Prof. Sylvain
ROUTIER
Institut de
Chimie Organique et Analytique ( ICOA)
University of
Orléans, France
E-mail: sylvain.routier@univ-orleans.fr
Qualifications
1998 Post-doctoral
position: UCB Pharma (Belgium)
1996 PhD
Thesis, University of Lille 1 (UMR-CNRS)
1995 Master
degree in Drug Design, University of Lille 2. Supplementary formation
Publications
(Selected)
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Potassium
indol-2-yl trifluoroborate as efficient building block in palladium-catalyzed
Suzuki-Miyaura cross-coupling, P. Kassis, V., Bénéteau, J.Y. Mérour, S.
Routier. Synthesis, 2009, 19, 2447-2453.
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Efficient
Synthesis of 2-Substituted Pyrido[3,2-d]pyrimidines Involving SNAr and
Palladium Cross Coupling Reactions, A. Tikad, S. Routier, M. Akssira, J.M.
Léger, C. Jarry, G. Guillaumet, Synthesis, 2009, 14, 2379-2384.
-
New Efficient
Access to Fused AryltetrahydroIndolizinones via N-Acyliminium Intermediates. M.
Chiurato, S. Routier, Y. Troin, G. Guillaumet Eur J. Org.Chem. 2009, 18,
3011-3021.
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First
efficient palladium-catalyzed aminations of pyrimidines, 1,2,4-triazines and
tetrazines by original methyl sulfur release Pellegatti, L. ; Vedrenne, E. ;
Leger, J. M. ; Jarry, C. ; Routier, S. Synlett 2009, 13, 2137-2142.
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Efficient
one-pot synthesis of 2,4-di(het)aryl and 2,4-diaminopyrido[3,2-d]pyrimidines
involving regioselective SNAr and palladium-catalyzed reactions
Tikad, A.; Routier, S.; Akssira, M.; Guillaumet, G. Org. Biomol.
Chem., 2009, 7, 5113–5118.
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Convenient
access to C-2 or C-5 substituted 4-azaindole derivatives. Saab F.,
Bénéteau V., Schoentgen F., Mérour J-Y., Routier S. Tetrahedron, 2010, 66,
102-10.
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Animal Bone
Meal (ABM): A Novel Natural Catalyst for Thia-Michael Addition Riadi, Y.;
Mamouni, R.; Abrouki, Y.; El Haddad, M.; Saffaj, S. El Antri, N.;Routier,
S. ; Guillaumet, G.; Lazar, S., Lett. Org. Chem, 2010, 269-271.
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Benzoxazine
and Benzodioxine as Indole Isosteres in Indolocarbazoles Series: Synthesis and
Biological Evaluation Ayerbe, N.; Routier, S.; Gillaizeau, I.;
Tardy, S.; Coudert, G. Lett. Org. Chem., 2010, 7, 121-126.
-
Comparison of
the efficiencies of two TR-FRET methods to detect /in vitro/ natural and
synthesized inhibitors of the Raf/MEK/ERK signalling pathway Saab, F.; Routier,
S.; Bénéteau, V.; Mérour J.Y.; Schoentgen F. Int. J. High Throughput
Screening". 2010, 1, 81-98.
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Efficient
Synthesis of the First N-Methyloxoarcyriaflavin Including an Original Central
Seven-Membered Cycle A. Bourderioux; A. Ouach; V. Bénéteau; J.-Y. Mérour;
S. Routier Synthesis 2010, 783–790.x.
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New efficient
Access to Fused (Het)Aryltetrahydroindolizinones via N-Acyl Iminium
Intermediates. M. Chiurato, R. Boulahjar, S. Routier, Y. Troin, G.
Guillaumet Tetrahedron, 2010, 66, 4647-4653.
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New
HeteroAromatic Aminations on 5-Aryl-1,2,4-Triazines and 1,2,4,5-Tetrazines by
Palladium Catalysis L. Pellegatti, E. Vedrenne, J.-M. Leger,C. Jarry, S.
Routier, Tetrahedron, 2010, 66, 4383-4389.
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Animal bone
meal as an afficient catalyst for crossed-aldol condensation. Riadi, Y. ;
Mamouni, R. ; Azzalou, R. ; Boulahjar, R. ; Abrouki, Y. ; El Haddad, M. ;
Routier, S. ; Guillaumet, G. ; Lazar, S. Tetrahedron Lett. 2010, 51,
6715-6717.
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Synthesis and
biological evaluation of novel benzodioxinocarbazoles (BDCZs) as potential
anticancer agents. Ayerbe, N. ; Routier, S. ; Gillaizeau, I. ; Maiereanu,
C. ; Caignard, D. H. ; Pierré, A. ; Léonce, S. ; Coudert, G. Bioorg. Med.
Chem. Lett. 2010, 20, 4670-4674.
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Synthesis and
biological activities of new furo[3,4-b]carbazoles: Potential topoisomerase II
inhibitors. Hajbi, Y. ; Néagoie, C. ; Biannic, B. ; Chilloux, A. ;
Vedrenne, E. ; Baldeyrou, B. ; Bailly, C. ; Mérour, J. Y. ; Rosca, S. ;
Routier, S. ; Lansiaux, A. Eur. J. Med. Chem. 2010, 45, 5428-5437.
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Efficient
pallado-catalyzed C6-(het)arylation of imidazo[1,2-b][1,2,4,5]tetrazines under
microwave irradiations. Pellegatti, L. ; Vedrenne, E. ; Leger, J. M. ; Jarry,
C. ; Routier, S. J. Comb. Chem. 2010, 12, 604-608.
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Efficient
synthesis of 2,4-disubstituted pyrido [3,2-d]pyrimidines involving SNAr and
Suzuki-Miyaura cross coupling reactions. Tikad, A. ; Routier, S. ;
Akssira, M. ; Guillaumet, G. J. Mar. Chim. Het. 2010, 9, 1-8.