Prof. Atsushi Asakura
University of Minnesota, USA
Email: asakura@umn.edu
Qualifications
1993 Ph.D., University of Tokyo Graduate School, Molecular Biology
1987 M.Sc., Chiba University Graduate School, Biology
1984 B.Sc., Chiba University, Biology
Publications (Selected)
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A. Asakura, M. Kawamura. ATPase inhibitory activities found in the soluble fraction of an ascidian (Halocynthia rotezi) muscle.J. UOEH9: 29-33, 1987.
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A. Asakura, Y.-I. Nabeshima, K. Maruyama. In vitro synthesis of connectin in an extract of chicken embryo muscles. Zool. Sci.4,: 929-931, 1987.
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H. Sugita, I. Nonaka, Y. Itoh, A. Asakura, D. H. Hu, S. Kimura, K. Maruyama. Is nebulin the product of duchenne muscular dystrophy gene? Proc. Japan Acad. 63: 107-110, 1987.
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Fujisawa-Sehara, Y. Nabeshima, T. Komiya, T. Uetsuki, A. Asakura, Y. Hosoda, Y.-I. Nabeshima. Differential trans-activation of muscle-specific regulatory elements including the MLC box by chicken MyoD, myogenin, and MRF4.J. Biol. Chem. 267: 10031-10038, 1992.
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Y. Nabeshima, T. Uetsuki, T. Komiya, Y. Nabeshima, A. Asakura, K. Kamijo, T. Yagami, A. Fujisawa-Sehara. Positive and negative regulation in muscle. Symp. Soc. Exp. Biol. 46: 343-353, 1992.
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A. Asakura, A. Fujisawa-Sehara, T. Komiya, Y. Nabeshima, and Y.-I. Nabeshima. MyoD and myogenin act on the chicken myosin light chain 1 gene as distinct transcriptional factors. Mol. Cell. Biol. 13: 7153-7162, 1993.
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A. Asakura, G. E. Lyons, S. J. Tapscott. The regulation of myoD gene expression: Conserved elements mediated expression in embryonic axial muscle. Dev. Biol. 171, 386-398, 1995.
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M. B. McCormick, R M. Tamini, L. Snider, A. Asakura, D. Bergstrom, S. J. Tapscott. Neuro D2 and neuro D3: Distinct expression patterns and transcriptional activation potentials within the neuro D gene family. Mol. Cell. Biol.16:5792-5800, 1996.
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Kablar, K. Krastel, C. Ying, A. Asakura, S. J. Tapscott, M. A Rudnicki. MyoD and Myf-5 differentially regulate the development of limb versus trunk skeletal muscle. Development 124: 4729-4738, 1997.
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A. Asakura, S. J. Tapscott. Apoptosis of epaxial myotome in Danforth's short-tail (Sd) mice in somites that form following notochord degeneration.Dev. Biol. 203: 276-289, 1998.
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Kablar, A. Asakura, K. Krastel, C. Ying, L. L. May, S. J. Tapscott, D. Goldhamer, M. A. Rudnicki. MyoD and Myf-5 specify skeletal musculature in respect to their embryonic origin.Biochem. Cell. Biol. 76: 1079-1091, 1999.
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L. A. Sabourin, A. Girgis-Gabardo, P. Seal, A. Asakura, M. A. Rudnicki. Reduced differentiation potential of primary MyoD-/- myogenic cells derived from adult skeletal muscle.J. Cell. Biol. 144: 631-643, 1999.
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J. M. Olson*, A. Asakura*, L. Snider, R. Hawkes, A. Strand, S. J. Tapscott, NeuroD2 is necessary for normal development and survival of central nervous system neurons. Dev. Biol. 238: 174-187, 2001. (*These authors contributed equally)
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A. Asakura, M. Komaki, M. A. Rudnicki. Muscle satellite cells are multipotential stem cells that exhibit myogenic, osteogenic, and adipogenic differentiation. Differentiation 68: 245-253, 2001.
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A. Asakura, M. A. Rudnicki. Side population cells from diverse adult tissues are capable of in vitro hematopoietic differentiation. Exp. Hematol. 30: 1339-1345, 2002.
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A. Asakura, P. Seale, A. Girgis-Gabardo, M. A. Rudnicki. Myogenic specification of side population cells in skeletal muscle. J. Cell Biol. 159, 123-134, 2002.
