Complete Fusion of the Maxillamandibular: Report of a Rare Case and Review of the Literature (Short Report)
1. Introduction
The maxillomandibular fusion is a condition characterized by the presence of adhesions of osseous tissue and/or soft tissue between the mandible and maxilla. This condition may be congenital or acquired, isolated or associated with other abnormalities (temporomandibular ankylosis of the mandibular joint, cleft lip and palate, Van der Woude syndrome, etc.) [1] . Through this clinical case, we report diagnostic modalities of this rare disease, treatment difficulties (surgical and anaesthetic) and the action to be taken aiming at reducing the incidence of recurrence.
2. Case Report
E. Meriem is a 2-year-old infant admitted to the Plastic Surgery Service in university Hospital for a cleft lip and palate (CLP). The girl is an only child and there are no similar cases in the family. At the age of 7 months, she was hospitalized in another hospital to remedy the CLP but the occurrence of cardiac arrest at the anaesthetic induction, due to the impossibility of intubation, has discouraged the pursuance of the intervention.
At admission, clinical examination reveals a significant limitation of mouth opening with a 0.5-cm mandible, a CLP with fistulas of the lower lip including a Van der Woude syndrome. An X-ray CT highlighted the CLP but has provided no explanation for the limited opening of the mouth. The decision was made to remedy the cleft lip and perform an intraoral examination under anaesthesia. Indeed, it revealed the presence of bilateral maxillomandibular gingival adhesions explaining the mouth opening limitation. A section of these adhesions exposed a 2-cm mandible, which was maintained by the immediate postoperative establishment of a callus. Currently, 4 years later, the initial result was maintained through a regular physiotherapy follow-up (Figure 1).
3. Discussion
The maxillomandibular fusion is an extremely rare condition. A review of the literature is difficult because of the variety of classifications: “Congenital fusion of jaws”, “Temporo Mandibular Joints Pseudoankylosis and even agnathia”... In 1936, Burket [2] reported the first case of “maxillomandibularsyngnathia” in a patient who also manifested a Temporo Mandibular Joints (TMJ) Pseudoankylosis, a gum fusion and a hemi-facial atrophy.
In 2001, Laster et al. [3] stated 24 cases described in the literature. Hegab reported the last cases in 2012 [4] . Hence, forty reported cases.
The causes of congenital syngnathia are not well defined. Some have suggested a persistent oropharyngeal membrane, a constriction by amniotic bands in the area of the development of the first gill arch, violence, and the use of drugs such as high doses of vitamin A during pregnancy [5] . The diagnosis is made when the affected newborns develop respiratory difficulties, then nutrition difficulties, and it is the mouth opening limitation, which is the telltale sign. X-ray or CT can confirm the diagnosis when the fusion affects the bone. An MRI may be indicated when the fusion affects soft tissues. CT imaging gives more information and detects any skeletal dysmorphia [4] [5] .
It is difficult to standardize the treatment because the disease is rare, and it is often part of a malformation syndrome [6] - [8] . In all cases, early treatment is essential. A long-term immobilisation would lead to the risk of ankylosis of Temporo Mandibular Joints, making a surgical treatment more complicated [9] . Early surgical release of adhesions is recommended to ensure a normal diet, prevent obstruction of the upper airway, allow normal mandibular function and ensure proper growth [9] . Early intervention is also important to reduce the risk of ankylosis of the ascending rami of mandible to the maxilla and zygomatic complex.
General anesthesia is often difficult. As in the first case where the infant presented problems during the induction that may be probably related to oesophageal intubation. Fiber optic laryngoscopes are required for endotracheal intubation, with careful handling because of the fragility of the mandibular bone with the risk of fracture [10] . Recurrence is a matter of course, along with the need for more interventions. Early, intense and regular physiotherapy follow up reduces this risk. However, it is difficult to establish especially in young patients.
4. Conclusions
The maxillomandibular fusion is a rare condition; however, the diagnosis must be carried out after the observation of respiration and nutrition difficulties in newborns, or a mouth opening limitation at an older age. CT or MRI then confirms the diagnosis.
Surgery and anesthesia are subtle and require a knowledgeable team. Early treatment is essential to limit the risk of ankylosis, and early intense and regular physiotherapy treatment reduces the risk of recurrence.
NOTES
*Corresponding author.