TITLE:
Determination of Meclofenoxate Content in Meclofenoxate Hydrochloride for Injection by DSC and 1H-NMR
AUTHORS:
Peipei Zhang, Tingting Liu, Xuejiao Xu, Shuyu Liu, Dongying Chen
KEYWORDS:
Meclofenoxate Hydrochloride, DSC, 1H-NMR, Analysis
JOURNAL NAME:
American Journal of Analytical Chemistry,
Vol.7 No.1,
January
25,
2016
ABSTRACT: Two simple and rapid analytical methods (DSC and 1H-NMR), are
proposed for determination of meclofenoxate in meclofenoxate hydrochloride for
injection. DSC thermogram is recorded without any sample pretreatment. The
response linearity is ensured by linear determination factors R2,
which is 0.9982. The recoveries of meclofenoxate hydrochloride in sterile
powder for injection are from 98.3% to 102.3% (n = 3). The quantitative 1H-NMR
is quick and simple to use. The quantitation of meclofenoxate is reproducible
and the relative standard deviation is 1.0%. The accuracy of two methods is
validated by comparison with the results obtained by HPLC. The results show
that the two methods are capable of quantifying the content of meclofenoxate in
meclofenoxate hydrochloride for injection.