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M. Komaki, A. Asakura, M. A. Rudnicki, S. Cheifetz, J. Sodek. MyoD enhances BMP-induced osteogenic differentiation of myogenic cell cultures. J Cell Sci. 117: 1457-68, 2004.
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C. J. Storbeck, K. Daniel, Y. H. Zhang, J. Lunde, A. Scime,A. Asakura, B. Jasmin, R. G. Korneluk, L. A. Sabourin. Ste20-like kinase SLK displays myofiber type specificity and is involved in C2C12 myoblast differentiation. Muscle Nerve 29: 553-64, 2004.
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J. Ishibashi, R. L. Perry,A. Asakura, M. A. Rudnicki, MyoD induces myogenic differentiation through cooperation of its NH2- and COOH-terminal regions.J. Cell Biol. 171: 471-482, 2005.
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Y. Nakamura, X. Wang, C. Xu,A. Asakura, M. Yoshiyama, A. H. From, J. Zhang. Xenotransplantation of Long Term Cultured Swine Bone Marrow-Derived Mesenchymal Stem Cells.Stem Cells. 25I6: 12-20, 2007.
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G. Grenier, A. Scimè, F. Legrand, A. Asakura, C.Perez-Iratxeta, M. A.Andrade-Navarro, P. A.Labosky, M. A.Rudnicki. Resident Endothelial Precursors in Muscle, Adipose and Dermis Contribute to Post-Natal Vasculogenesis.Stem Cells. 25 (12): 3101-3110, 2007.
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A. Asakura*, H. Hirai, B. Kablar, S. Morita, J. Ishibashi, B. A. Piras, A. J. Christ, M. Verma,K. A. Vineretsky, M. A. Rudnicki. Increased survival ofmuscle stem cellslacking the Myo Dgene after transplantation into regenerating skeletal muscle. Proc Natl Acad Sci U S A.104:16552-16557, 2007. (*Corresponding author) Selected for Faculty of 1000.
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H. Hirai, L. Romanova, S. Kellner, M. Verma, S. Rayner, A. Asakura*, N. Kikyo*. Post-mitotic role of nucleostemin as a promoter of skeletal muscle cell differentiation.Biochem. Biophys. Res. Commun. 39: 299-304, 2010. (*Double corresponding authors)
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M. Verma, Y. Asakura, H. Hirai, S. Watanabe, C. Tastad, G.-H. Fong,M. Ema, J. A. Call, D. A. Lowe, A. Asakura*. Flt-1haploinsufficiency ameliorates muscular dystrophy phenotype by developmentally increased vasculature inmdxmice.Hum. Mol. Genet. 19 (21): 4145-4159, 2010. (*Corresponding author)
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H. Hirai, M. Verma, S. Watanabe, C. Tastad, Y. Asakura, A. Asakura*.MyoD Regulates apoptosis of myoblasts through micro RNA-mediated down-regulation of Pax3. J. Cell Biol. 191 (2): 347-365, 2010. (*Corresponding author)
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M. Verma, A. Asakura*. Efficient single muscle fiber isolation from alcohol fixed adult muscle following beta-galactosidase staining for satellite cell detection. J. Histochem. Cytochem. 59: 60-67, 2011. (*Corresponding author)
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S. Watanabe, H. Hirai, Y. Asakura, C. Tastad, M. Verma, C. Keller, J. R. Dutton, A. Asakura*. MyoDgene suppression by Oct4 is required for reprogramming in myoblasts to produce induced pluripotent stem cells.Stem Cells. 29: 505-516, 2011.
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J.-H. Kim, W. S. Torgerud, K. H. H. Mosser, H. Hirai, S. Watanabe, A. Asakura, and L. V. Thompson.Myosin light chain 3f attenuates age-induced decline incontractile velocity in MHC type II single muscle fibers.Aging Cell. 11(2): 203-12, 2012.
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Y. Wen, P. Bi, W. Liu,A. Asakura, C. Keller, S. Kuang. Constitutive Notch activation upregulates Pax7 and promotes the self-renewal of skeletalmusclesatellite cells. Mol Cell Biol. 2012. [Epub ahead of print]
Last Updated: August, 2012