TITLE:
Seroprevalence of HBV and HCV among People Living with HIV in Burkina Faso and Diagnostic Performance of HIV/HCV/HBsAg Combined Rapid Test in Comparison with Architect Assays
AUTHORS:
Serge Theophile Soubeiga, Albert Theophane Yonli, Alain Megabtche Nantchouang, Jacques Simpore
KEYWORDS:
HIV, HBV, HCV, Prevalence, Diagnosis, Burkina Faso
JOURNAL NAME:
Open Journal of Medical Microbiology,
Vol.14 No.1,
March
28,
2024
ABSTRACT: Background: The diagnosis of
human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C
virus (HCV) remains a constraint for some populations in sub-Saharan Africa.
This study aimed to determine the prevalence of HBV and HCV in people living
with HIV and to evaluate the performance of a combined rapid test for the
simultaneous detection of HIV, HBV, and HCV. Methods: This is a
cross-sectional study that took place from February 2017 to November 2018 and
included 139 HIV-infected individuals followed up at different medical centers in Ouagadougou, Burkina Faso. HBV and HCV
serology tests were performed on-site using finger prick whole blood with
HIV/HCV/HBsAg combined rapid test and then serum with two reference tests
“Architect HBsAg Qualitative” and “Architect HIV Ag/Ab Combo”. Results:
The mean age of the participants was 57 ± 8 years. Of the 139 participants, 10%
(14/139) were HIV-1 positive, 71.9% (100/139) were HIV-2 positive, and 18.0%
(25/139) were HIV-1/HIV-2 coinfected. The sensitivity and specificity of the
HIV/HCV/HBsAg combined rapid test were 33.33% vs 99.11% and 20% vs 99.25%
compared to Architect HBsAg Qualitative and Architect HIV Ag/Ab Combo,
respectively. The Kappa and Youden Index values were 0.4262 and 0.3244 and
0.2707 and 0.1925, respectively, compared to each of the two reference tests. Conclusion:
The results show that the HIV/HCV/HBsAg combined rapid test has poor diagnostic
efficiency and should not be recommended for the diagnosis of these viruses.