Article citationsMore>>
V. Galimberti, B. F. Cole, S. Zurrida, G. Viale, A. Luini, P. Veronesi, P. Baratella, C. Chifu, M. Sargenti, M. Intra, O. Gentilini, M. G. Mastropasqua, G. Mazzarol, S. Massarut, J. R. Garbay, J. Zgajnar, H. Galatius, A. Recalcati, D. Littlejohn, M. Bamert, M. Colleoni, K. N. Price, M. M. Regan, A. Goldhirsch, A. S. Coates, R. D. Gelber and U. Veronesi, “International Breast Cancer Study Group Trial 23-01 Investigators, “Axillary Dissection versus No Axillary Dissection in Patients with Sentinel-Node Micrometastases (IBCSG 23-01): A Phase 3 Randomised Controlled Trial,” Lancet Oncology, Vol. 14, No. 4, 2013, pp. 297-305. doi:10.1016/S1470-2045(13)70035-4
has been cited by the following article:
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TITLE:
The Association between Sentinel Lymph Node Metastasis and Ki-67 Labeling Index
AUTHORS:
Yu Koyama, Hiroshi Ichikawa, Jun Sakata, Eiko Sakata, Kumiko Tatsuda, Miki Hasegawa, Chie Toshikawa, Naoko Manba, Mayuko Ikarashi, Toshifumi Wakai
KEYWORDS:
Breast Cancer; Sentinel Lymph Node; Molecular Subtypes; Ki-67 Labeling Index
JOURNAL NAME:
Advances in Breast Cancer Research,
Vol.2 No.3,
June
24,
2013
ABSTRACT:
Background: The purpose of this study was to elucidate the
association between sentinel lymph node (SLN) metastasis and Ki67 labeling
index and to elucidate whether Ki-67 was useful or not for prediction of SLN
metastasis in breast cancer. Methods: We identified 343 invasive breast cancer
patients with sentinel lymph node biopsy (SLNB) from 2003 to 2012. The
association between SLN status and clinicopathological features, molecular
subtypes and Ki-67 labeling index were evaluated. Results: SLN metastasis was
detected in 79 patients (23.0%). SLN metastasis was significantly associated
with clinical T-stage (p = 0.0003), lymphovascular involvement (LVI) (p 0.0001).
Ki-67 labeling index of primary tumor was significantly lower in SLN positive
patients (p = 0.0331), and Ki-67 cut-off point of 7.5% was useful for
dividing SLN positive from negative (p = 0.0197). Conclusion: Low value of
Ki-67 labeling index, in addition to progression of clinical T-stage and
presence of LVI, is significantly associated with SLN metastasis, and it seems
to be useful to consider Ki-67 labeling index for SLN metastasis prediction.
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