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Wilson, A.P. (2000) Cytotoxicity and Viability Assays in Animal Cell Culture: A Practical Approach. 3rd Edition, Oxford University Press, Oxford.

has been cited by the following article:

  • TITLE: New Square-Pyramidal Oxovanadium (IV) Complexes Derived from Polydentate Ligand (L1)

    AUTHORS: Azza A. Hassoon, Najlaa S. Al-Radadi, Nagwa Nawar, Mohsen M. Mostafa

    KEYWORDS: Oxovanadium (IV) Complexes, Antimicrobial Activity, Cytotoxic Activity, Breast Cancer

    JOURNAL NAME: Open Journal of Inorganic Chemistry, Vol.6 No.1, January 15, 2016

    ABSTRACT: New series of oxovanadium (IV) complexes isolated from 2,4,6-tris-(2-pyridyl)-1,3,5-triazine (L1) are incorporated and portrayed using spectroscopic (IR, UV-Vis, ESR, mass spectrometric), magnetic moment, thermal and cyclic voltammetry measurements. The results demonstrate that L1 acts in various styles of chelation with [V3O3(L1)(SO4)3(EtOH)1/2(H2O)3/2] 1), [VO(L1)(2,4-pentadionate)]·Cl·4HCl 2), [V2O2(L1)(SO4)2(EtOH)5/2] 3), [V2O2(L1)(SO4)2(EtOH)3/2(H2O)1/2] 4), [VO(L1)SO4 (H2O)3/2]·2.5H2O 5) and [V2O2(L1)(SO4)2(H2O)]·H2O 6). The values of magnetic moments and spectral studies suggest a square-pyramidal geometry around the V (IV) ion for all complexes. The molar conductance values suggest that the complexes are non-electrolyte, except the [VO(L1) (2,4-pentadionate)] Cl·4HCl. Molecular modeling calculates the bond length, bond angle, chemical reactivity, energy components (Kcal/mol) and binding energy (Kcal/mol) for the isolated complexes. The in vitro antibacterial studies of these complexes screened against pathogenic bacteria prove them as growth inhibiting agents. Antitumor activity is carried out in vitro on human mammary gland (breast) MCF-7 and cervical cancer cell-HeLa has shown that [VO(L1)SO4(H2O)3/2]·2.5 H2O and [VO(L1)(2,4-pentadionate)] Cl·4HCl complexes display the highest powerful activity between all of the investigated complexes.