Dr. Kamil
Kuka
University of
Defense, Czech Republic
Email: kucakam@pmfhk.cz
Qualifications
2005 Ph.D.,
University of Defense
2001 M.Sc.,
Institute of Chemical Technology
Publications (selected)
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Kim T.H., Kuca
K., Jun D, Jung Y.S.: Design and synthesis of new bis-pyridinium oximes as
cyclosarin-inhibited acetylcholinesterase reactivators. Bioorganic Medicinal
& Chemistry Letters. 2005, 15, 2914-2917.
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Kuca K., Jun
D., Musilek K.: Structural requirements of acetylcholinesterase reactivators.
Mini Reviews in Medicinal Chemistry. 2006, 6(3), 269-277.
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Musilek K.;
Kuca K; Jun D.; Dolezal M.: Progress in synthesis of new acetylcholinesterase
reactivators during the period 1990-2004. Current Organic Chemistry. 2007,
11(2), 229-238.
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Bajgar J.,
Fusek J., Kuca K., Bartosova L., Jun D.: Treatment of organophosphate
intoxication using cholinesterase reactivators: facts and fiction. Mini Reviews
in Medicinal Chemistry. 2007, 7(5), 461-466
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Kuca K., Jun
D., Bajgar J. Structural factors influencing potency of currently used
acetylcholinesterase reactivators for treatment of cyclosarin intoxications.
Current Pharmaceutical Design. 2007, 13(33), 3445-3452.
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Musilek K.,
Holas O., Jun D., Dohnal V., Gunn-Moore F., Opletalova V., Dolezal M., Kuca K.:
Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker –
Preparation and reactivation of tabun and paraoxon-inhibited
acetylcholinesterase. Biorganic & Medicinal Chemistry. 2007; 15, 6733-6741.
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Musilek K.,
Jun D., Cabal J., Kassa J., Gunn-Moore F., Kuca K.: Design of a Potent
Reactivator of Tabun-Inhibited Acetylcholinesterase - Synthesis and evaluation
of (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene
Dibromide (K203), Journal of Medicinal Chemistry. 2007, 50(22), 5514-5518.
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Patocka J.,
Jun D., Kuca K.: Possible Role of Hydroxylated Metabolites of Tacrine in Drug
Toxicity and Therapy of Alzheimer´s Disease. Current Drug Metabolism. 2007,
9(4), 332-335.
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Kassa J.,
Karasova J., Musilek K., Kuca K.: An evaluation of therapeutic and reactivating
effects of newly developed oximes (K156, K203) and commonly used
oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.
Toxicology. 2008, 243 (3), 311-316.
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Oh KA., Park
NJ., Park NS., Kuca K., Jun D., Jung YS.: Determination of reactivation potency
for DFP- and Paraoxon-Inhibited Acetylcholinesterases by Pyridinium Oximes.
Chemico-Biological Interactions. 2008, 175(1-3), 365-367.
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Musilek K.,
Jampilek J., Dohnal J., Jun D., Gunn-Moore F., Dolezal M., Kuca K.: RP-HPLC
lipophilicity determination of bispyridinium reactivators of
acetylcholinesterase bearing a but-2-ene connecting linker. Analytical &
Bioanalytical Chemistry. 2008, 391(1), 367-372.
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Hamulakova S.,
Kristian P., Jun D., Kuca K., Imrich J., Danihel I., Bohm S., Klika KD.
Synthesis, structure, and cholinergic efect of novel neuroprotective compounds
bearing the tacrine pharmacophore. Heterocycles. 2008, 76(2), 1219-1235.
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Csermely T.,
Kalasz H., Petroianu G., Kuca K., Darvas F., Ludanyi K., Mudhafar AA., Tekes
K.: Analysis of Pyridinium Aldoximes – A Chromatographic Approach. Current
Medicinal Chemistry. 2008, 15(23), 2401-2418.
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Wu Q., Jezkova
A., Yuan Z., Pavlikova L., Dohnal V., Kuca K. Biological degradation of
aflatoxins. Drug Metabolisms Reviews 2009; 41, 1-7.
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Jeong HC.,
Park NJ., Chae CH., Musilek K., Kassa J., Kuca K., Jung YS. Fluorinated
pyridinium oximes as potential reactivators for acetylcholinesterases inhibited
by paraoxon organophosphorus agent. Bioorganic &Medicinal Chemistry.
2009, 17, 6213-7.
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Musilek K.,
Kucera J., Jun D., Dohnal V., Opletalova V., Kuca K.: Monoquaternary pyridinium
salts with modified side chain– synthesis and evaluation on model of tabun- and
paraoxon-inhibited acetylcholinesterase. Bioorganic & Medicinal Chemistry
2008, 16(17), 8218-8223.
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Bajgar J.,
Fusek J., Kassa J., Kuca K., Jun D.: Chemical Aspects of Pharmacological
Prophylaxis Against Nerve Agent Poisoning. Current Medicinal Chemistry. 2009,
16(23), 2977-2986.
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Musilek K.,
Holas O., Misik J., Pohanka M., Novotny L., Dohnal V., Opletalova V., Kuca K. Monooxime-monocarbamoyl
Bispyridinium Xylene-Linked Reactivators of Acetylcholinesterase-Synthesis, In
vitro and Toxicity Evaluation, and Docking Studies. ChemMedChem. 2010,
5(2), 247-54.