Dr. Jing Zheng
Department of Otolaryngology-Head and Neck Surgery, Feinberg School of Medicine
Northwestern University, USA
Associate Professor
Email: jzh215@northwestern.edu
Qualifications
1992 Ph.D., Physiology, Michigan State University,
USA
1985 M.Sc, Virology, Wuhan University, China
1982 B.Sc., Biology, Wuhan University, China
Publications (Selected)
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Zheng, J., Furness, D., Duan, C.,
Miller, K.K., Edge, R.M., Chen, J., Homma, K., Hackney,C.M., Dallos, P., and
Cheatham, M.A. Marshalin, a microtubule minus-end binding protein, regulates
cytoskeletal structure in the organ of Corti.Biology Open.
2(11) 1192-1202 (2013). PMCID: PMC3828766
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Wong PC, Morgan-Short K, Ettlinger M, Zheng
J.,
Linking neurogenetics and individual differences in language learning: The
dopamine hypothesis. Cortex. 2012 48 (9):1091-1102. PMID: 22565204
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Wong, C.M. P., Ettlinger, M., Zheng, J. Linguistic
Grammar Learning and DRD2 TAQ-IA Polymorphism. PLoS One. 2013 May
31;8(5):e64983. PMID: 23741438
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Homma, K., Duan, C., Zheng J., Cheatham, MA.,
Dallos P. Impairment of prestin’s fast motor kinetics by the V499G/Y501H
mutation and its significance for defining functional independence of
individual prestin subunits. J Biol Chem. (2013);288(4):2452-2463. doi: 10.1074/jbc.M112.411579.
PubMed PMID: 23212912.
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Cheatham, MA., Homma, K., Zheng J., Dallos P,
What can prestin mouse models tell us about cochlear amplification? 2012, Proc.
Auditory Res. Meeting, The Acoustical Society of Japan, Vol. 41
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Wong, C.M. P., Chandrasekaran, B., Zheng, J. The
Derived Allele of ASPM is Associated with Lexical Tone Perception. PloS One. 2012.
7 (4):e34243.
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Zheng, J., Miller KK, Yang T, Hildebrand MS,
Shearer AE, DeLuca AP, Scheetz TE,Drummond J, Scherer SE, Legan PK, Goodyear
RJ, Richardson GP, Cheatham MA, Smith RJH, Dallos P. Carcinoembryonic
antigen-related cell-cell adhesion molecule 16 interacts with α−tectorin and is mutated in autosomal dominant
hearing loss (DFNA4). PNAS. 2011. Mar 8;108(10):4218-23.
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Zheng L, Zheng J, Whitlon DS, García-Añoveros
J, Bartles JR. Targeting of the hair cell proteins cadherin 23, harmonin,
myosin XVa, espin, and prestin in an epithelial cell model. J Neurosci. 2010
May 26;30(21):7187-201.
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Sengupta S, Miller KK, Homma K, Edge R,
Cheatham MA, Dallos P, Zheng J. Interaction between the motor protein prestin
and the transporter protein VAPA. Biochim Biophys Acta-Molecular Cell Research.
2010 Jul;1803(7):796-804. PMC2878928.
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Homma
K, Miller KK, Anderson CT, Sengupta S, Du GG, Aguiñaga S, Cheatham M, Dallos P,
Zheng J. Interaction between CFTR and prestin (SLC26A5). Biochim Biophys Acta-Biomembranes.
2010 Jun;1798(6):1029-40. PMC2862844.
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Cheatham,
MA., Low-Zeddies, S., Naik, K., Edge, R., Zheng, J., Anderson CT., Dallos, P.,A
Chimera Analysis of Prestin knock-out Mice. J. Neurosci., 29(38):12000-12008.,
2009.
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Sengupta,
S., George, M., Miller, KK., Naik, K., Chou, J., Cheatham, MA., Dallos, P., Naramura.
M., Band, H., Zheng, J., EHD4 is an interacting partner for inner ear hair cell
tiplink protein CDH23. J Biol Chem. 284(30):20121-9, 2009.
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Zheng
J, Anderson CT., Miller, KK., Cheatham, MA., Dallos, P., Identifying components
of the hair-cell interactome involved in cochlear amplification BMC Genomics 10:127,
2009.
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Dallos,
P., Wu, X., Cheatham, MA., Gao, J., Zheng, J., Anderson, CT., Jia, S., Wang,
X.,Cheng, HYW., Sengupta, S., He, DZZ., Zuo, J., Prestin-based outer hair cell
motility is necessary for mammalian cochlear amplification. Neuron, May 8;58
(3):333-9, 2008.
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Wu,
X., Wang, X., Gao, J., Yu, Y., Jai, S., Zheng, J., Dallos, P., He, DZZ,
Cheatham, MA.,Zuo, J., Glucose transporter 5 is not required for outer hair
cell electromotility and cochlear amplification. Brain Research May 19;1210
:20-8, 2008.
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Gao J,
Wang X, Wu X, Aguinaga S, Huynh K, Jia S, Matsuda K, Patel M, Zheng J, Cheatham
M, He DZ, Dallos P, Zuo J., Prestin-based outer hair cell electromotility in knockin
mice does not appear to adjust the operating point of a cilia-based amplifier. Proc
Natl Acad Sci U S A, 30: 12542-12547, 2007.
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Cheatham,
M.A., Zheng, J., Huynh, K.H., Du, GG., Edge, R.M., Anderson, C.T., Zuo, J.,Ryan,
A.F. and Dallos, P., Evaluation of an independent prestin mouse model derived
from the 129S1 strain Audiology & Neurotology 12(6):378-90, 2007.
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Tóth,
T., Deák, L., Fazakas, F., Zheng, J., Muszbek, L. and Sziklai, I. A new
mutation in the human pres gene and its effect on prestin function. International
Journal of Molecular medicine, 20:545-550, 2007.
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Anderson
CT., Zheng J., Isolation of outer hair cells from the cochlear sensory
epithelium in whole-mount preparation using laser capture microdissection. J
Neurosci Methods, 162: 229-236, 2007.
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Dallos
P, Zheng J, Cheatham MA., “Prestin and the cochlear amplifier.” J Physiol.,
1;576 (Pt 1):37-42, 2006.
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He,
D.Z.Z., Zheng, J., Kalinec, F., Kakehata, S., Santos-Sacchi J., Tuning in to
the amazing outer hair cell: membrane wizardry with a twist and shout. J.
Membrane Biol., 209: 119-34,2006.
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Zheng
J, Du GG, Anderson CT, Keller JP, Orem A, Dallos P, Cheatham M.“Analysis of the
oligomeric structure of the motor protein prestin.” J Biol Chem., 281(29):19916-24.,
2006