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has been cited by the following article:

• TITLE: Synthesis and in Vitro Cytotoxic Activity of Novel Pyrazole-3,4-dicarboxylates

  AUTHORS: Hanan Sekkak, El Mostapha Rakib, Medaghri-Alaoui Abdelouahid, Abderrafia Hafid, Abdelghani El Malki

  KEYWORDS: Nitrile Imines; Cycloaddition; Pyrazoles; Cytotoxic Activity

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.3 No.1, March 22, 2013

  ABSTRACT: N-Aryl-C-ethoxycarbonylnitrile imines (3a-g) react with ethyl cyanoacetate 1 in 1,3-dipolar cycloaddition to yield novel pyrazole-3,4-dicarboxylates (4a-g) in moderate yields. The reaction of pyrazole-3,4-dicarboxylates (4a, d) with hydrazine afforded pyrazolo[4,3-d]pyridazine-4,7-diones (5a, d) in good yields. All compounds were fully characterized by spectroscopic methods. Some of the newly synthesized compounds were evaluated for their cytotoxic activity against murine P815 mastocytoma cell line.