002/sctm.18-0236
|
[147]
|
Giunti, D., et al. (2021) Role of miRNAs Shuttled by Mesenchymal Stem Cell-Derived Small Extracellular Vesicles in Modulating Neuroinflammation. Scientific Reports, 11, Article No. 1740. https://doi.org/10.1038/s41598-021-81039-4
|
[148]
|
Öztürk, S., Elçin, A.E., Koca, A. and Elçin, Y.M. (2020) Therapeutic Applications of Stem Cells and Extracellular Vesicles in Emergency Care: Futuristic Perspectives. Stem Cell Reviews and Reports, 17, 390-410.
https://doi.org/10.1007/s12015-020-10029-2
|
[149]
|
Askenase, P.W. (2020) COVID-19 Therapy with Mesenchymal Stromal Cells (MSC) and Convalescent Plasma Must Consider Exosome Involvement: Do the Exosomes in Convalescent Plasma Antagonize the Weak Immune Antibodies? Journal of Extracellular Vesicles, 10, e12004. https://doi.org/10.1002/jev2.12004
|
[150]
|
Jayaramayya, K., et al. (2020) Immunomodulatory Effect of Mesenchymal Stem Cells and Mesenchymal Stem-Cell-Derived Exosomes for COVID-19 Treatment. BMB Reports, 53, 400-412. https://doi.org/10.5483/BMBRep.2020.53.8.121
|
[151]
|
Wiklander, O.P.B., Brennan, M.á., Lötvall, J., Breakefield, X.O. and El Andaloussi, S. (2019) Advances in Therapeutic Applications of Extracellular Vesicles. Science Translational Medicine, 11, aav852. https://doi.org/10.1126/scitranslmed.aav8521
|
[152]
|
Chung, M.-J., et al. (2020) Mesenchymal Stem Cell and MicroRNA Therapy of Musculoskeletal Diseases. International Journal of Stem Cells, 14, 150-167.
https://doi.org/10.15283/ijsc20167
|
[153]
|
Zayed, M. and Iohara, K. (2020) Immunomodulation and Regeneration Properties of Dental Pulp Stem Cells: A Potential Therapy to Treat Coronavirus Disease 2019. Cell Transplantation, 29. https://doi.org/10.1177/0963689720952089
|
[154]
|
Cui, S.J., et al. (2020) DPSCs Attenuate Experimental Progressive TMJ Arthritis by Inhibiting the STAT1 Pathway. Journal of Dental Research, 99, 446-455.
https://doi.org/10.1177/0022034520901710
|
[155]
|
Matsumura-Kawashima, M., Ogata, K., Moriyama, M., Murakami, Y., Kawado, T. and Nakamura, S. (2021) Secreted Factors from Dental Pulp Stem Cells Improve Sjögren’s Syndrome via Regulatory T Cell-Mediated Immunosuppression. Stem Cell Research & Therapy, 12, Article No. 182.
https://doi.org/10.1186/s13287-021-02236-6
|
[156]
|
Ogata, K., Matsumura-Kawashima, M., Moriyama, M., Kawado, T. and Nakamura, S. (2021) Dental Pulp-Derived Stem Cell-Conditioned Media Attenuates Secondary Sjögren’s Syndrome via Suppression of Inflammatory Cytokines in the Submandibular Glands. Regenerative Therapy, 16, 73-80.
https://doi.org/10.1016/j.reth.2021.01.006
|
[157]
|
Fujii, Y., et al. (2018) Bone Regeneration by Human Dental Pulp Stem Cells Using a Helioxanthin Derivative and Cell-Sheet Technology. Stem Cell Research & Therapy, 9, Article No. 24. https://doi.org/10.1186/s13287-018-0783-7
|
[158]
|
Lam, C., et al. (2021) Human Dental Pulp Stem Cells (DPSCs) Therapy in Rescuing Photoreceptors and Establishing a Sodium Iodate-Induced Retinal Degeneration Rat Model. Tissue Engineering and Regenerative Medicine, 18, 143-154.
