TITLE:
Combination of the MODS Assay with the SensititreTM MYCOTB Plate for Rapid Detection of MDR- and XDR-TB
AUTHORS:
Parichat Salee, La’Chia Harrison, Kim Dionne, Carole McArthur, Nicole Parrish
KEYWORDS:
Tuberculosis, Susceptibility Testing, MODS, MYCOTB, MDR-TB, XDR-TB
JOURNAL NAME:
Journal of Tuberculosis Research,
Vol.2 No.3,
September
3,
2014
ABSTRACT: We combined the new SensititreTM MYCOTB test with the MODS assay for detection of MDR- and XDR-TB. Categorical agreement of the MODS assay with the critical concentrations at 3 days of incubation was highest for INH (91.4%) and RIF (100%) and at 5 days 86.7% and 94.6% for the fluoroquinolones and aminoglycosides, respectively. By combining these two methods, it is possible to identify MDR-TB in as little as 3 days and XDR- or pre-XDR-TB within 5 days.