Evaluation of Antioxidant and Cytotoxic Capacity of Croton bonplandianum. Baill

Muhammad Naeem Qaisar, Bashir Ahmad Chaudary, Muhammad Uzair, Sajid Nawaz Hussain

Faculty of Pharmacy, Bahauddun Zakariya University, Multan, Pakistan..

DOI: 10.4236/ajps.2013.49208                

Abstract

The antioxidant and cytotoxic activities of Methanolic and Dichloromethane extracts of Croton bonplandianum Baill were evaluated in a bid to provide better scientific basis for the isolation of bioactive compounds from the plant. The DPPH and hydroxyl radical scavenging activities of the Methanolic extract were 59.62%, and Dichloromethane extract was not toxic. Gallic acid used as reference compounds showed higher antioxidant activities to the plant extracts. Both methanolic and dichloromethane extracts were evaluated for their brine shrimp lethality. Methanolic extract showed cytotoxic activity in vitro with a LD₅₀ value of 115.76 (0.0048-3.76) μg/ml. Etoposide was used as standard drug. Put together, these results confirm that Croton bonplandianum extracts possess appreciable natural antioxidant and cytotoxic potentials, thereby providing good justification for the isolation of pure bioactive compounds.

Keywords

Antioxidant Activity; Scavenging Activity; Cytotoxic Activity; Brine Shrimp; Croton bonplandianum

Conflicts of Interest

The authors declare no conflicts of interest.

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