https://doi.org/10.1007/s13770-020-00312-1
|
[159]
|
Zhang, Y., et al. (2021) DPSCs Treated by TGF-β1 Regulate Angiogenic Sprouting of Three-Dimensionally Co-Cultured HUVECs and DPSCs through VEGF-Ang-Tie2 Signaling. Stem Cell Research & Therapy, 12, Article No. 281.
https://doi.org/10.1186/s13287-021-02349-y
|
[160]
|
Hossein-Khannazer, N., Hashemi, S.M., Namaki, S., Ghanbarian, H., Sattari, M. and Khojasteh, A. (2019) Study of the Immunomodulatory Effects of Osteogenic Differentiated Human Dental Pulp Stem Cells. Life Sciences, 216, 111-118.
https://doi.org/10.1016/j.lfs.2018.11.040
|
[161]
|
Pierdomenico, L., et al. (2005) Multipotent Mesenchymal Stem Cells with Immunosuppressive Activity Can Be Easily Isolated from Dental Pulp. Transplantation, 80, 836-842. https://doi.org/10.1097/01.tp.0000173794.72151.88
|
[162]
|
Nakashima, M., Iohara, K. and Murakami, M. (2013) Dental Pulp Stem Cells and Regeneration. Endodontic Topics, 28, 38-50. https://doi.org/10.1111/etp.12027
|
[163]
|
Monsel, A., et al. (2022) Treatment of COVID-19-Associated ARDS with Mesenchymal Stromal Cells: A Multicenter Randomized Double-Blind Trial. Critical Care, 26, Article No. 48. https://doi.org/10.1186/s13054-022-03930-4
|
[164]
|
Peng, H., et al. (2020) A Synergistic Role of Convalescent Plasma and Mesenchymal Stem Cells in the Treatment of Severely Ill COVID-19 Patients: A Clinical Case Report. Stem Cell Research & Therapy, 11, Article No. 291.
https://doi.org/10.1186/s13287-020-01802-8
|
[165]
|
Guo, Z., Chen, Y., Luo, X., He, X., Zhang, Y. and Wang, J. (2020) Administration of Umbilical Cord Mesenchymal Stem Cells in Patients with Severe COVID-19 Pneumonia. Critical Care, 24, Article No. 420.
https://doi.org/10.1186/s13054-020-03142-8
|
[166]
|
Shi, L., et al. (2020) Treatment with Human Umbilical Cord-Derived Mesenchymal stem Cells for COVID-19 Patients with Lung Damage: A Randomised, Double-Blind, Placebo-Controlled Phase 2 Trial. medRxiv.
https://doi.org/10.1101/2020.10.15.20213553
|
[167]
|
Hashemian, S.-M.R., et al. (2021) Mesenchymal Stem Cells Derived from Perinatal Tissues for Treatment of Critically Ill COVID-19-Induced ARDS Patients: A Case Series. Stem Cell Research & Therapy, 12, Article No. 91.
https://doi.org/10.1186/s13287-021-02165-4
|
[168]
|
Häberle, H., et al. (2021) Mesenchymal Stem Cell Therapy for Severe COVID-19 ARDS. Journal of Intensive Care Medicine, 36, 681-688.
https://doi.org/10.1177/0885066621997365
|
[169]
|
Tao, J., et al. (2020) Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Treating a Critically Ill COVID-19 Patient. The Journal of Infection in Developing Countries, 14, 1138-1145. https://doi.org/10.3855/jidc.13081
|
[170]
|
Tang, L., et al. (2020) Clinical Study Using Mesenchymal Stem Cells for the Treatment of Patients with Severe COVID-19. Frontiers in Medicine, 14, 664-673.
https://doi.org/10.1007/s11684-020-0810-9
|
[171]
|
COVID-19 Treatment Guidelines. Clinical Spectrum of SARS-CoV-2 Infection.
https://www.covid19treatmentguidelines.nih.gov/overview/clinical-spectrum/
|